Neurovascular Interactions in Malaria
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48260 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. |
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Lima, Maiara N.Freitas, Rodrigo J. R. X.Passos, Beatriz A. B. R.Darze, Ana Maria G.Faria Neto, Hugo C. CastroMaron-Gutierrez, Tatiana2021-07-16T14:52:33Z2021-07-16T14:52:33Z2021LIMA, Maiara N. et al. Neurovascular Interactions in Malaria. Neuroimmunomodulation, 7 p, May 2021.1021-7401https://www.arca.fiocruz.br/handle/icict/4826010.1159/000515557engKarger PublishersMalariaBarreira hematoencefalicaCélulas endoteliaisMicrogliaAstrócitosNeurôniosMalariaBlood-brain barrierEndothelial cellsMicrogliaAstrocytesNeuronsNeurovascular Interactions in Malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.Malaria is caused by Plasmodium infection and remains a se rious public health problem worldwide, despite control ef forts. Malaria can progress to severe forms, affecting multi ple organs, including the brain causing cerebral malaria (CM). CM is the most severe neurological complication of malaria, and cognitive and behavior deficits are commonly reported in surviving patients. The number of deaths from malaria has been reducing in recent years, and as a conse quence, neurological sequelae have been more evident. Neurological damage in malaria might be related to the neu roinflammation, characterized by glia cell activation, neuro nal apoptosis and changes in the blood-brain barrier (BBB) integrity. The neurovascular unit (NVU) is responsible for maintaining the homeostasis of the BBB. Endothelial and pericytes cells in the cerebral microvasculature and neural cells, as astrocytes, neurons, and microglia, compose the NVU. The NVU can be disturbed by parasite metabolic prod ucts, such as heme and hemozoin, or cytokines that can promote activation of endothelial and glial cells and lead to in creased BBB permeability and subsequently neurodegener ation. In this review, we will approach the main changes that happen in the cells of the NVU due to neuroinflammation caused by malaria infection, and elucidate how the systemic pathophysiology is involved in the onset and progression of CM.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48260/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALHugoC_FariaNeto_etal_IOC_2021.pdfHugoC_FariaNeto_etal_IOC_2021.pdfapplication/pdf557455https://www.arca.fiocruz.br/bitstream/icict/48260/2/HugoC_FariaNeto_etal_IOC_2021.pdf99b76a49f62e827e0bb28431bf5c059dMD52TEXTHugoC_FariaNeto_etal_IOC_2021.pdf.txtHugoC_FariaNeto_etal_IOC_2021.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Neurovascular Interactions in Malaria |
| title |
Neurovascular Interactions in Malaria |
| spellingShingle |
Neurovascular Interactions in Malaria Lima, Maiara N. Malaria Barreira hematoencefalica Células endoteliais Microglia Astrócitos Neurônios Malaria Blood-brain barrier Endothelial cells Microglia Astrocytes Neurons |
| title_short |
Neurovascular Interactions in Malaria |
| title_full |
Neurovascular Interactions in Malaria |
| title_fullStr |
Neurovascular Interactions in Malaria |
| title_full_unstemmed |
Neurovascular Interactions in Malaria |
| title_sort |
Neurovascular Interactions in Malaria |
| author |
Lima, Maiara N. |
| author_facet |
Lima, Maiara N. Freitas, Rodrigo J. R. X. Passos, Beatriz A. B. R. Darze, Ana Maria G. Faria Neto, Hugo C. Castro Maron-Gutierrez, Tatiana |
| author_role |
author |
| author2 |
Freitas, Rodrigo J. R. X. Passos, Beatriz A. B. R. Darze, Ana Maria G. Faria Neto, Hugo C. Castro Maron-Gutierrez, Tatiana |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Lima, Maiara N. Freitas, Rodrigo J. R. X. Passos, Beatriz A. B. R. Darze, Ana Maria G. Faria Neto, Hugo C. Castro Maron-Gutierrez, Tatiana |
| dc.subject.other.pt_BR.fl_str_mv |
Malaria Barreira hematoencefalica Células endoteliais Microglia Astrócitos Neurônios |
| topic |
Malaria Barreira hematoencefalica Células endoteliais Microglia Astrócitos Neurônios Malaria Blood-brain barrier Endothelial cells Microglia Astrocytes Neurons |
| dc.subject.en.pt_BR.fl_str_mv |
Malaria Blood-brain barrier Endothelial cells Microglia Astrocytes Neurons |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. |
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2021 |
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2021-07-16T14:52:33Z |
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2021-07-16T14:52:33Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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LIMA, Maiara N. et al. Neurovascular Interactions in Malaria. Neuroimmunomodulation, 7 p, May 2021. |
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https://www.arca.fiocruz.br/handle/icict/48260 |
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1021-7401 |
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10.1159/000515557 |
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LIMA, Maiara N. et al. Neurovascular Interactions in Malaria. Neuroimmunomodulation, 7 p, May 2021. 1021-7401 10.1159/000515557 |
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Karger Publishers |
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Karger Publishers |
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