Effectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40751 |
Resumo: | Comparar la eficacia de los antivirales genéricos de acción directa y los medicamentos de marca para el tratamiento de la infección por el virus de la hepatitis C (VHC) mediante la realización de una revisión sistemática y un metaanálisis. |
| id |
CRUZ_4053bbade9c74fcf2a66947f9fb7f5b9 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/40751 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Perazzo, HugoCastro, RodolfoLuz, Paula MendesBanholi, MarianaGoldenzon, Rafaela VCardoso, Sandra WGrinsztejn, BeatrizSantos, Valdiléa Gonçalves Veloso dos2020-04-14T15:57:04Z2020-04-14T15:57:04Z2020PERAZZO, Hugo et al. Effectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysis. Bulletin of the World Health Organization, v. 98, n. 3, p. 188-197, 2020.0042-9686https://www.arca.fiocruz.br/handle/icict/4075110.2471/BLT.19.231522engWorld Health OrganizationEffectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleComparar la eficacia de los antivirales genéricos de acción directa y los medicamentos de marca para el tratamiento de la infección por el virus de la hepatitis C (VHC) mediante la realización de una revisión sistemática y un metaanálisis.Comparer l’efficacité des antiviraux à action directe génériques et des médicaments de marque pour traiter l'infection par le virus de l’hépatite C (VHC) à l’aide d’une revue systématique et d’une méta-analyse.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Objective: To compare the efficacy of generic direct-acting agents and brand-name medicines for treating hepatitis C virus (HCV) infection by conducting a systematic review and meta-analysis. Methods: We searched online databases for studies that reported sustained virological responses 12 weeks after the end of HCV treatment with generic direct-acting agents. We derived pooled proportions of treated patients with a sustained virological response from intentionto-treat and per-protocol analyses. In addition, we calculated the pooled relative risk (RR) of a sustained virological response brand-name versus generic direct-acting agents using a random-effects model (DerSimonian–Laird) from the data available. Between-study heterogeneity was assessed using the I 2 statistic. Findings: We identified 19 studies involving a total of 57 433 individuals from eight territories or regions. The pooled overall proportions of patients with a sustained virological response were 98% (95% confidence interval, CI: 97–99; 18 studies; I 2=94.1%) in per-protocol analyses and 96% (95% CI: 93–98; 8 studies; I 2=68.1%) in intention-to-treat analyses. The likelihood of a sustained virological response with brandname medicines was similar to that with generic direct-acting agents (RR: 1.00; 95% CI: 0.98–1.02; I 2=0.0%). The likelihood of a sustained virological response was significantly higher in patients without than with cirrhosis (RR:1.03; 95% CI: 1.01–1.06; 7 studies) but was not significantly affected by either previous treatment (3 studies) or human immunodeficiency virus coinfection (3 studies). Conclusion: Generic direct-acting agents are highly effective for treating hepatitis C. Generic agents should be considered in resourceconstrained settings for decreasing the burden of liver disease in HCV-infected patients.Antiviral AgentsHepatitis CTreatment OutcomeDirect-acting agentsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/40751/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALEffectiveness of generic_Hugo_Perazzo_etal_INI_2020.pdfEffectiveness of generic_Hugo_Perazzo_etal_INI_2020.pdfapplication/pdf2913391https://www.arca.fiocruz.br/bitstream/icict/40751/2/Effectiveness%20of%20generic_Hugo_Perazzo_etal_INI_2020.pdf777bc736d358e12eff683d856c0d3fc1MD52TEXTEffectiveness of generic_Hugo_Perazzo_etal_INI_2020.pdf.txtEffectiveness of generic_Hugo_Perazzo_etal_INI_2020.pdf.txtExtracted texttext/plain90830https://www.arca.fiocruz.br/bitstream/icict/40751/3/Effectiveness%20of%20generic_Hugo_Perazzo_etal_INI_2020.pdf.txt6f1281597b50767932cc4a2c04709b40MD53icict/407512023-06-15 16:19:00.347oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-15T19:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Effectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysis |
| title |
Effectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysis |
| spellingShingle |
Effectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysis Perazzo, Hugo Antiviral Agents Hepatitis C Treatment Outcome Direct-acting agents |
| title_short |
Effectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysis |
| title_full |
Effectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysis |
| title_fullStr |
Effectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysis |
| title_full_unstemmed |
Effectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysis |
| title_sort |
Effectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysis |
| author |
Perazzo, Hugo |
| author_facet |
Perazzo, Hugo Castro, Rodolfo Luz, Paula Mendes Banholi, Mariana Goldenzon, Rafaela V Cardoso, Sandra W Grinsztejn, Beatriz Santos, Valdiléa Gonçalves Veloso dos |
| author_role |
author |
| author2 |
Castro, Rodolfo Luz, Paula Mendes Banholi, Mariana Goldenzon, Rafaela V Cardoso, Sandra W Grinsztejn, Beatriz Santos, Valdiléa Gonçalves Veloso dos |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Perazzo, Hugo Castro, Rodolfo Luz, Paula Mendes Banholi, Mariana Goldenzon, Rafaela V Cardoso, Sandra W Grinsztejn, Beatriz Santos, Valdiléa Gonçalves Veloso dos |
| dc.subject.en.pt_BR.fl_str_mv |
Antiviral Agents Hepatitis C Treatment Outcome Direct-acting agents |
| topic |
Antiviral Agents Hepatitis C Treatment Outcome Direct-acting agents |
| description |
Comparar la eficacia de los antivirales genéricos de acción directa y los medicamentos de marca para el tratamiento de la infección por el virus de la hepatitis C (VHC) mediante la realización de una revisión sistemática y un metaanálisis. |
| publishDate |
2020 |
| dc.date.accessioned.fl_str_mv |
2020-04-14T15:57:04Z |
| dc.date.available.fl_str_mv |
2020-04-14T15:57:04Z |
| dc.date.issued.fl_str_mv |
2020 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
PERAZZO, Hugo et al. Effectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysis. Bulletin of the World Health Organization, v. 98, n. 3, p. 188-197, 2020. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/40751 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0042-9686 |
| dc.identifier.doi.none.fl_str_mv |
10.2471/BLT.19.231522 |
| identifier_str_mv |
PERAZZO, Hugo et al. Effectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysis. Bulletin of the World Health Organization, v. 98, n. 3, p. 188-197, 2020. 0042-9686 10.2471/BLT.19.231522 |
| url |
https://www.arca.fiocruz.br/handle/icict/40751 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
World Health Organization |
| publisher.none.fl_str_mv |
World Health Organization |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/40751/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/40751/2/Effectiveness%20of%20generic_Hugo_Perazzo_etal_INI_2020.pdf https://www.arca.fiocruz.br/bitstream/icict/40751/3/Effectiveness%20of%20generic_Hugo_Perazzo_etal_INI_2020.pdf.txt |
| bitstream.checksum.fl_str_mv |
586c046dcfeef936e32f0323bb9a47c0 777bc736d358e12eff683d856c0d3fc1 6f1281597b50767932cc4a2c04709b40 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813008833085177856 |