Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | doi.org/10.1016/j.jddst.2021.102803 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/51205 |
Resumo: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
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Souza, Myla Lôbo deDourado, DouglasLôbo, Ivon PinheiroPires, Vinícius CoutoAraújo, Sara Nunes de OliveiraRebouças, Juliana de SouzaCosta, Ana MariaFernandes, Caio PinhoTavares, Natalia MachadoPereira, Neila de PaulaFormiga, Fabio Rocha2022-02-15T13:59:26Z2022-02-15T13:59:26Z2022Souza, Myla Lôbo de et al. Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells. Journal of Drug Delivery Science and Technology, v. 67, p. 1-12, 2022.1773-2247https://www.arca.fiocruz.br/handle/icict/51205doi.org/10.1016/j.jddst.2021.102803Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Medicamentos e Cosméticos. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Medicamentos e Cosméticos. Salvador, BA, Brasil.Universidade Estadual de Santa Cruz. Grupo de Bioenergia e Meio Ambiente. Ilhéus, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil.Empresa Brasileira de Pesquisa Agropecuária. Rede Passitec, Brasília, DF, Brasil.Universidade Federal do Amapá. Departamento de Ciências Biológicas e da Saúde. Laboratório de Nanobiotecnologia Fitofarmacêutica. Macapá, AP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Medicamentos e Cosméticos. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade de Pernambuco. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada. Recife, PE, Brasil.Despite the potential of Passiflora spp. as potential as source of bioactive compounds, poor aqueous solubility and stability issues restrict their use in pharmaceutical field. The most suitable approach to overcome such limitations is the development of formulations based on proper delivery systems. Among them, nanoemulsions have been widely used as carrier systems that can guarantee better cutaneous performance of herbal oils. This study evaluated physicochemical properties and cellular effects of seed oils from four varieties of wild Passiflora spp. The fatty acids profile of the seed oils was analyzed by gas chromatography and cell viability assay was performed on J774 macrophages. The nanoemulsions were prepared for the different seeds oils and cell proliferation was evaluated on HaCaT keratinocytes. The oils presented a predominance of unsaturated fatty acids, mainly linoleic acid (>65%) and no cytotoxic effects were observed on J774 cells up to 100 μg/mL. All nanoemulsions presented droplet size about 200 nm, narrow polydispersity index (<0.300) and overall, physicochemical properties consistent with good stability after 90 days of storage. The oils and nanoemulsions induced proliferation of keratinocytes, where nanoemulsions prepared with P. alata oil was the most effective, reaching 150% effect. These findings demonstrate proper cytocompatibility of oils from wild Passiflora spp. and their ability to stimulate the proliferation of keratinocytes, which suggest their potential use as herbal bioactives for dermal healing. Their incorporation in nanoemulsions is an innovative approach for obtaining nanotechnological dermatological products through a sustainable concept that can reach organoleptic characteristics superior to the in natura product.engElsevierPassifloraProliferação de célulasPassifloraCell proliferationPassifloraProliferación CelularPassifloraProlifération cellulaireWild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51205/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSouza, M. L de - Wild Passiflora....pdfSouza, M. L de - Wild Passiflora....pdfapplication/pdf7949104https://www.arca.fiocruz.br/bitstream/icict/51205/2/Souza%2c%20M.%20L%20de%20-%20Wild%20Passiflora....pdf7a5b92de68a8581ad36238b7ae941170MD52icict/512052023-03-15 14:34:35.107oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:35Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells |
| title |
Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells |
| spellingShingle |
Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells Souza, Myla Lôbo de Passiflora Proliferação de células Passiflora Cell proliferation Passiflora Proliferación Celular Passiflora Prolifération cellulaire |
| title_short |
Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells |
| title_full |
Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells |
| title_fullStr |
Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells |
| title_full_unstemmed |
Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells |
| title_sort |
Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells |
| author |
Souza, Myla Lôbo de |
| author_facet |
Souza, Myla Lôbo de Dourado, Douglas Lôbo, Ivon Pinheiro Pires, Vinícius Couto Araújo, Sara Nunes de Oliveira Rebouças, Juliana de Souza Costa, Ana Maria Fernandes, Caio Pinho Tavares, Natalia Machado Pereira, Neila de Paula Formiga, Fabio Rocha |
| author_role |
author |
| author2 |
Dourado, Douglas Lôbo, Ivon Pinheiro Pires, Vinícius Couto Araújo, Sara Nunes de Oliveira Rebouças, Juliana de Souza Costa, Ana Maria Fernandes, Caio Pinho Tavares, Natalia Machado Pereira, Neila de Paula Formiga, Fabio Rocha |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Myla Lôbo de Dourado, Douglas Lôbo, Ivon Pinheiro Pires, Vinícius Couto Araújo, Sara Nunes de Oliveira Rebouças, Juliana de Souza Costa, Ana Maria Fernandes, Caio Pinho Tavares, Natalia Machado Pereira, Neila de Paula Formiga, Fabio Rocha |
| dc.subject.other.pt_BR.fl_str_mv |
Passiflora Proliferação de células |
| topic |
Passiflora Proliferação de células Passiflora Cell proliferation Passiflora Proliferación Celular Passiflora Prolifération cellulaire |
| dc.subject.en.pt_BR.fl_str_mv |
Passiflora Cell proliferation |
| dc.subject.es.pt_BR.fl_str_mv |
Passiflora Proliferación Celular |
| dc.subject.fr.pt_BR.fl_str_mv |
Passiflora Prolifération cellulaire |
| description |
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
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2022 |
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2022-02-15T13:59:26Z |
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2022-02-15T13:59:26Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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Souza, Myla Lôbo de et al. Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells. Journal of Drug Delivery Science and Technology, v. 67, p. 1-12, 2022. |
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https://www.arca.fiocruz.br/handle/icict/51205 |
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1773-2247 |
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doi.org/10.1016/j.jddst.2021.102803 |
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Souza, Myla Lôbo de et al. Wild Passiflora (Passiflora spp.) seed oils and their nanoemulsions induce proliferation in HaCaT keratinocytes cells. Journal of Drug Delivery Science and Technology, v. 67, p. 1-12, 2022. 1773-2247 doi.org/10.1016/j.jddst.2021.102803 |
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Elsevier |
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Elsevier |
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