Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil

Detalhes bibliográficos
Autor(a) principal: Mello, Francisco C. A.
Data de Publicação: 2013
Outros Autores: Araujo, Oscar C., Lago, Barbara V., Castro, Ana Rita C. Motta, Moraes, Marcia Terezinha B., Gomes, Selma A., Bello, Gonzalo, Araujo, Natalia M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11474
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Mello, Francisco C. A.Araujo, Oscar C.Lago, Barbara V.Castro, Ana Rita C. MottaMoraes, Marcia Terezinha B.Gomes, Selma A.Bello, GonzaloAraujo, Natalia M.2015-08-19T13:49:17Z2015-08-19T13:49:17Z2013MELLO, Francisco C. A.; et al. Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil. Virology Journal, v.10:236, 8p, 2013.1743-422Xhttps://www.arca.fiocruz.br/handle/icict/1147410.1186/1743-422X-10-236engBioMed CentralBrasilHepatitis B VirusGenotype FBayesian frameworkPhylogeographyBrazilFilogeografiaTeorema de BayesVírus da Hepatite BGenótipoPhylogeography and evolutionary history of hepatitis B virus genotype F in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal de Mato Grosso do Sul. Departamento de Bioquímica e Farmácia. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Background: Hepatitis B virus (HBV) genotype F (HBV/F) is considered to be indigenous to the Americas, but its emergence and spread in the continent remain unknown. Previously, only two HBV/F complete genome sequences from Brazil were available, limiting the contribution of Brazilian isolates to the phylogenetic studies of HBV/F. The present study was carried out to assess the proportion and geographic distributions of HBV/F subgenotypes in Brazil, to determine the full-length genomic sequences of HBV/F isolates from different Brazilian geographic regions, and to investigate the detailed evolutionary history and phylogeography of HBV/F in Brazil. Methods: Complete HBV/F genomes isolated from 12 Brazilian patients, representing the HBV/F subgenotypes circulating in Brazil, were sequenced and analyzed together with sequences retrieved from GenBank, using the Bayesian coalescent and phylogeographic framework. Results: Phylogenetic analysis using all Brazilian HBV/F S-gene sequences available in GenBank showed that HBV/F2a is found at higher frequencies countrywide and corresponds to all sequences isolated in the Brazilian Amazon Basin. In addition, the evolutionary analysis using complete genome sequences estimated an older median ancestral age for the Brazilian HBV/F2a compared to the Brazilian HBV/F1b and HBV/F4 subgenotypes, suggesting that HBV/F2a represents the original native HBV of Brazil. The phylogeographic patterns suggested a north-to-south flow of HBV/F2a from Venezuela to Brazil, whereas HBV/F1b and HBV/F4 strains appeared to have spread from Argentina to Brazil. Conclusions: This study suggests a plausible route of introduction of HBV/F subgenotypes in Brazil and demonstrates the usefulness of recently developed computational tools for investigating the evolutionary history of HBV.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11474/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALfrancisco_mello_etal_IOC_2013.pdfapplication/pdf903354https://www.arca.fiocruz.br/bitstream/icict/11474/2/francisco_mello_etal_IOC_2013.pdffc432e0b018705d312baf68efe0d3d05MD52TEXTfrancisco_mello_etal_IOC_2013.pdf.txtfrancisco_mello_etal_IOC_2013.pdf.txtExtracted texttext/plain40384https://www.arca.fiocruz.br/bitstream/icict/11474/3/francisco_mello_etal_IOC_2013.pdf.txt42cd10047902f564b1abb1a3f80fa83dMD53icict/114742022-06-24 13:08:43.96oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:43Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil
title Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil
spellingShingle Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil
Mello, Francisco C. A.
Brasil
Hepatitis B Virus
Genotype F
Bayesian framework
Phylogeography
Brazil
Filogeografia
Teorema de Bayes
Vírus da Hepatite B
Genótipo
title_short Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil
title_full Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil
title_fullStr Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil
title_full_unstemmed Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil
title_sort Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil
author Mello, Francisco C. A.
author_facet Mello, Francisco C. A.
Araujo, Oscar C.
Lago, Barbara V.
Castro, Ana Rita C. Motta
Moraes, Marcia Terezinha B.
Gomes, Selma A.
Bello, Gonzalo
Araujo, Natalia M.
author_role author
author2 Araujo, Oscar C.
Lago, Barbara V.
Castro, Ana Rita C. Motta
Moraes, Marcia Terezinha B.
Gomes, Selma A.
Bello, Gonzalo
Araujo, Natalia M.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mello, Francisco C. A.
Araujo, Oscar C.
Lago, Barbara V.
Castro, Ana Rita C. Motta
Moraes, Marcia Terezinha B.
Gomes, Selma A.
Bello, Gonzalo
Araujo, Natalia M.
dc.subject.other.pt_BR.fl_str_mv Brasil
topic Brasil
Hepatitis B Virus
Genotype F
Bayesian framework
Phylogeography
Brazil
Filogeografia
Teorema de Bayes
Vírus da Hepatite B
Genótipo
dc.subject.en.pt_BR.fl_str_mv Hepatitis B Virus
Genotype F
Bayesian framework
Phylogeography
Brazil
dc.subject.decs.pt_BR.fl_str_mv Filogeografia
Teorema de Bayes
Vírus da Hepatite B
Genótipo
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2015-08-19T13:49:17Z
dc.date.available.fl_str_mv 2015-08-19T13:49:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MELLO, Francisco C. A.; et al. Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil. Virology Journal, v.10:236, 8p, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11474
dc.identifier.issn.pt_BR.fl_str_mv 1743-422X
dc.identifier.doi.pt_BR.fl_str_mv 10.1186/1743-422X-10-236
identifier_str_mv MELLO, Francisco C. A.; et al. Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil. Virology Journal, v.10:236, 8p, 2013.
1743-422X
10.1186/1743-422X-10-236
url https://www.arca.fiocruz.br/handle/icict/11474
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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