Aptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancer

Detalhes bibliográficos
Autor(a) principal: Almeida, Carlos E. B. de
Data de Publicação: 2017
Outros Autores: Alves, Lais Nascimento, Rocha, Henrique F., Cabral Neto, Januário Bispo, Missailidis, Sotiris
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32010
Resumo: Instituto de Radioproteção e Dosimetria. Comissão Nacional de Energia Nuclear. Laboratório de Radiobiologia. Divisão de Física Médica. Rio de Janeiro, RJ, Brasil.
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spelling Almeida, Carlos E. B. deAlves, Lais NascimentoRocha, Henrique F.Cabral Neto, Januário BispoMissailidis, Sotiris2019-03-08T19:35:17Z2019-03-08T19:35:17Z2017ALMEIDA, Carlos E. B. de et al. Aptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancer. International Journal Of Pharmaceutics, Amsterdam, v. 525, n. 2, p.334-342, 2017.1873-3476https://www.arca.fiocruz.br/handle/icict/3201010.1016/j.ijpharm.2017.03.086engAptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto de Radioproteção e Dosimetria. Comissão Nacional de Energia Nuclear. Laboratório de Radiobiologia. Divisão de Física Médica. Rio de Janeiro, RJ, Brasil.Instituto de Radioproteção e Dosimetria. Comissão Nacional de Energia Nuclear. Laboratório de Radiobiologia. Divisão de Física Médica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Instituto de Radioproteção e Dosimetria. Comissão Nacional de Energia Nuclear. Laboratório de Radiobiologia. Divisão de Física Médica. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Aptamers are oligonucleotide reagents with high affinity and specificity, which among other therapeutic and diagnostic applications have the capability of acting as delivery agents. Thus, aptamers are capable of carrying small molecules, nanoparticles, radiopharmaceuticals or fluorescent agents as well as nucleic acid therapeutics specifically to their target cells. In most cases, the molecules may possess interesting therapeutic properties, but their lack of specificity for a particular cell type, or ability to internalise in such a cell, hinders their clinical development, or cause unwanted side effects. Thus, chemotherapy or radiotherapy agents, famous for their side effects, can be coupled to aptamers for specific delivery. Equally, siRNA have great therapeutic potential and specificity, but one of their shortcomings remain the delivery and internalisation into cells. Various methodologies have been proposed to date, including aptamers, to resolve this problem. Therapeutic or imaging reagents benefit from the adaptability and ease of chemical manipulation of aptamers, their high affinity for the specific marker of a cell type, and their internalisation ability via cell mediated endocytosis. In this review paper, we explore the potential of the aptamers as delivery agents and offer an update on current status and latest advancements.AptamersCancerChemotherapysiRNARadiopharmaceuticsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/32010/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALF09-1-s2.0-S0378517317302740-main.pdfapplication/pdf1028133https://www.arca.fiocruz.br/bitstream/icict/32010/2/F09-1-s2.0-S0378517317302740-main.pdf737e8f1013224eadc51e5db7dd6ce9bbMD52TEXTF09-1-s2.0-S0378517317302740-main.pdf.txtF09-1-s2.0-S0378517317302740-main.pdf.txtExtracted texttext/plain62489https://www.arca.fiocruz.br/bitstream/icict/32010/3/F09-1-s2.0-S0378517317302740-main.pdf.txt9c4f19d6caf30388e9bbdef73c6cd4d7MD53icict/320102019-04-04 02:05:10.034oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-04-04T05:05:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Aptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancer
title Aptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancer
spellingShingle Aptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancer
Almeida, Carlos E. B. de
Aptamers
Cancer
Chemotherapy
siRNA
Radiopharmaceutics
title_short Aptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancer
title_full Aptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancer
title_fullStr Aptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancer
title_full_unstemmed Aptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancer
title_sort Aptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancer
author Almeida, Carlos E. B. de
author_facet Almeida, Carlos E. B. de
Alves, Lais Nascimento
Rocha, Henrique F.
Cabral Neto, Januário Bispo
Missailidis, Sotiris
author_role author
author2 Alves, Lais Nascimento
Rocha, Henrique F.
Cabral Neto, Januário Bispo
Missailidis, Sotiris
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Carlos E. B. de
Alves, Lais Nascimento
Rocha, Henrique F.
Cabral Neto, Januário Bispo
Missailidis, Sotiris
dc.subject.en.pt_BR.fl_str_mv Aptamers
Cancer
Chemotherapy
siRNA
Radiopharmaceutics
topic Aptamers
Cancer
Chemotherapy
siRNA
Radiopharmaceutics
description Instituto de Radioproteção e Dosimetria. Comissão Nacional de Energia Nuclear. Laboratório de Radiobiologia. Divisão de Física Médica. Rio de Janeiro, RJ, Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-03-08T19:35:17Z
dc.date.available.fl_str_mv 2019-03-08T19:35:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA, Carlos E. B. de et al. Aptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancer. International Journal Of Pharmaceutics, Amsterdam, v. 525, n. 2, p.334-342, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32010
dc.identifier.issn.pt_BR.fl_str_mv 1873-3476
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijpharm.2017.03.086
identifier_str_mv ALMEIDA, Carlos E. B. de et al. Aptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancer. International Journal Of Pharmaceutics, Amsterdam, v. 525, n. 2, p.334-342, 2017.
1873-3476
10.1016/j.ijpharm.2017.03.086
url https://www.arca.fiocruz.br/handle/icict/32010
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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