Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies

Detalhes bibliográficos
Autor(a) principal: Suan-Sin, Foo
Data de Publicação: 2018
Outros Autores: Weiqiang, Chen, Yen, Chan, Wai-Suet, Lee, Shin-Ae, Lee, Genhong, Cheng, Nielsen-Saines, Karin, Brasil, Patrícia, Jung, Jae U.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31038
Resumo: University of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA.
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spelling Suan-Sin, FooWeiqiang, ChenYen, ChanWai-Suet, LeeShin-Ae, LeeGenhong, ChengNielsen-Saines, KarinBrasil, PatríciaJung, Jae U.2019-01-15T13:50:47Z2019-01-15T13:50:47Z2018SUAN-SIN, Foo et al. Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies. JCI Insight, v. 3, n. 21, p. 1-11, 2018.2379-3708https://www.arca.fiocruz.br/handle/icict/3103810.1172/jci.insight.124152engBiomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnanciesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA.University of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA.University of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Obstetrics and Gynecology. Division of Maternal-Fetal Medicine. Los Angeles, CA, USA.University of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA / Griffith University, Gold Coast. Institute for Glycomics. Southport, Queensland, Australia.University of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA.University of California, Los Angeles. David Geffen School of Medicine. Department of Microbiology and Molecular Genetics. Los Angeles, CA, USA.University of California, Los Angeles. David Geffen School of Medicine. Marion Davies Children’s Health Center. Division of Pediatric Infectious Diseases. Los Angeles, CA, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.University of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA.BACKGROUND. An intricate fetal-maternal immune crosstalk during pregnancy is essential for a healthy birth. Hence, the infection-induced alterations of maternal immunity often lead to adverse outcomes for mother and/or child. The emergence of Zika virus (ZIKV) infection in pregnant women has been associated with more than 3,000 cases of microcephaly and nervous system malformations. METHODS. To explore the potential correlation of ZIKV-induced alteration of maternal immunity with fetal abnormalities, we performed extensive sera immunoprofiling of 74 pregnant women: 30 symptomatic ZIKV+ pregnant patients and 30 healthy pregnant controls in ZIKV-endemic Rio de Janeiro, along with 14 healthy pregnant controls in non-endemic Los Angeles. RESULTS. Extensive multiplexing analysis of 69 cytokines revealed that CXCL10, CCL2, and CCL8 chemokines were specifically associated with symptomatic ZIKV+ infection during pregnancy, and distinct immunoprofiles were detected at different trimesters in ZIKV-infected pregnant women. Intriguingly, the high CCL2 level and its inverse correlation with CD163, TNFRSF1A, and CCL22 levels was apparently associated with ZIKV-induced abnormal birth. CONCLUSION. Our findings provide insights into the alteration of ZIKV-elicited maternal immunity, serving as a potential clinical biomarker platform.BiomarkersImmunoprofilesFetal abnormalitiesZIKV-positive pregnanciesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/31038/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Suan_Sin_Foo_etal_INI_2018.pdfve_Suan_Sin_Foo_etal_INI_2018.pdfapplication/pdf3900252https://www.arca.fiocruz.br/bitstream/icict/31038/2/ve_Suan_Sin_Foo_etal_INI_2018.pdf2b4eabf9e64fde6cb7e6ef76bc0edeb8MD52TEXTve_Suan_Sin_Foo_etal_INI_2018.pdf.txtve_Suan_Sin_Foo_etal_INI_2018.pdf.txtExtracted texttext/plain39850https://www.arca.fiocruz.br/bitstream/icict/31038/3/ve_Suan_Sin_Foo_etal_INI_2018.pdf.txt2c758ea69ecf340c010edf7fd0c8f17eMD53icict/310382019-01-16 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dc.title.pt_BR.fl_str_mv Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies
title Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies
spellingShingle Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies
Suan-Sin, Foo
Biomarkers
Immunoprofiles
Fetal abnormalities
ZIKV-positive pregnancies
title_short Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies
title_full Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies
title_fullStr Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies
title_full_unstemmed Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies
title_sort Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies
author Suan-Sin, Foo
author_facet Suan-Sin, Foo
Weiqiang, Chen
Yen, Chan
Wai-Suet, Lee
Shin-Ae, Lee
Genhong, Cheng
Nielsen-Saines, Karin
Brasil, Patrícia
Jung, Jae U.
author_role author
author2 Weiqiang, Chen
Yen, Chan
Wai-Suet, Lee
Shin-Ae, Lee
Genhong, Cheng
Nielsen-Saines, Karin
Brasil, Patrícia
Jung, Jae U.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Suan-Sin, Foo
Weiqiang, Chen
Yen, Chan
Wai-Suet, Lee
Shin-Ae, Lee
Genhong, Cheng
Nielsen-Saines, Karin
Brasil, Patrícia
Jung, Jae U.
dc.subject.en.pt_BR.fl_str_mv Biomarkers
Immunoprofiles
Fetal abnormalities
ZIKV-positive pregnancies
topic Biomarkers
Immunoprofiles
Fetal abnormalities
ZIKV-positive pregnancies
description University of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-01-15T13:50:47Z
dc.date.available.fl_str_mv 2019-01-15T13:50:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SUAN-SIN, Foo et al. Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies. JCI Insight, v. 3, n. 21, p. 1-11, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31038
dc.identifier.issn.pt_BR.fl_str_mv 2379-3708
dc.identifier.doi.none.fl_str_mv 10.1172/jci.insight.124152
identifier_str_mv SUAN-SIN, Foo et al. Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies. JCI Insight, v. 3, n. 21, p. 1-11, 2018.
2379-3708
10.1172/jci.insight.124152
url https://www.arca.fiocruz.br/handle/icict/31038
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/31038/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/31038/2/ve_Suan_Sin_Foo_etal_INI_2018.pdf
https://www.arca.fiocruz.br/bitstream/icict/31038/3/ve_Suan_Sin_Foo_etal_INI_2018.pdf.txt
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