Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection

Detalhes bibliográficos
Autor(a) principal: Amaral, Eduardo Pinheiro
Data de Publicação: 2017
Outros Autores: Andrade, Bruno de Bezerril
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/21099
Resumo: National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, USA / University of São Paulo. Institute of Biomedical Sciences. Laboratory of Immunology of Infectious Diseases. Department of Immunology. São Paulo, SP, Brazil
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spelling Amaral, Eduardo PinheiroAndrade, Bruno de Bezerril2017-09-25T17:59:16Z2017-09-25T17:59:16Z2017AMARAL, E. P.; ANDRADE, B. B. Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection. Clinical Medicine Insights: Case Reports, v. 9, p. 1-10, 2017.1178-6450https://www.arca.fiocruz.br/handle/icict/21099engLibertas AcademicaMycobactériasSensoresNF-κappa BHospedeiroMycobacterium tuberculosisMycobacteriaImmune sensorsNF-κB pathwaysHost defenseMycobacterium tuberculosisNuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, USA / University of São Paulo. Institute of Biomedical Sciences. Laboratory of Immunology of Infectious Diseases. Department of Immunology. São Paulo, SP, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, BrazilThe interactions between pathogens and host cells and the way by which the immune response is modulated during this process ultimately dictate the fate of infection. Host phagocytes exposed to Mycobacterium tuberculosis (M. tuberculosis) sense microbial-associated molecular patterns and activate a series of signaling pathways. In this setting, activation of the nuclear factor κB (NF-κB) initiates transcription of several key genes involved in orchestration of antimycobacterial effector functions. This review describes these major pathways that govern the outcome of host phagocytes infected with M. tuberculosis. Furthermore, we highlight evidence of how M. tuberculosis modulates activation of NF-κB pathways to evade the host antimycobacterial defense.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/21099/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAmaral EP Nuclear factor....pdfAmaral EP Nuclear factor....pdfapplication/pdf880587https://www.arca.fiocruz.br/bitstream/icict/21099/2/Amaral%20EP%20Nuclear%20factor....pdfe75d1d5a02d2962d17d27b9e4db51a06MD52TEXTAmaral EP Nuclear factor....pdf.txtAmaral EP Nuclear factor....pdf.txtExtracted texttext/plain67522https://www.arca.fiocruz.br/bitstream/icict/21099/3/Amaral%20EP%20Nuclear%20factor....pdf.txt2ab120769ccda3f251c8019cd36f6befMD53icict/210992023-03-15 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dc.title.pt_BR.fl_str_mv Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection
title Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection
spellingShingle Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection
Amaral, Eduardo Pinheiro
Mycobactérias
Sensores
NF-κappa B
Hospedeiro
Mycobacterium tuberculosis
Mycobacteria
Immune sensors
NF-κB pathways
Host defense
Mycobacterium tuberculosis
title_short Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection
title_full Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection
title_fullStr Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection
title_full_unstemmed Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection
title_sort Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection
author Amaral, Eduardo Pinheiro
author_facet Amaral, Eduardo Pinheiro
Andrade, Bruno de Bezerril
author_role author
author2 Andrade, Bruno de Bezerril
author2_role author
dc.contributor.author.fl_str_mv Amaral, Eduardo Pinheiro
Andrade, Bruno de Bezerril
dc.subject.other.pt_BR.fl_str_mv Mycobactérias
Sensores
NF-κappa B
Hospedeiro
Mycobacterium tuberculosis
topic Mycobactérias
Sensores
NF-κappa B
Hospedeiro
Mycobacterium tuberculosis
Mycobacteria
Immune sensors
NF-κB pathways
Host defense
Mycobacterium tuberculosis
dc.subject.en.pt_BR.fl_str_mv Mycobacteria
Immune sensors
NF-κB pathways
Host defense
Mycobacterium tuberculosis
description National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, USA / University of São Paulo. Institute of Biomedical Sciences. Laboratory of Immunology of Infectious Diseases. Department of Immunology. São Paulo, SP, Brazil
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-09-25T17:59:16Z
dc.date.available.fl_str_mv 2017-09-25T17:59:16Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AMARAL, E. P.; ANDRADE, B. B. Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection. Clinical Medicine Insights: Case Reports, v. 9, p. 1-10, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/21099
dc.identifier.issn.pt_BR.fl_str_mv 1178-6450
identifier_str_mv AMARAL, E. P.; ANDRADE, B. B. Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection. Clinical Medicine Insights: Case Reports, v. 9, p. 1-10, 2017.
1178-6450
url https://www.arca.fiocruz.br/handle/icict/21099
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Libertas Academica
publisher.none.fl_str_mv Libertas Academica
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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