Piper anisum as a promising new source of bioactive metabolites
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42260 |
Resumo: | Federal University of Bahia (Project no: 11301), FAPESB, CNPq and CAPES. |
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Batista, DaniloCampos, PatríciaSilva, Valdenizia RodriguesSantos, Luciano de S.Bezerra, Daniel PereiraSoares, Milena Botelho PereiraColepicolo, PioVillela, Leonardo ZambottiPinto, ErnaniAraújo, Floricea MMartins, DirceuFernandez, Luzimar GLigterink, WilcoCanuto, Gisele A. BCerqueira·, Martins Dias deRibeiro, Paulo R2020-07-15T12:54:07Z2020-07-15T12:54:07Z2020BATISTA, Danilo et al. Piper anisum as a promising new source of bioactive metabolites. Chemical Papers, v. 74, p. 1505–1515, 2020.0366-6352https://www.arca.fiocruz.br/handle/icict/42260Federal University of Bahia (Project no: 11301), FAPESB, CNPq and CAPES.Universidade Federal da Bahia. Instituto de Química. Metabolomics Research Group. Departamento de Química Orgânica. Salvador, BA, Brasil.Universidade Federal da Bahia. Departamento de Bioquímica e Biofísica. Laboratório de Bioquímica, Biotecnologia e Bioprodutos. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade de São Paulo. Instituto de Química .Departamento de Bioquímica. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Química .Departamento de Bioquímica. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. São Paulo, SP, Brasil.Universidade Federal da Bahia. Instituto de Química. Metabolomics Research Group. Departamento de Química Orgânica. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Química. Metabolomics Research Group. Departamento de Química Orgânica. Salvador, BA, Brasil.Universidade Federal da Bahia. Departamento de Bioquímica e Biofísica. Laboratório de Bioquímica, Biotecnologia e Bioprodutos. Salvador, BA, Brasil.Wageningen University. Wageningen Seed Lab. Laboratory of Plant Physiology. Droevendaalsesteeg, The Netherlands.Universidade Federal da Bahia. Instituto de Química. Metabolomics Research Group. Departamento de Química Orgânica. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Química. Metabolomics Research Group. Departamento de Química Orgânica. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Química. Metabolomics Research Group. Departamento de Química Orgânica. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Bioquímica e Biofísica. Laboratório de Bioquímica, Biotecnologia e Bioprodutos. Salvador, BA, Brasil.Piper species are commonly used by indigenous communities to treat several gastrointestinal diseases. In China, they are also used as an active ingredient in formulae to treat cancer. The objective of the study was to perform a large-scale metabolite profiling analysis to identify bioactive compounds in Piper anisum. Antioxidant capacity was assessed by the DPPH assay and total phenolics were assessed by Folin–Ciocalteu’s method. Antimicrobial activity was assessed against several Grampositive and Gram-negative bacteria, whereas cytotoxicity was assessed against tumor cell lines MCF-7, HCT116, HepG2 and HL-60, and non-tumor cell line MRC-5. The multiplatform metabolite profiling approach encompassed NMR, GC–MS and LC–MS analyses. P. anisum root extract showed the greatest antioxidant capacity and total phenolic content, followed by the stem and leaf extracts. P. anisum extracts showed a highly selective antimicrobial profile, being specifically active against C. albicans (MIC of 500 μg mL−1). Additionally, the root extract (50 μg mL−1) showed the highest cell inhibition percentages against tumor cell lines MCF-7 (59.5%), HCT116 (49.2%), and HepG2 (61.0%). Forty-eight metabolites were annotated by GC–MS and 27 by LC–MS. These included alkaloids, carbohydrates, fatty acids, hydrocarbons, organic acids, phenolic compounds, and terpenes. Taken together, these results showed that P. anisum root extract is a promising source of bioactive compounds.engSpringer VerlagAntioxidanteAgentes antimicrobianosAntitumoralEtnofarmacologia ·MetabolômicaAntioxidant capacityAntimicrobial compoundsAntitumor activity ·Bioactive metabolitesEthnopharmacology ·MetabolomicsPiper anisum as a promising new source of