Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16569 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil. |
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Lyra, Marcelo RosandiskiPassos, Sonia Regina LambertPimentel, Maria Inês FernandesBedoya-Pacheco, Sandro JavierRosalino, Cláudia Maria ValeteVasconcellos, Erica Camargo FerreiraAntonio, Liliane FatimaSaheki, Mauricio NaotoSalgueiro, Mariza MattosSantos, Ginelza Peres LimaRibeiro, Madelon NoatoSilva, Fátima ConceiçãoMadeira, Maria FatimaSilva, Jorge Luiz NunesFagundes, AlineSchubach, Armando Oliveria2016-12-27T11:13:55Z2016-12-27T11:13:55Z2016LIRA, Marcelo Rosandiski et al. Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis. Revista do Instituto de Medicina Tropical de São Paulo, v. 58, n. 68, p. 1-6, 2016.0036-4665https://www.arca.fiocruz.br/handle/icict/1656910.1590/S1678-99462016580681678-9946engUniversidade de São PauloLieshmaniose cutâneaTerapiaPancreatiteEnsaio ClínicoAntimoniato de megluminaCutaneous leishmaniasisTherapyClinical trialMeglumine antimoniatePancreatitisPancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Epidemiologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz (FIOCRUZ). Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Rio de Janeiro, RJ, Brasil / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.American tegumentary leishmaniasis is an infectious disease caused by a protozoan of the genus Leishmania. Pentavalent antimonials are the first choice drugs for cutaneous leishmaniasis (CL), although doses are controversial. In a clinical trial for CL we investigated the occurrence of pancreatic toxicity with different schedules of treatment with meglumine antimoniate (MA). Seventy-two patients were allocated in two different therapeutic groups: 20 or 5 mg of pentavalent antimony (Sb5+)/kg/day for 20 or 30 days, respectively. Looking for adverse effects, patients were asked about abdominal pain, nausea, vomiting or anorexia in each medical visit. We performed physical examinations and collected blood to evaluate serum amylase and lipase in the pre-treatment period, and every 10 days during treatment and one month post-treatment. Hyperlipasemia occurred in 54.8% and hyperamylasemia in 19.4% patients. Patients treated with MA 20 mg Sb5+ presented a higher risk of hyperlipasemia (p = 0.023). Besides, higher MA doses were associated with a 2.05 higher risk ratio (p = 0.003) of developing more serious (moderate to severe) hyperlipasemia. The attributable fraction was 51% in this group. Thirty-six patients presented abdominal pain, nausea, vomiting or anorexia but only 47.2% of those had hyperlipasemia and/ or hyperamylasemia. These findings suggest the importance of the search for less toxic therapeutic regimens for the treatment of CL.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16569/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALfatima_silva_etal_IOC_2016.pdffatima_silva_etal_IOC_2016.pdfapplication/pdf112932https://www.arca.fiocruz.br/bitstream/icict/16569/2/fatima_silva_etal_IOC_2016.pdf233a7fb3d4c489237c45cf9f4a61d544MD52TEXTfatima_silva_etal_IOC_2016.pdf.txtfatima_silva_etal_IOC_2016.pdf.txtExtracted texttext/plain32378https://www.arca.fiocruz.br/bitstream/icict/16569/3/fatima_silva_etal_IOC_2016.pdf.txt197b866df561b8e21ad10549a2c1c6e9MD53icict/165692023-10-25 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dc.title.pt_BR.fl_str_mv |
Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis |
title |
Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis |
spellingShingle |
Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis Lyra, Marcelo Rosandiski Lieshmaniose cutânea Terapia Pancreatite Ensaio Clínico Antimoniato de meglumina Cutaneous leishmaniasis Therapy Clinical trial Meglumine antimoniate Pancreatitis |
title_short |
Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis |
title_full |
Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis |
title_fullStr |
Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis |
title_full_unstemmed |
Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis |
title_sort |
Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis |
author |
Lyra, Marcelo Rosandiski |
author_facet |
Lyra, Marcelo Rosandiski Passos, Sonia Regina Lambert Pimentel, Maria Inês Fernandes Bedoya-Pacheco, Sandro Javier Rosalino, Cláudia Maria Valete Vasconcellos, Erica Camargo Ferreira Antonio, Liliane Fatima Saheki, Mauricio Naoto Salgueiro, Mariza Mattos Santos, Ginelza Peres Lima Ribeiro, Madelon Noato Silva, Fátima Conceição Madeira, Maria Fatima Silva, Jorge Luiz Nunes Fagundes, Aline Schubach, Armando Oliveria |
author_role |
author |
author2 |
Passos, Sonia Regina Lambert Pimentel, Maria Inês Fernandes Bedoya-Pacheco, Sandro Javier Rosalino, Cláudia Maria Valete Vasconcellos, Erica Camargo Ferreira Antonio, Liliane Fatima Saheki, Mauricio Naoto Salgueiro, Mariza Mattos Santos, Ginelza Peres Lima Ribeiro, Madelon Noato Silva, Fátima Conceição Madeira, Maria Fatima Silva, Jorge Luiz Nunes Fagundes, Aline Schubach, Armando Oliveria |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lyra, Marcelo Rosandiski Passos, Sonia Regina Lambert Pimentel, Maria Inês Fernandes Bedoya-Pacheco, Sandro Javier Rosalino, Cláudia Maria Valete Vasconcellos, Erica Camargo Ferreira Antonio, Liliane Fatima Saheki, Mauricio Naoto Salgueiro, Mariza Mattos Santos, Ginelza Peres Lima Ribeiro, Madelon Noato Silva, Fátima Conceição Madeira, Maria Fatima Silva, Jorge Luiz Nunes Fagundes, Aline Schubach, Armando Oliveria |
dc.subject.other.pt_BR.fl_str_mv |
Lieshmaniose cutânea Terapia Pancreatite Ensaio Clínico Antimoniato de meglumina |
topic |
Lieshmaniose cutânea Terapia Pancreatite Ensaio Clínico Antimoniato de meglumina Cutaneous leishmaniasis Therapy Clinical trial Meglumine antimoniate Pancreatitis |
dc.subject.en.pt_BR.fl_str_mv |
Cutaneous leishmaniasis Therapy Clinical trial Meglumine antimoniate Pancreatitis |
description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil. |
publishDate |
2016 |
dc.date.accessioned.fl_str_mv |
2016-12-27T11:13:55Z |
dc.date.available.fl_str_mv |
2016-12-27T11:13:55Z |
dc.date.issued.fl_str_mv |
2016 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LIRA, Marcelo Rosandiski et al. Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis. Revista do Instituto de Medicina Tropical de São Paulo, v. 58, n. 68, p. 1-6, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/16569 |
dc.identifier.issn.pt_BR.fl_str_mv |
0036-4665 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S1678-9946201658068 |
dc.identifier.eissn.none.fl_str_mv |
1678-9946 |
identifier_str_mv |
LIRA, Marcelo Rosandiski et al. Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis. Revista do Instituto de Medicina Tropical de São Paulo, v. 58, n. 68, p. 1-6, 2016. 0036-4665 10.1590/S1678-9946201658068 1678-9946 |
url |
https://www.arca.fiocruz.br/handle/icict/16569 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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collection |
Repositório Institucional da FIOCRUZ (ARCA) |
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