Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Lyra, Marcelo Rosandiski
Data de Publicação: 2016
Outros Autores: Passos, Sonia Regina Lambert, Pimentel, Maria Inês Fernandes, Bedoya-Pacheco, Sandro Javier, Rosalino, Cláudia Maria Valete, Vasconcellos, Erica Camargo Ferreira, Antonio, Liliane Fatima, Saheki, Mauricio Naoto, Salgueiro, Mariza Mattos, Santos, Ginelza Peres Lima, Ribeiro, Madelon Noato, Silva, Fátima Conceição, Madeira, Maria Fatima, Silva, Jorge Luiz Nunes, Fagundes, Aline, Schubach, Armando Oliveria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16569
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.
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spelling Lyra, Marcelo RosandiskiPassos, Sonia Regina LambertPimentel, Maria Inês FernandesBedoya-Pacheco, Sandro JavierRosalino, Cláudia Maria ValeteVasconcellos, Erica Camargo FerreiraAntonio, Liliane FatimaSaheki, Mauricio NaotoSalgueiro, Mariza MattosSantos, Ginelza Peres LimaRibeiro, Madelon NoatoSilva, Fátima ConceiçãoMadeira, Maria FatimaSilva, Jorge Luiz NunesFagundes, AlineSchubach, Armando Oliveria2016-12-27T11:13:55Z2016-12-27T11:13:55Z2016LIRA, Marcelo Rosandiski et al. Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis. Revista do Instituto de Medicina Tropical de São Paulo, v. 58, n. 68, p. 1-6, 2016.0036-4665https://www.arca.fiocruz.br/handle/icict/1656910.1590/S1678-99462016580681678-9946engUniversidade de São PauloLieshmaniose cutâneaTerapiaPancreatiteEnsaio ClínicoAntimoniato de megluminaCutaneous leishmaniasisTherapyClinical trialMeglumine antimoniatePancreatitisPancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Epidemiologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz (FIOCRUZ). Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.American tegumentary leishmaniasis is an infectious disease caused by a protozoan of the genus Leishmania. Pentavalent antimonials are the first choice drugs for cutaneous leishmaniasis (CL), although doses are controversial. In a clinical trial for CL we investigated the occurrence of pancreatic toxicity with different schedules of treatment with meglumine antimoniate (MA). Seventy-two patients were allocated in two different therapeutic groups: 20 or 5 mg of pentavalent antimony (Sb5+)/kg/day for 20 or 30 days, respectively. Looking for adverse effects, patients were asked about abdominal pain, nausea, vomiting or anorexia in each medical visit. We performed physical examinations and collected blood to evaluate serum amylase and lipase in the pre-treatment period, and every 10 days during treatment and one month post-treatment. Hyperlipasemia occurred in 54.8% and hyperamylasemia in 19.4% patients. Patients treated with MA 20 mg Sb5+ presented a higher risk of hyperlipasemia (p = 0.023). Besides, higher MA doses were associated with a 2.05 higher risk ratio (p = 0.003) of developing more serious (moderate to severe) hyperlipasemia. The attributable fraction was 51% in this group. Thirty-six patients presented abdominal pain, nausea, vomiting or anorexia but only 47.2% of those had hyperlipasemia and/ or hyperamylasemia. These findings suggest the importance of the search for less toxic therapeutic regimens for the treatment of CL.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16569/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALfatima_silva_etal_IOC_2016.pdffatima_silva_etal_IOC_2016.pdfapplication/pdf112932https://www.arca.fiocruz.br/bitstream/icict/16569/2/fatima_silva_etal_IOC_2016.pdf233a7fb3d4c489237c45cf9f4a61d544MD52TEXTfatima_silva_etal_IOC_2016.pdf.txtfatima_silva_etal_IOC_2016.pdf.txtExtracted texttext/plain32378https://www.arca.fiocruz.br/bitstream/icict/16569/3/fatima_silva_etal_IOC_2016.pdf.txt197b866df561b8e21ad10549a2c1c6e9MD53icict/165692023-10-25 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dc.title.pt_BR.fl_str_mv Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis
title Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis
spellingShingle Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis
Lyra, Marcelo Rosandiski
Lieshmaniose cutânea
Terapia
Pancreatite
Ensaio Clínico
Antimoniato de meglumina
Cutaneous leishmaniasis
Therapy
Clinical trial
Meglumine antimoniate
Pancreatitis
title_short Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis
title_full Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis
title_fullStr Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis
title_full_unstemmed Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis
title_sort Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis
author Lyra, Marcelo Rosandiski
author_facet Lyra, Marcelo Rosandiski
Passos, Sonia Regina Lambert
Pimentel, Maria Inês Fernandes
Bedoya-Pacheco, Sandro Javier
Rosalino, Cláudia Maria Valete
Vasconcellos, Erica Camargo Ferreira
Antonio, Liliane Fatima
Saheki, Mauricio Naoto
Salgueiro, Mariza Mattos
Santos, Ginelza Peres Lima
Ribeiro, Madelon Noato
Silva, Fátima Conceição
Madeira, Maria Fatima
Silva, Jorge Luiz Nunes
Fagundes, Aline
Schubach, Armando Oliveria
author_role author
author2 Passos, Sonia Regina Lambert
Pimentel, Maria Inês Fernandes
Bedoya-Pacheco, Sandro Javier
Rosalino, Cláudia Maria Valete
Vasconcellos, Erica Camargo Ferreira
Antonio, Liliane Fatima
Saheki, Mauricio Naoto
Salgueiro, Mariza Mattos
Santos, Ginelza Peres Lima
Ribeiro, Madelon Noato
Silva, Fátima Conceição
Madeira, Maria Fatima
Silva, Jorge Luiz Nunes
Fagundes, Aline
Schubach, Armando Oliveria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lyra, Marcelo Rosandiski
Passos, Sonia Regina Lambert
Pimentel, Maria Inês Fernandes
Bedoya-Pacheco, Sandro Javier
Rosalino, Cláudia Maria Valete
Vasconcellos, Erica Camargo Ferreira
Antonio, Liliane Fatima
Saheki, Mauricio Naoto
Salgueiro, Mariza Mattos
Santos, Ginelza Peres Lima
Ribeiro, Madelon Noato
Silva, Fátima Conceição
Madeira, Maria Fatima
Silva, Jorge Luiz Nunes
Fagundes, Aline
Schubach, Armando Oliveria
dc.subject.other.pt_BR.fl_str_mv Lieshmaniose cutânea
Terapia
Pancreatite
Ensaio Clínico
Antimoniato de meglumina
topic Lieshmaniose cutânea
Terapia
Pancreatite
Ensaio Clínico
Antimoniato de meglumina
Cutaneous leishmaniasis
Therapy
Clinical trial
Meglumine antimoniate
Pancreatitis
dc.subject.en.pt_BR.fl_str_mv Cutaneous leishmaniasis
Therapy
Clinical trial
Meglumine antimoniate
Pancreatitis
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-27T11:13:55Z
dc.date.available.fl_str_mv 2016-12-27T11:13:55Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIRA, Marcelo Rosandiski et al. Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis. Revista do Instituto de Medicina Tropical de São Paulo, v. 58, n. 68, p. 1-6, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16569
dc.identifier.issn.pt_BR.fl_str_mv 0036-4665
dc.identifier.doi.none.fl_str_mv 10.1590/S1678-9946201658068
dc.identifier.eissn.none.fl_str_mv 1678-9946
identifier_str_mv LIRA, Marcelo Rosandiski et al. Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis. Revista do Instituto de Medicina Tropical de São Paulo, v. 58, n. 68, p. 1-6, 2016.
0036-4665
10.1590/S1678-9946201658068
1678-9946
url https://www.arca.fiocruz.br/handle/icict/16569
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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