Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48518 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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Corrêa, Jessica BadolatoCarvalho, Fabiana RabePaiva, Iuri AmancioMacedo, Débora FamiliarDias, Helver GonçalvesCorrêa, Alex PauvolidSantos, Caroline FernandesLima, Monique da Rocha QueirozGandini, MarianaSilva, Andréa AliceCavalcanti, Silvia Maria BaetaOliveira, Solange Artimos deVianna, Renata Artimos de OliveiraAzeredo, Elzinandes Leal deCardoso, Claudete Aparecida AraújoGrifoni, AlbaSette, AlessandroWeiskopf, DanielaPInto, Luzia Maria de Oliveira2021-08-09T18:51:57Z2021-08-09T18:51:57Z2021CORRÊA, Jessica Badolato et al. Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children. Frontiers in immunology, v. 12, Article 610456, p. 1-17, Feb. 2021.1664-3224https://www.arca.fiocruz.br/handle/icict/4851810.3389/fimmu.2021.610456engFrontiers MediaZikaCélulas TMemóriaGravidezSíndrome congênita do ZikaZikaT cellsMemoryPregnancyCongenital Zika syndrome (CZS)Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Escola de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Department of Veterinary Integrative Biosciences, Texas A&M University, College Station. TX, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Escola de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Laboratório de Diagnóstico Virológico. Niterói, RJ, Brasil.Universidade Federal Fluminense. Escola de Medicina. Departamento Materno Infantil. Niterói, RJ, Brasil.Universidade Federal Fluminense. Escola de Medicina. Departamento Materno Infantil. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Escola de Medicina. Laboratório Multiusuário para Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil / Universidade Federal Fluminense. Escola de Medicina. Departamento Materno Infantil. Niterói, RJ, Brasil.Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI). San Diego, CA, USA.Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI). San Diego, CA, USA / Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, San Diego, CA, USA.Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI). San Diego, CA, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Background: Zika virus (ZIKV) infection causes for mild and self-limiting disease in healthy adults. In newborns, it can occasionally lead to a spectrum of malformations, the congenital Zika syndrome (CZS). Thus, little is known if mothers and babies with a history of ZIKV infection were able to develop long-lasting T-cell immunity. To these issues, we measure the prevalence of ZIKV T-cell immunity in a cohort of mothers infected to the ZIKV during pregnancy in the 2016–2017 Zika outbreak, who gave birth to infants affected by neurological complications or asymptomatic ones. Results: Twenty-one mothers and 18 children were tested for IFN-γ ELISpot and T-cell responses for flow cytometry assays in response to CD4 ZIKV and CD8 ZIKV megapools (CD4 ZIKV MP and CD8 ZIKV MP). IFN-γ ELISpot responses to ZIKV MPs showed an increased CD4 and CD8 T-cell responses in mothers compared to children. The degranulation activity and IFN-γ-producing CD4 T cells were detected in most mothers, and children, while in CD8 T-cells, low responses were detected in these study groups. The total Temra T cell subset is enriched for IFN-γ+ CD4 T cells after stimulation of CD4 ZIKV MP. Conclusion: Donors with a history of ZIKV infection demonstrated long-term CD4 T cell immunity to ZIKV CD4 MP. However, the same was not observed in CD8 T cells with the ZIKV CD8 MP. One possibility is that the cytotoxic and pro-inflammatory activities of CD8 T cells are markedly demonstrated in the early stages of infection, but less detected in the disease resolution phase, when the virus has already been eliminated. The Background: Zika virus (ZIKV) infection causes for mild and self-limiting disease in healthy adults. In newborns, it can occasionally lead to a spectrum of malformations, the congenital Zika syndrome (CZS). Thus, little is known if mothers and babies with a history of ZIKV infection were able to develop long-lasting T-cell immunity. To these issues, we measure the prevalence of ZIKV T-cell immunity in a cohort of mothers infected to the ZIKV during pregnancy in the 2016–2017 Zika outbreak, who gave birth to infants affected by neurological complications or asymptomatic ones. Results: Twenty-one mothers and 18 children were tested for IFN-γ ELISpot and T-cell responses for flow cytometry assays in response to CD4 ZIKV and CD8 ZIKV megapools (CD4 ZIKV MP and CD8 ZIKV MP). IFN-γ ELISpot responses to ZIKV MPs showed an increased CD4 and CD8 T-cell responses in mothers compared to children. The degranulation activity and IFN-γ-producing CD4 T cells were detected in most mothers, and children, while in CD8 T-cells, low responses were detected in these study groups. The total Temra T cell subset is enriched for IFN-γ+ CD4 T cells after stimulation of CD4 ZIKV MP. Conclusion: Donors with a history of ZIKV infection demonstrated long-term CD4 T cell immunity to ZIKV CD4 MP. However, the same was not observed in CD8 T cells with the ZIKV CD8 MP. One possibility is that the cytotoxic and pro-inflammatory activities of CD8 T cells are markedly demonstrated in the early stages of infection, but less detected in the disease resolution phase, when the virus has already been eliminated. The Background: Zika virus (ZIKV) infection causes for mild and self-limiting disease in healthy adults. In newborns, it can occasionally lead to a spectrum of malformations, the congenital Zika syndrome (CZS). Thus, little is known if mothers and babies with a history of ZIKV infection were able to develop long-lasting T-cell immunity. To these issues, we measure the prevalence of ZIKV T-cell immunity in a cohort of mothers infected to the ZIKV during pregnancy in the 2016–2017 Zika outbreak, who gave birth to infants affected by neurological complications or