Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25418 |
Resumo: | CNPq (produtividade em pesquisa) and FAPERJ (Cientistas do Nosso Estado). LG-S received scientific initiation fellowship from Fundacão de Amparo à Pesquisa da Bahia (FAPESB) and Fundacão Oswaldo Cruz (FIOCRUZ). |
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Miranda, PryscilaSantana, Leonardo GilOliveira, Marina G.Mesquita, Eliene Denites DuarteSilva, Elisangela Costa daRauwerdink, AnneloekCobelens, FrankOliveira, Martha Maria deAndrade, Bruno de BezerrilKritski, Afrânio Lineu2018-03-20T13:53:35Z2018-03-20T13:53:35Z2017MIRANDA, P. et al. Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation. Plos One, v. 12, n. 4, p. 1-12, 2017.1932-6203https://www.arca.fiocruz.br/handle/icict/2541810.1371/journal.pone.0175278CNPq (produtividade em pesquisa) and FAPERJ (Cientistas do Nosso Estado). LG-S received scientific initiation fellowship from Fundacão de Amparo à Pesquisa da Bahia (FAPESB) and Fundacão Oswaldo Cruz (FIOCRUZ).Federal University of Rio de Janeiro. Medical School. Tuberculosis Academic Program. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação Jose Silveira. Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brazil.Federal University of Rio de Janeiro. Medical School. Tuberculosis Academic Program. Rio de Janeiro, RJ, Brazil.Ary Parreira Institute. State Secretary of Health of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.State University of North Fluminense Darcy Ribeiro. Recognize the Biology Laboratory, Center of Bioscience and Biotechnology. Rio de Janeiro, RJ, Brazil / Rede Brasileira de Pesquisas em Tuberculose. Rio de Janeiro, RJ, Brazil.Amsterdam Institute for Global Health and Development. Academic Medical Centre. Amsterdam, The Netherlands.Amsterdam Institute for Global Health and Development. Academic Medical Centre. Amsterdam, The Netherlands.Rede Brasileira de Pesquisas em Tuberculose. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação Jose Silveira. Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Rede Brasileira de Pesquisas em Tuberculose. Rio de Janeiro, RJ, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Salvador. Laureate International Universities. Salvador, BA, Brazil.Federal University of Rio de Janeiro. Medical School. Tuberculosis Academic Program. Rio de Janeiro, RJ, Brazil / Rede Brasileira de Pesquisas em Tuberculose. Rio de Janeiro, RJ, Brazil.Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis infection and the lack of early biomarkers that predict treatment outcomes. Host Inflammation markers have been associated with tuberculosis (TB) pathogenesis. In the present study, we tested if circulating levels of C-reactive protein (CRP) and ferritin reflect mycobacterial loads and inflammation in pulmonary TB (PTB) patients undergoing anti-tuberculous therapy (ATT). Methods Prospective measurements of CRP and ferritin, used as readouts of systemic inflammation, were performed in cryopreserved serum samples from 165 Brazilian patients with active PTB initiating ATT. Associations between levels of these laboratory parameters with mycobacterial loads in sputum as well as with sputum conversion at day 60 of ATT were tested. Results: Circulating levels of both ferritin and CRP gradually decreased over time on ATT. At pretreatment, concentrations of these parameters were unable to distinguish patients with positive from those with negative acid-fast bacilli (AFB) in sputum cultures. However, patients who remained with positive cultures at day 60 of ATT exhibited heightened levels of these inflammatory markers compared to those with negative cultures at that time point. Conclusions: CRP and Ferritin levels in serum may be useful to identify patients with positive cultures at day 60 of ATT.engPublic Library of ScienceTuberculose PulmonarProteína C-reativaFerritinasHumanosAgentes antituberculososTuberculosis PulmonaryC-Reactive ProteinFerritinsHumansAntitubercular AgentsSustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25418/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMiranda P Sustained elevated levels of C-reactive protein....pdfMiranda P Sustained elevated levels of C-reactive 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| dc.title.pt_BR.fl_str_mv |
Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation |
| title |
Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation |
| spellingShingle |
Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation Miranda, Pryscila Tuberculose Pulmonar Proteína C-reativa Ferritinas Humanos Agentes antituberculosos Tuberculosis Pulmonary C-Reactive Protein Ferritins Humans Antitubercular Agents |
| title_short |
Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation |
| title_full |
Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation |
| title_fullStr |
Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation |
| title_full_unstemmed |
Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation |
| title_sort |
Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation |
| author |
Miranda, Pryscila |
| author_facet |
Miranda, Pryscila Santana, Leonardo Gil Oliveira, Marina G. Mesquita, Eliene Denites Duarte Silva, Elisangela Costa da Rauwerdink, Anneloek Cobelens, Frank Oliveira, Martha Maria de Andrade, Bruno de Bezerril Kritski, Afrânio Lineu |
| author_role |
author |
| author2 |
Santana, Leonardo Gil Oliveira, Marina G. Mesquita, Eliene Denites Duarte Silva, Elisangela Costa da Rauwerdink, Anneloek Cobelens, Frank Oliveira, Martha Maria de Andrade, Bruno de Bezerril Kritski, Afrânio Lineu |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Miranda, Pryscila Santana, Leonardo Gil Oliveira, Marina G. Mesquita, Eliene Denites Duarte Silva, Elisangela Costa da Rauwerdink, Anneloek Cobelens, Frank Oliveira, Martha Maria de Andrade, Bruno de Bezerril Kritski, Afrânio Lineu |
| dc.subject.other.pt_BR.fl_str_mv |
Tuberculose Pulmonar Proteína C-reativa Ferritinas Humanos Agentes antituberculosos |
| topic |
Tuberculose Pulmonar Proteína C-reativa Ferritinas Humanos Agentes antituberculosos Tuberculosis Pulmonary C-Reactive Protein Ferritins Humans Antitubercular Agents |
| dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis Pulmonary C-Reactive Protein Ferritins Humans Antitubercular Agents |
| description |
CNPq (produtividade em pesquisa) and FAPERJ (Cientistas do Nosso Estado). LG-S received scientific initiation fellowship from Fundacão de Amparo à Pesquisa da Bahia (FAPESB) and Fundacão Oswaldo Cruz (FIOCRUZ). |
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2017 |
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2017 |
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2018-03-20T13:53:35Z |
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2018-03-20T13:53:35Z |
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MIRANDA, P. et al. Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation. Plos One, v. 12, n. 4, p. 1-12, 2017. |
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https://www.arca.fiocruz.br/handle/icict/25418 |
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1932-6203 |
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10.1371/journal.pone.0175278 |
| identifier_str_mv |
MIRANDA, P. et al. Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation. Plos One, v. 12, n. 4, p. 1-12, 2017. 1932-6203 10.1371/journal.pone.0175278 |
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