bioactive metabolitesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42260/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBatista, Danilo Piper....pdfBatista, Danilo Piper....pdfapplication/pdf1184543https://www.arca.fiocruz.br/bitstream/icict/42260/2/Batista%2c%20Danilo%20Piper....pdf37434307534cd198d08ef00d9dffc278MD52TEXTBatista, Danilo Piper....pdf.txtBatista, Danilo Piper....pdf.txtExtracted texttext/plain53819https://www.arca.fiocruz.br/bitstream/icict/42260/3/Batista%2c%20Danilo%20Piper....pdf.txtcdb1ad66aa0d453d55aa6ff2a56c4fd4MD53icict/422602023-03-15 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| dc.title.pt_BR.fl_str_mv |
Piper anisum as a promising new source of bioactive metabolites |
| title |
Piper anisum as a promising new source of bioactive metabolites |
| spellingShingle |
Piper anisum as a promising new source of bioactive metabolites Batista, Danilo Antioxidante Agentes antimicrobianos Antitumoral Etnofarmacologia · Metabolômica Antioxidant capacity Antimicrobial compounds Antitumor activity · Bioactive metabolites Ethnopharmacology · Metabolomics |
| title_short |
Piper anisum as a promising new source of bioactive metabolites |
| title_full |
Piper anisum as a promising new source of bioactive metabolites |
| title_fullStr |
Piper anisum as a promising new source of bioactive metabolites |
| title_full_unstemmed |
Piper anisum as a promising new source of bioactive metabolites |
| title_sort |
Piper anisum as a promising new source of bioactive metabolites |
| author |
Batista, Danilo |
| author_facet |
Batista, Danilo Campos, Patrícia Silva, Valdenizia Rodrigues Santos, Luciano de S. Bezerra, Daniel Pereira Soares, Milena Botelho Pereira Colepicolo, Pio Villela, Leonardo Zambotti Pinto, Ernani Araújo, Floricea M Martins, Dirceu Fernandez, Luzimar G Ligterink, Wilco Canuto, Gisele A. B Cerqueira·, Martins Dias de Ribeiro, Paulo R |
| author_role |
author |
| author2 |
Campos, Patrícia Silva, Valdenizia Rodrigues Santos, Luciano de S. Bezerra, Daniel Pereira Soares, Milena Botelho Pereira Colepicolo, Pio Villela, Leonardo Zambotti Pinto, Ernani Araújo, Floricea M Martins, Dirceu Fernandez, Luzimar G Ligterink, Wilco Canuto, Gisele A. B Cerqueira·, Martins Dias de Ribeiro, Paulo R |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Batista, Danilo Campos, Patrícia Silva, Valdenizia Rodrigues Santos, Luciano de S. Bezerra, Daniel Pereira Soares, Milena Botelho Pereira Colepicolo, Pio Villela, Leonardo Zambotti Pinto, Ernani Araújo, Floricea M Martins, Dirceu Fernandez, Luzimar G Ligterink, Wilco Canuto, Gisele A. B Cerqueira·, Martins Dias de Ribeiro, Paulo R |
| dc.subject.other.pt_BR.fl_str_mv |
Antioxidante Agentes antimicrobianos Antitumoral Etnofarmacologia · Metabolômica |
| topic |
Antioxidante Agentes antimicrobianos Antitumoral Etnofarmacologia · Metabolômica Antioxidant capacity Antimicrobial compounds Antitumor activity · Bioactive metabolites Ethnopharmacology · Metabolomics |
| dc.subject.en.pt_BR.fl_str_mv |
Antioxidant capacity Antimicrobial compounds Antitumor activity · Bioactive metabolites Ethnopharmacology · Metabolomics |
| description |
Federal University of Bahia (Project no: 11301), FAPESB, CNPq and CAPES. |
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2020 |
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2020-07-15T12:54:07Z |
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2020-07-15T12:54:07Z |
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2020 |
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info:eu-repo/semantics/article |
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BATISTA, Danilo et al. Piper anisum as a promising new source of bioactive metabolites. Chemical Papers, v. 74, p. 1505–1515, 2020. |
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https://www.arca.fiocruz.br/handle/icict/42260 |
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0366-6352 |
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BATISTA, Danilo et al. Piper anisum as a promising new source of bioactive metabolites. Chemical Papers, v. 74, p. 1505–1515, 2020. 0366-6352 |
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