asymptomatic ones. Results: Twenty-one mothers and 18 children were tested for IFN-γ ELISpot and T-cell responses for flow cytometry assays in response to CD4 ZIKV and CD8 ZIKV megapools (CD4 ZIKV MP and CD8 ZIKV MP). IFN-γ ELISpot responses to ZIKV MPs showed an increased CD4 and CD8 T-cell responses in mothers compared to children. The degranulation activity and IFN-γ-producing CD4 T cells were detected in most mothers, and children, while in CD8 T-cells, low responses were detected in these study groups. The total Temra T cell subset is enriched for IFN-γ+ CD4 T cells after stimulation of CD4 ZIKV MP. Conclusion: Donors with a history of ZIKV infection demonstrated long-term CD4 T cell immunity to ZIKV CD4 MP. However, the same was not observed in CD8 T cells with the ZIKV CD8 MP. One possibility is that the cytotoxic and pro-inflammatory activities of CD8 T cells are markedly demonstrated in the early stages of infection, but less detected in the disease resolution phase, when the virus has already been eliminated. The responses of mothers’ T cells to ZIKV MPs do not appear to be related to their children’s clinical outcome. There was also no marked difference in the T cell responses to ZIKV MP between children affected or not with CZS. These data still need to be investigated, including the evaluation of the response of CD8 T cells to other ZIKV peptides.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48518/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDeboraMacedo_LuziaPinto_etal_IOC_2021.pdfDeboraMacedo_LuziaPinto_etal_IOC_2021.pdfapplication/pdf12025611https://www.arca.fiocruz.br/bitstream/icict/48518/2/DeboraMacedo_LuziaPinto_etal_IOC_2021.pdfa28a7e374d9c8e0b6e81327b592a4730MD52TEXTDeboraMacedo_LuziaPinto_etal_IOC_2021.pdf.txtDeboraMacedo_LuziaPinto_etal_IOC_2021.pdf.txtExtracted texttext/plain81813https://www.arca.fiocruz.br/bitstream/icict/48518/3/DeboraMacedo_LuziaPinto_etal_IOC_2021.pdf.txt2907ac4dba5b0c2c9552367b2904168bMD53icict/485182021-10-17 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| dc.title.pt_BR.fl_str_mv |
Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children |
| title |
Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children |
| spellingShingle |
Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children Corrêa, Jessica Badolato Zika Células T Memória Gravidez Síndrome congênita do Zika Zika T cells Memory Pregnancy Congenital Zika syndrome (CZS) |
| title_short |
Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children |
| title_full |
Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children |
| title_fullStr |
Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children |
| title_full_unstemmed |
Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children |
| title_sort |
Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children |
| author |
Corrêa, Jessica Badolato |
| author_facet |
Corrêa, Jessica Badolato Carvalho, Fabiana Rabe Paiva, Iuri Amancio Macedo, Débora Familiar Dias, Helver Gonçalves Corrêa, Alex Pauvolid Santos, Caroline Fernandes Lima, Monique da Rocha Queiroz Gandini, Mariana Silva, Andréa Alice Cavalcanti, Silvia Maria Baeta Oliveira, Solange Artimos de Vianna, Renata Artimos de Oliveira Azeredo, Elzinandes Leal de Cardoso, Claudete Aparecida Araújo Grifoni, Alba Sette, Alessandro Weiskopf, Daniela PInto, Luzia Maria de Oliveira |
| author_role |
author |
| author2 |
Carvalho, Fabiana Rabe Paiva, Iuri Amancio Macedo, Débora Familiar Dias, Helver Gonçalves Corrêa, Alex Pauvolid Santos, Caroline Fernandes Lima, Monique da Rocha Queiroz Gandini, Mariana Silva, Andréa Alice Cavalcanti, Silvia Maria Baeta Oliveira, Solange Artimos de Vianna, Renata Artimos de Oliveira Azeredo, Elzinandes Leal de Cardoso, Claudete Aparecida Araújo Grifoni, Alba Sette, Alessandro Weiskopf, Daniela PInto, Luzia Maria de Oliveira |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Corrêa, Jessica Badolato Carvalho, Fabiana Rabe Paiva, Iuri Amancio Macedo, Débora Familiar Dias, Helver Gonçalves Corrêa, Alex Pauvolid Santos, Caroline Fernandes Lima, Monique da Rocha Queiroz Gandini, Mariana Silva, Andréa Alice Cavalcanti, Silvia Maria Baeta Oliveira, Solange Artimos de Vianna, Renata Artimos de Oliveira Azeredo, Elzinandes Leal de Cardoso, Claudete Aparecida Araújo Grifoni, Alba Sette, Alessandro Weiskopf, Daniela PInto, Luzia Maria de Oliveira |
| dc.subject.other.pt_BR.fl_str_mv |
Zika Células T Memória Gravidez Síndrome congênita do Zika |
| topic |
Zika Células T Memória Gravidez Síndrome congênita do Zika Zika T cells Memory Pregnancy Congenital Zika syndrome (CZS) |
| dc.subject.en.pt_BR.fl_str_mv |
Zika T cells Memory Pregnancy Congenital Zika syndrome (CZS) |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2021 |
| dc.date.accessioned.fl_str_mv |
2021-08-09T18:51:57Z |
| dc.date.available.fl_str_mv |
2021-08-09T18:51:57Z |
| dc.date.issued.fl_str_mv |
2021 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
CORRÊA, Jessica Badolato et al. Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children. Frontiers in immunology, v. 12, Article 610456, p. 1-17, Feb. 2021. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/48518 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2021.610456 |
| identifier_str_mv |
CORRÊA, Jessica Badolato et al. Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children. Frontiers in immunology, v. 12, Article 610456, p. 1-17, Feb. 2021. 1664-3224 10.3389/fimmu.2021.610456 |
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https://www.arca.fiocruz.br/handle/icict/48518 |
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eng |
| language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
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Frontiers Media |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
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repositorio.arca@fiocruz.br |
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