HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women

Detalhes bibliográficos
Autor(a) principal: Valverde, Suellen Pinheiro Carvalho
Data de Publicação: 2022
Outros Autores: Yahouédéhou, Setondji Cocou Modeste Alexandre, Oliveira, Rodrigo Mota de, Veloso, Nathalie Souza, Fonseca, Cleverson Alves, Mendes, Karina Oliveira, Barbosa, Cynara Gomes, Gonçalves, Marilda de Souza, Adôrno, Elisângela Vitória
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/60818
Resumo: Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES).
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spelling Valverde, Suellen Pinheiro CarvalhoYahouédéhou, Setondji Cocou Modeste AlexandreOliveira, Rodrigo Mota deVeloso, Nathalie SouzaFonseca, Cleverson AlvesMendes, Karina OliveiraBarbosa, Cynara GomesGonçalves, Marilda de SouzaAdôrno, Elisângela Vitória2023-10-17T13:23:48Z2023-10-17T13:23:48Z2022VALVERDE, Suellen Pinheiro Carvalho et al. HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women. Open Journal of Pain Medicine, v. 6, n. 1, p. 1-7, 2022.2640-8104https://www.arca.fiocruz.br/handle/icict/6081810.17352/ojpm.000029Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES).Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Reports describe the association between platelet activation, adhesion, and aggregation, as well as polymorphisms in genes encoding platelet membrane glycoproteins with a predisposition to coronary artery disease (CAD). This study investigates associations between HPA-1, -3 and C807T polymorphisms and CAD. A cross-sectional study involving 114 women who underwent coronary angiography was performed. The CAD+ group consisted of 63 women while the CAD- group of 51 women. Hematological and biochemical parameters were evaluated by electronic methods. Polymorphisms were investigated by PCR-RFLP and PCR-SSP and participants answered an epidemiological questionnaire and provided anthropometric data. Blood pressure was also measured. Statistical analyses were performed using EpiInfo v. 7.0 software. Results showed that age, diabetes mellitus, hypertension, and hyperlipidemia were associated with CAD. In addition, CAD+ women showed elevated glucose, TG, and VLDL-c levels and reduced HDL-c levels. No significant difference was observed between the allelic and genotypic distributions of the polymorphisms HPA-1, -3, and C807T in CAD+ and CAD- groups. However, CAD+ women carriers of the variant 3b allele had elevated TG and sP-selectin levels while the carriers of the variant 807T allele had reduced CT and LDL-c levels. Hence, our data suggest that the polymorphism HPA-3 increases, indirectly, the risk of CAD development and occurrence while polymorphism C807T reduces this effec.engPeertechz Publications Private LimitedHPA-3C807TPolimorfismosBiomarcadoresArtéria coronáriaMulheres brasileirasHPA-3C807TPolymorphismsBiomarkersCoronary arteryBrazilian womenBiomarcadoresDoença da Artéria CoronarianaMulheresHPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60818/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALValverde, S. P. C. - HPA-3 and C807T polymorphisms are associated with laboratory biomarkers.pdfValverde, S. P. C. - HPA-3 and C807T polymorphisms are associated with laboratory biomarkers.pdfapplication/pdf286865https://www.arca.fiocruz.br/bitstream/icict/60818/2/Valverde%2c%20S.%20P.%20C.%20-%20HPA-3%20and%20C807T%20polymorphisms%20are%20associated%20with%20laboratory%20biomarkers.pdf9f9ed253b5a3c906bb2483133266b757MD52icict/608182023-10-17 10:23:49.469oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-10-17T13:23:49Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women
title HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women
spellingShingle HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women
Valverde, Suellen Pinheiro Carvalho
HPA-3
C807T
Polimorfismos
Biomarcadores
Artéria coronária
Mulheres brasileiras
HPA-3
C807T
Polymorphisms
Biomarkers
Coronary artery
Brazilian women
Biomarcadores
Doença da Artéria Coronariana
Mulheres
title_short HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women
title_full HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women
title_fullStr HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women
title_full_unstemmed HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women
title_sort HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women
author Valverde, Suellen Pinheiro Carvalho
author_facet Valverde, Suellen Pinheiro Carvalho
Yahouédéhou, Setondji Cocou Modeste Alexandre
Oliveira, Rodrigo Mota de
Veloso, Nathalie Souza
Fonseca, Cleverson Alves
Mendes, Karina Oliveira
Barbosa, Cynara Gomes
Gonçalves, Marilda de Souza
Adôrno, Elisângela Vitória
author_role author
author2 Yahouédéhou, Setondji Cocou Modeste Alexandre
Oliveira, Rodrigo Mota de
Veloso, Nathalie Souza
Fonseca, Cleverson Alves
Mendes, Karina Oliveira
Barbosa, Cynara Gomes
Gonçalves, Marilda de Souza
Adôrno, Elisângela Vitória
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Valverde, Suellen Pinheiro Carvalho
Yahouédéhou, Setondji Cocou Modeste Alexandre
Oliveira, Rodrigo Mota de
Veloso, Nathalie Souza
Fonseca, Cleverson Alves
Mendes, Karina Oliveira
Barbosa, Cynara Gomes
Gonçalves, Marilda de Souza
Adôrno, Elisângela Vitória
dc.subject.other.en_US.fl_str_mv HPA-3
C807T
Polimorfismos
Biomarcadores
Artéria coronária
Mulheres brasileiras
topic HPA-3
C807T
Polimorfismos
Biomarcadores
Artéria coronária
Mulheres brasileiras
HPA-3
C807T
Polymorphisms
Biomarkers
Coronary artery
Brazilian women
Biomarcadores
Doença da Artéria Coronariana
Mulheres
dc.subject.en.en_US.fl_str_mv HPA-3
C807T
Polymorphisms
Biomarkers
Coronary artery
Brazilian women
dc.subject.decs.en_US.fl_str_mv Biomarcadores
Doença da Artéria Coronariana
Mulheres
description Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES).
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-10-17T13:23:48Z
dc.date.available.fl_str_mv 2023-10-17T13:23:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv VALVERDE, Suellen Pinheiro Carvalho et al. HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women. Open Journal of Pain Medicine, v. 6, n. 1, p. 1-7, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/60818
dc.identifier.issn.en_US.fl_str_mv 2640-8104
dc.identifier.doi.none.fl_str_mv 10.17352/ojpm.000029
identifier_str_mv VALVERDE, Suellen Pinheiro Carvalho et al. HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women. Open Journal of Pain Medicine, v. 6, n. 1, p. 1-7, 2022.
2640-8104
10.17352/ojpm.000029
url https://www.arca.fiocruz.br/handle/icict/60818
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Peertechz Publications Private Limited
publisher.none.fl_str_mv Peertechz Publications Private Limited
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/60818/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/60818/2/Valverde%2c%20S.%20P.%20C.%20-%20HPA-3%20and%20C807T%20polymorphisms%20are%20associated%20with%20laboratory%20biomarkers.pdf
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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