Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase

Detalhes bibliográficos
Autor(a) principal: Faria Neto, Hugo Caire C.
Data de Publicação: 2005
Outros Autores: Stafforini, Diana M., Prescott, Stephen M., Zimmerman, Guy A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34332
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
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spelling Faria Neto, Hugo Caire C.Stafforini, Diana M.Prescott, Stephen M.Zimmerman, Guy A.2019-07-23T12:10:11Z2019-07-23T12:10:11Z2005FARIA NETO, Hugo Caire C. et al. Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. I, p. 83-91, 2005.0074-0276https://www.arca.fiocruz.br/handle/icict/3433210.1590/s0074-027620050009000141678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzSepseDoença inflamatóriaAcetil-hidrolaseFator de ativação de plaquetasPlatelet-activating factorAcethylhydrolaseInflammatory diseaseSepsisRegulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.University of Utah. The Huntsman Cancer Institute. Program in Human Molecular Biology and Genetics. Salt Lake City, UT, USA.University of Utah. The Huntsman Cancer Institute. Program in Human Molecular Biology and Genetics. Salt Lake City, UT, USA.University of Utah. The Huntsman Cancer Institute. Program in Human Molecular Biology and Genetics. Salt Lake City, UT, USA.Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity. Deacetylation induces the formation of the inactive metabolite lyso-PAF. This deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH), a calcium independent phospholipase A2 that also degrades a family of PAF-like oxidized phospholipids with short sn-2 residues. Biochemical and enzymological evaluations revealed that at least three types of PAF-AH exist in mammals, namely the intracellular types I and II and a plasma type. Many observations indicate that plasma PAF AH terminates signals by PAF and oxidized PAF-like lipids and thereby regulates inflammatory responses. In this review, we will focus on the potential of PAF-AH as a modulator of diseases of dysregulated inflammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALHugoCastro_FariaNeto_etal_IOC_2005.pdfHugoCastro_FariaNeto_etal_IOC_2005.pdfapplication/pdf92223https://www.arca.fiocruz.br/bitstream/icict/34332/2/HugoCastro_FariaNeto_etal_IOC_2005.pdfb32b8d86b411774386cf1b0858c716d6MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/34332/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTHugoCastro_FariaNeto_etal_IOC_2005.pdf.txtHugoCastro_FariaNeto_etal_IOC_2005.pdf.txtExtracted texttext/plain46342https://www.arca.fiocruz.br/bitstream/icict/34332/4/HugoCastro_FariaNeto_etal_IOC_2005.pdf.txta4085ef0635be6fd3003a463cfd52ceeMD54icict/343322019-07-26 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dc.title.pt_BR.fl_str_mv Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
title Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
spellingShingle Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
Faria Neto, Hugo Caire C.
Sepse
Doença inflamatória
Acetil-hidrolase
Fator de ativação de plaquetas
Platelet-activating factor
Acethylhydrolase
Inflammatory disease
Sepsis
title_short Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
title_full Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
title_fullStr Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
title_full_unstemmed Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
title_sort Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
author Faria Neto, Hugo Caire C.
author_facet Faria Neto, Hugo Caire C.
Stafforini, Diana M.
Prescott, Stephen M.
Zimmerman, Guy A.
author_role author
author2 Stafforini, Diana M.
Prescott, Stephen M.
Zimmerman, Guy A.
author2_role author
author
author
dc.contributor.author.fl_str_mv Faria Neto, Hugo Caire C.
Stafforini, Diana M.
Prescott, Stephen M.
Zimmerman, Guy A.
dc.subject.other.pt_BR.fl_str_mv Sepse
Doença inflamatória
Acetil-hidrolase
Fator de ativação de plaquetas
topic Sepse
Doença inflamatória
Acetil-hidrolase
Fator de ativação de plaquetas
Platelet-activating factor
Acethylhydrolase
Inflammatory disease
Sepsis
dc.subject.en.pt_BR.fl_str_mv Platelet-activating factor
Acethylhydrolase
Inflammatory disease
Sepsis
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2019-07-23T12:10:11Z
dc.date.available.fl_str_mv 2019-07-23T12:10:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FARIA NETO, Hugo Caire C. et al. Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. I, p. 83-91, 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34332
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/s0074-02762005000900014
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv FARIA NETO, Hugo Caire C. et al. Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. I, p. 83-91, 2005.
0074-0276
10.1590/s0074-02762005000900014
1678-8060
url https://www.arca.fiocruz.br/handle/icict/34332
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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