The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants

Kano, Flora Satiko; Silva, Flavia Alessandra de Souza; Torres, Leticia de Menezes; Lima, Barbara Andreza Soares; Sousa, Taís Nóbrega de; Alves, Jéssica Rafaella dos Santos; Rocha, Roberto Sena; Fontes, Cor Jésus Fernandes; Sanchez, Bruno Antonio Marinho; Adams, John H.; Brito, Cristiana Ferreira Alves de; Pires, Douglas Eduardo Valente; Ascher, David Benjamin; Sell, Ana Maria; Carvalho, Luzia Helena de

The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants

Detalhes bibliográficos
Autor(a) principal:	Kano, Flora Satiko
Data de Publicação:	2016
Outros Autores:	Silva, Flavia Alessandra de Souza, Torres, Leticia de Menezes, Lima, Barbara Andreza Soares, Sousa, Taís Nóbrega de, Alves, Jéssica Rafaella dos Santos, Rocha, Roberto Sena, Fontes, Cor Jésus Fernandes, Sanchez, Bruno Antonio Marinho, Adams, John H., Brito, Cristiana Ferreira Alves de, Pires, Douglas Eduardo Valente, Ascher, David Benjamin, Sell, Ana Maria, Carvalho, Luzia Helena de
Tipo de documento:	Artigo
Idioma:	por
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/20569
Resumo:	Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil

