In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25544 |
Resumo: | LTF / UFPB, ao LIKA / UFPE e à FIOCRUZ-PE pelo apoio aos experimentos e à CAPES por uma bolsa de estudos. |
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Matos-Rocha, Thiago JoséCavalcanti, Marília Gabriela dos SantosBarbosa-Filho, José MariaLúcio, Ana Silvia Suassuna CarneiroVeras, Dyana LealFeitosa, Ana Paula SampaioSiqueira Júnior, José Pinto deAlmeida, Reinaldo Nóbrega deMarques, Márcia Ortiz MayoAlves, Luiz CarlosBrayner, Fábio André2018-03-28T14:32:39Z2018-03-28T14:32:39Z2013MATOS-ROCHA, T. J. et al. In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni. Planta Medica, v. 79, n. 14, p. 1307–1312, set. 2013.1439-0221https://www.arca.fiocruz.br/handle/icict/2554410.1055/s-0033-1350732LTF / UFPB, ao LIKA / UFPE e à FIOCRUZ-PE pelo apoio aos experimentos e à CAPES por uma bolsa de estudos.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Laboratório de Biologia Celular e Molecular. Recife, PE, Brasil / Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Laboratório de Biologia Celular e Molecular. Recife, PE, Brasil / Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.Universidade Federal da Paraíba. João Pessoa, PB, Brasil.Universidade Federal da Paraíba. João Pessoa, PB, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Laboratório de Biologia Celular e Molecular. Recife, PE, Brasil / Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Laboratório de Biologia Celular e Molecular. Recife, PE, Brasil / Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.Universidade Federal da Paraíba. João Pessoa, PB, Brasil.Universidade Federal da Paraíba. João Pessoa, PB, Brasil.Instituto Agronômico de Campinas. Centro de Pesquisa e Desenvolvimento de Recursos Genéticos Vegetais e Fitoquímicos. Laboratório de Produtos Naturais. Campinas, São Paulo, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Laboratório de Biologia Celular e Molecular. Recife, PE, Brasil / Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Laboratório de Biologia Celular e Molecular. Recife, PE, Brasil / Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil.This study aimed to determine the composition of the essential oil of Mentha x villosa and to evaluate its biological effects in vitro on adult worms of S. mansoni. Rotundifolone (70.96 %), limonene (8.75 %), trans-caryophyllene (1.46 %), and β-pinene (0.81 %) were shown to be the major constituents of this oil. Adult worms of S. mansoni were incubated with different concentrations of the essential oil (1, 10, 100, 250, 500, and 1000 µg/mL) and of its constituents rotundifolone (0.7, 3.54, 7.09, 70.96, 177.4, 354.8, and 700.96 µg/mL), limonene (43.75 µg/mL), trans-caryophyllene (7.3 µg/mL), and β-pinene (4.03 µg/mL). No schistosomicidal activity was identified at the trans-caryophyllene and β-pinene concentrations studied. However, use of the essential oil (10 µg/mL), rotundifolone (7.09 µg/mL), and limonene (43.75 µg/mL) resulted in decreased worm motility continuing until 96 hours of observation. At higher concentrations (100 and 70.96 µg/mL, respectively), both the essential oil and rotundifolone caused mortality among adult worms of S. mansoni. The positive control praziquantel caused the death of all parasites after 24 h of evaluation. The results from this study suggest that the essential oil of Mentha x villosa presents schistosomicidal efficacy.engLamiaceaeMentha x villosaSchistosoma mansoniAtividade esquistossomicidaProdutos naturaisLamiaceaeMentha x villosaSchistosoma mansoniSchistosomicidal activityNatural productsAnimaisCompostos bicíclicos em ponte / análiseCompostos bicíclicos em ponte / farmacologiaCiclohexenos / análiseCiclohexenos / farmacologiaMentha / químicaMonoterpenos / análiseMonoterpenos / farmacologiaÓleos voláteis / químicaÓleos Voláteis / FarmacêuticosExtratos Vegetais / químicaExtratos Vegetais / FarmacologiaSchistosoma mansoni / efeitos de drogasEsquistossomicidas / farmacologiaSesquiterpenos / análiseSesquiterpenos / farmacologiaTerpenos / análiseTerpenos / farmacologiaIn vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma 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dc.title.pt_BR.fl_str_mv |
In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni |
title |
In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni |
spellingShingle |
