Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25533 |
Resumo: | National Council of Scientific and Technological Development (MCTI/CNPq/MS-SCTIE-Decit 40/2012; Research for Neglected Diseases grant 404129/2012-9). |
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Prates, Fernanda Ventim de OliveiraDourado, Mayra Elizabeth FerreiraSilva, Silvana Conceição daSchriefer, AlbertGuimarães, Luiz HenriqueBrito, Maria das Graças de OliveiraAlmeida, JulianaCarvalho Filho, Edgar MarcelinoMachado, Paulo Roberto Lima2018-03-27T18:02:26Z2018-03-27T18:02:26Z2017PRATES, F. V. O. et al. Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial. Clinical Infectious Diseases, v. 64, n. 1, p. 67–71, 2017.1058-4838https://www.arca.fiocruz.br/handle/icict/2553310.1093/cid/ciw662National Council of Scientific and Technological Development (MCTI/CNPq/MS-SCTIE-Decit 40/2012; Research for Neglected Diseases grant 404129/2012-9).Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil The treatment of cutaneous leishmaniasis (CL) caused by Leishmania braziliensis in Brazil with pentavalent antimony (Sbv) is associated with a high rate of failure, up to 45% of cases. In addition, Sbvcan only administered parenterally and has important toxic effect. An effective, safe, and oral treatment for CL is required. Methods. A randomized controlled clinical trial was conducted to compare the efficacy and safety of high-dosage oral fluconazole (6.5–8.0 mg/kg/d for 28 days) versus a standard Sbv protocol (20 mg/kg/d for 20 days) for the treatment of CL in Bahia, Brazil. Results. A total of 53 subjects were included in the trial; 26 were treated with Sbv, and 27 with fluconazole. Intention-to-treat analysis showed initial cure rates (2 months after treatment) of 22.2% (6 of 27) in the fluconazole and 53.8% (14 of 26) in the Sbv group (P = .04). Six months after treatment, the final cure rate remained the same in both groups, without any relapses. The frequencies of adverse effects in the Sbv and fluconazole groups were similar, 34.6% versus 37% respectively. One patient treated with fluconazole discontinued treatment owing to malaise, headache, and moderate dizziness (Common Terminology Criteria for Adverse Events grade 2). Conclusions. Oral fluconazole at a dosage of 6.5–8 mg/kg/d for 28 days should not be considered an effective treatment for CL caused by L. braziliensis.engOxford University PressLeishmaniose cutâneaFluconazolLeishmania (V.) braziliensisantimonio pentavalenteCutaneous leishmaniasisFluconazoleLeishmania (V.) braziliensisPentavalent antimonyFluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25533/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPrates FV Fluconazole in the Treatment of Cutaneous ....pdfPrates FV Fluconazole in the Treatment of Cutaneous 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dc.title.pt_BR.fl_str_mv |
Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial |
title |
Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial |
spellingShingle |
Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial Prates, Fernanda Ventim de Oliveira Leishmaniose cutânea Fluconazol Leishmania (V.) braziliensis antimonio pentavalente Cutaneous leishmaniasis Fluconazole Leishmania (V.) braziliensis Pentavalent antimony |
title_short |
Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial |
title_full |
Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial |
title_fullStr |
Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial |
title_full_unstemmed |
Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial |
title_sort |
Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial |
author |
Prates, Fernanda Ventim de Oliveira |
author_facet |
Prates, Fernanda Ventim de Oliveira Dourado, Mayra Elizabeth Ferreira Silva, Silvana Conceição da Schriefer, Albert Guimarães, Luiz Henrique Brito, Maria das Graças de Oliveira Almeida, Juliana Carvalho Filho, Edgar Marcelino Machado, Paulo Roberto Lima |
author_role |
author |
author2 |
Dourado, Mayra Elizabeth Ferreira Silva, Silvana Conceição da Schriefer, Albert Guimarães, Luiz Henrique Brito, Maria das Graças de Oliveira Almeida, Juliana Carvalho Filho, Edgar Marcelino Machado, Paulo Roberto Lima |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Prates, Fernanda Ventim de Oliveira Dourado, Mayra Elizabeth Ferreira Silva, Silvana Conceição da Schriefer, Albert Guimarães, Luiz Henrique Brito, Maria das Graças de Oliveira Almeida, Juliana Carvalho Filho, Edgar Marcelino Machado, Paulo Roberto Lima |
dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose cutânea Fluconazol Leishmania (V.) braziliensis antimonio pentavalente |
topic |
Leishmaniose cutânea Fluconazol Leishmania (V.) braziliensis antimonio pentavalente Cutaneous leishmaniasis Fluconazole Leishmania (V.) braziliensis Pentavalent antimony |
dc.subject.en.pt_BR.fl_str_mv |
Cutaneous leishmaniasis Fluconazole Leishmania (V.) braziliensis Pentavalent antimony |
description |
National Council of Scientific and Technological Development (MCTI/CNPq/MS-SCTIE-Decit 40/2012; Research for Neglected Diseases grant 404129/2012-9). |
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2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2018-03-27T18:02:26Z |
dc.date.available.fl_str_mv |
2018-03-27T18:02:26Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
PRATES, F. V. O. et al. Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial. Clinical Infectious Diseases, v. 64, n. 1, p. 67–71, 2017. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/25533 |
dc.identifier.issn.pt_BR.fl_str_mv |
1058-4838 |
dc.identifier.doi.none.fl_str_mv |
10.1093/cid/ciw662 |
identifier_str_mv |
PRATES, F. V. O. et al. Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial. Clinical Infectious Diseases, v. 64, n. 1, p. 67–71, 2017. 1058-4838 10.1093/cid/ciw662 |
url |
https://www.arca.fiocruz.br/handle/icict/25533 |
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eng |
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eng |
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Oxford University Press |
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Oxford University Press |
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