Metadados do item

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spelling	Kano, Flora SatikoSilva, Flavia Alessandra de SouzaTorres, Leticia de MenezesLima, Barbara Andreza SoaresSousa, Taís Nóbrega deAlves, Jéssica Rafaella dos SantosRocha, Roberto SenaFontes, Cor Jésus FernandesSanchez, Bruno Antonio MarinhoAdams, John H.Brito, Cristiana Ferreira Alves dePires, Douglas Eduardo ValenteAscher, David BenjaminSell, Ana MariaCarvalho, Luzia Helena de2017-08-09T18:39:53Z2017-08-09T18:39:53Z2016KANO, Flora Satiko et al. The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants. PLoS Negl Trop Dis., V. 10, n.12, e0005177, 2016https://www.arca.fiocruz.br/handle/icict/205691935-272710.1371/journal.pntd.0005177porPublic Library of SciencePlasmodium vivaxmalariaPlasmodium vivaxmalariaThe Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variantsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/ Fundação Oswaldo Cruz. Centro de Pesquisas Leônidas e Maria Deane., Manaus, AM, BrazilUniversidade Federal de Mato Grosso. Faculdade de Medicina. Cuiabá, MS, BrazilUniversidade Federal de Mato Grosso. Instituto de Ciências da Saúde. Sinop, MS, BrazilUniversity of South Florida. College of Public Health. Department of Global Health. Tampa, FL, United States of AmericaFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/University of Cambridge. Department of Biochemistry. Cambridge, United Kingdom/University of Melbourne. Department of Biochemistry. Victoria, AustraliaUniversidade Estadual de Maringá. Programa de Pós-graduação em Biociências e Fisiopatologia. Maringá, PR, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilBackground: The human malaria parasite Plasmodium vivax infects red blood cells through a key pathway that requires interaction between Duffy binding protein II (DBPII) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). A high proportion of P. vivax-exposed individuals fail to develop antibodies that inhibit DBPII-DARC interaction, and genetic factors that modulate this humoral immune response are poorly characterized. Here, we investigate if DBPII responsiveness could be HLA class II-linked. Methodology/Principal Findings: A community-based open cohort study was carried out in an agricultural settlement of the Brazilian Amazon, in which 336 unrelated volunteers were genotyped for HLA class II (DRB1, DQA1 and DQB1 loci), and their DBPII immune responses were monitored over time (baseline, 6 and 12 months) by conventional serology (DBPII IgG ELISA-detected) and functional assays (inhibition of DBPII–erythrocyte binding). The results demonstrated an increased susceptibility of the DRB113:01 carriers to develop and sustain an anti-DBPII IgG response, while individuals with the haplotype DRB114:02-DQA105:03-DQB103:01 were persistent non-responders. HLA class II gene polymorphisms also influenced the functional properties of DBPII antibodies (BIAbs, binding inhibitory antibodies), with three alleles (DRB107:01, DQA102:01 and DQB1*02:02) comprising a single haplotype linked with the presence and persistence of the BIAbs response. Modelling the structural effects of the HLA-DRB1 variants revealed a number of differences in the peptide-binding groove, which is likely to lead to altered antigen binding and presentation profiles, and hence may explain the differences in subject responses. Conclusions/Significance:The current study confirms the heritability of the DBPII antibody response, with genetic variation in HLA class II genes influencing both the development and persistence of IgG antibody responses. Cellular studies to increase knowledge of the binding affinities of DBPII peptides for class II molecules linked with good or poor antibody responses might lead to the development of strategies for controlling the type of helper T cells activated in response to DBPII.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/20569/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALThe Presence, Persistence and Functional Properties.pdfThe Presence, Persistence and Functional Properties.pdfapplication/pdf10624971https://www.arca.fiocruz.br/bitstream/icict/20569/2/The%20Presence%2c%20Persistence%20and%20Functional%20Properties.pdf0ad518140e7c357b7c3c49ed3b9ffa2cMD52TEXTThe Presence, Persistence and Functional Properties.pdf.txtThe Presence, Persistence and Functional Properties.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv	The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants
title	The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants
spellingShingle	The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants Kano, Flora Satiko Plasmodium vivax malaria Plasmodium vivax malaria
title_short	The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants
title_full	The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants
title_fullStr	The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants
title_full_unstemmed	The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants
title_sort	The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants
author	Kano, Flora Satiko
author_facet	Kano, Flora Satiko Silva, Flavia Alessandra de Souza Torres, Leticia de Menezes Lima, Barbara Andreza Soares Sousa, Taís Nóbrega de Alves, Jéssica Rafaella dos Santos Rocha, Roberto Sena Fontes, Cor Jésus Fernandes Sanchez, Bruno Antonio Marinho Adams, John H. Brito, Cristiana Ferreira Alves de Pires, Douglas Eduardo Valente Ascher, David Benjamin Sell, Ana Maria Carvalho, Luzia Helena de
author_role	author
author2	Silva, Flavia Alessandra de Souza Torres, Leticia de Menezes Lima, Barbara Andreza Soares Sousa, Taís Nóbrega de Alves, Jéssica Rafaella dos Santos Rocha, Roberto Sena Fontes, Cor Jésus Fernandes Sanchez, Bruno Antonio Marinho Adams, John H. Brito, Cristiana Ferreira Alves de Pires, Douglas Eduardo Valente Ascher, David Benjamin Sell, Ana Maria Carvalho, Luzia Helena de
author2_role	author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Kano, Flora Satiko Silva, Flavia Alessandra de Souza Torres, Leticia de Menezes Lima, Barbara Andreza Soares Sousa, Taís Nóbrega de Alves, Jéssica Rafaella dos Santos Rocha, Roberto Sena Fontes, Cor Jésus Fernandes Sanchez, Bruno Antonio Marinho Adams, John H. Brito, Cristiana Ferreira Alves de Pires, Douglas Eduardo Valente Ascher, David Benjamin Sell, Ana Maria Carvalho, Luzia Helena de
dc.subject.other.pt_BR.fl_str_mv	Plasmodium vivax malaria
topic	Plasmodium vivax malaria Plasmodium vivax malaria
dc.subject.en.pt_BR.fl_str_mv	Plasmodium vivax malaria
description	Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil
publishDate	2016
dc.date.issued.fl_str_mv	2016
dc.date.accessioned.fl_str_mv	2017-08-09T18:39:53Z
dc.date.available.fl_str_mv	2017-08-09T18:39:53Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	KANO, Flora Satiko et al. The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants. PLoS Negl Trop Dis., V. 10, n.12, e0005177, 2016
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/20569
dc.identifier.eissn.none.fl_str_mv	1935-272710.1371/journal.pntd.0005177
identifier_str_mv	KANO, Flora Satiko et al. The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants. PLoS Negl Trop Dis., V. 10, n.12, e0005177, 2016 1935-272710.1371/journal.pntd.0005177
url	https://www.arca.fiocruz.br/handle/icict/20569
dc.language.iso.fl_str_mv	por
language	por
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/20569/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/20569/2/The%20Presence%2c%20Persistence%20and%20Functional%20Properties.pdf https://www.arca.fiocruz.br/bitstream/icict/20569/3/The%20Presence%2c%20Persistence%20and%20Functional%20Properties.pdf.txt
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The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants

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