In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni Matos-Rocha, Thiago José Lamiaceae Mentha x villosa Schistosoma mansoni Atividade esquistossomicida Produtos naturais Lamiaceae Mentha x villosa Schistosoma mansoni Schistosomicidal activity Natural products Animais Compostos bicíclicos em ponte / análise Compostos bicíclicos em ponte / farmacologia Ciclohexenos / análise Ciclohexenos / farmacologia Mentha / química Monoterpenos / análise Monoterpenos / farmacologia Óleos voláteis / química Óleos Voláteis / Farmacêuticos Extratos Vegetais / química Extratos Vegetais / Farmacologia Schistosoma mansoni / efeitos de drogas Esquistossomicidas / farmacologia Sesquiterpenos / análise Sesquiterpenos / farmacologia Terpenos / análise Terpenos / farmacologia |
title_short |
In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni |
title_full |
In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni |
title_fullStr |
In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni |
title_full_unstemmed |
In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni |
title_sort |
In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni |
author |
Matos-Rocha, Thiago José |
author_facet |
Matos-Rocha, Thiago José Cavalcanti, Marília Gabriela dos Santos Barbosa-Filho, José Maria Lúcio, Ana Silvia Suassuna Carneiro Veras, Dyana Leal Feitosa, Ana Paula Sampaio Siqueira Júnior, José Pinto de Almeida, Reinaldo Nóbrega de Marques, Márcia Ortiz Mayo Alves, Luiz Carlos Brayner, Fábio André |
author_role |
author |
author2 |
Cavalcanti, Marília Gabriela dos Santos Barbosa-Filho, José Maria Lúcio, Ana Silvia Suassuna Carneiro Veras, Dyana Leal Feitosa, Ana Paula Sampaio Siqueira Júnior, José Pinto de Almeida, Reinaldo Nóbrega de Marques, Márcia Ortiz Mayo Alves, Luiz Carlos Brayner, Fábio André |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Matos-Rocha, Thiago José Cavalcanti, Marília Gabriela dos Santos Barbosa-Filho, José Maria Lúcio, Ana Silvia Suassuna Carneiro Veras, Dyana Leal Feitosa, Ana Paula Sampaio Siqueira Júnior, José Pinto de Almeida, Reinaldo Nóbrega de Marques, Márcia Ortiz Mayo Alves, Luiz Carlos Brayner, Fábio André |
dc.subject.other.pt_BR.fl_str_mv |
Lamiaceae Mentha x villosa Schistosoma mansoni Atividade esquistossomicida Produtos naturais |
topic |
Lamiaceae Mentha x villosa Schistosoma mansoni Atividade esquistossomicida Produtos naturais Lamiaceae Mentha x villosa Schistosoma mansoni Schistosomicidal activity Natural products Animais Compostos bicíclicos em ponte / análise Compostos bicíclicos em ponte / farmacologia Ciclohexenos / análise Ciclohexenos / farmacologia Mentha / química Monoterpenos / análise Monoterpenos / farmacologia Óleos voláteis / química Óleos Voláteis / Farmacêuticos Extratos Vegetais / química Extratos Vegetais / Farmacologia Schistosoma mansoni / efeitos de drogas Esquistossomicidas / farmacologia Sesquiterpenos / análise Sesquiterpenos / farmacologia Terpenos / análise Terpenos / farmacologia |
dc.subject.en.pt_BR.fl_str_mv |
Lamiaceae Mentha x villosa Schistosoma mansoni Schistosomicidal activity Natural products |
dc.subject.decs.pt_BR.fl_str_mv |
Animais Compostos bicíclicos em ponte / análise Compostos bicíclicos em ponte / farmacologia Ciclohexenos / análise Ciclohexenos / farmacologia Mentha / química Monoterpenos / análise Monoterpenos / farmacologia Óleos voláteis / química Óleos Voláteis / Farmacêuticos Extratos Vegetais / química Extratos Vegetais / Farmacologia Schistosoma mansoni / efeitos de drogas Esquistossomicidas / farmacologia Sesquiterpenos / análise Sesquiterpenos / farmacologia Terpenos / análise Terpenos / farmacologia |
description |
LTF / UFPB, ao LIKA / UFPE e à FIOCRUZ-PE pelo apoio aos experimentos e à CAPES por uma bolsa de estudos. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2018-03-28T14:32:39Z |
dc.date.available.fl_str_mv |
2018-03-28T14:32:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MATOS-ROCHA, T. J. et al. In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni. Planta Medica, v. 79, n. 14, p. 1307–1312, set. 2013. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/25544 |
dc.identifier.issn.pt_BR.fl_str_mv |
1439-0221 |
dc.identifier.doi.none.fl_str_mv |
10.1055/s-0033-1350732 |
identifier_str_mv |
MATOS-ROCHA, T. J. et al. In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni. Planta Medica, v. 79, n. 14, p. 1307–1312, set. 2013. 1439-0221 10.1055/s-0033-1350732 |
url |
https://www.arca.fiocruz.br/handle/icict/25544 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1813008889061310464 |