Antimalarial activity of physalins B, D, F, and G

Detalhes bibliográficos
Autor(a) principal: Sá, Matheus Santos de
Data de Publicação: 2011
Outros Autores: Menezes, Maria N. de, Krettli, Antoniana Ursini, Ribeiro, Ivone Maria, Tomassini, Therezinha Coelho Barbosa, Santos, Ricardo Ribeiro dos, Azevedo Junior, Walter Filgueira de, Soares, Milena Botelho Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7299
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
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spelling Sá, Matheus Santos deMenezes, Maria N. deKrettli, Antoniana UrsiniRibeiro, Ivone MariaTomassini, Therezinha Coelho BarbosaSantos, Ricardo Ribeiro dosAzevedo Junior, Walter Filgueira deSoares, Milena Botelho Pereira2014-02-07T17:36:59Z2014-02-07T17:36:59Z2011SÁ, M. S. et al. Antimalarial activity of physalins B, D, F, and G. Journal of Natural Products, v. 74, n. 10, p. 2269-2272, 2011.1520-6025https://www.arca.fiocruz.br/handle/icict/7299dx.doi.org/10.1021/np200260f |engAmerican Chemical Society and American Society of PharmacognosyAntimalarial activity of physalins B, D, F, and Ginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, Minas Gerais, BrasilFundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilPontificia Universidade Católica. LaBioQuest-Faculdade de Biociencias. Porto Alegre, RS, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilThe antimalarial activities of physalins B, D, F, and G (1−4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity ensemble approach (SEA) database predicted the antimalarial activity of each of these compounds, which were shown using an in vitro assay against Plasmodium falciparum. However, treatment of P. berghei-infected mice with 3 increased parasitemia levels and mortality, whereas treatment with 2 was protective, causing a parasitemia reduction and a delay in mortality in P. berghei-infected mice. The exacerbation of in vivo infection by treatment with 3 is probably due to its potent immunosuppressive activity, which is not evident for 2Antimaláricos/farmacologiaImunossupressores/farmacologiaPhysalis/químicaPlasmodium berghei/efeitos de drogasPlasmodium falciparum/efeitos de drogasSecoesteroides/farmacologiaAnimaisAntimaláricos/químicaAntimaláricos/isolamento & purificaçãoImunossupressores/químicaImunossupressores/isolamento & purificaçãoMalária/quimioterapiaCamundongosCamundongos Endogâmicos BALB CParasitemia/quimioterapiaSecoesteroides/químicaSecoesteroides/isolamento & purificaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSá, MS. Antimalarial activity. 2011; v.74, p. 2269.pdfSá, MS. Antimalarial activity. 2011; v.74, p. 2269.pdfapplication/pdf216193https://www.arca.fiocruz.br/bitstream/icict/7299/1/S%c3%a1%2c%20MS.%20Antimalarial%20activity.%202011%3b%20v.74%2c%20p.%202269.pdfbcfa0177023bdfdc5ea38bab4708ffc7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7299/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSá, MS. Antimalarial activity. 2011; v.74, p. 2269.pdf.txtSá, MS. Antimalarial activity. 2011; v.74, p. 2269.pdf.txtExtracted texttext/plain19635https://www.arca.fiocruz.br/bitstream/icict/7299/5/S%c3%a1%2c%20MS.%20Antimalarial%20activity.%202011%3b%20v.74%2c%20p.%202269.pdf.txt05e6f87a0c7f82bf57ecfe2916159c4cMD55THUMBNAILSá, MS. Antimalarial activity. 2011; v.74, p. 2269.pdf.jpgSá, MS. 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dc.title.pt_BR.fl_str_mv Antimalarial activity of physalins B, D, F, and G
title Antimalarial activity of physalins B, D, F, and G
spellingShingle Antimalarial activity of physalins B, D, F, and G
Sá, Matheus Santos de
Antimaláricos/farmacologia
Imunossupressores/farmacologia
Physalis/química
Plasmodium berghei/efeitos de drogas
Plasmodium falciparum/efeitos de drogas
Secoesteroides/farmacologia
Animais
Antimaláricos/química
Antimaláricos/isolamento & purificação
Imunossupressores/química
Imunossupressores/isolamento & purificação
Malária/quimioterapia
Camundongos
Camundongos Endogâmicos BALB C
Parasitemia/quimioterapia
Secoesteroides/química
Secoesteroides/isolamento & purificação
title_short Antimalarial activity of physalins B, D, F, and G
title_full Antimalarial activity of physalins B, D, F, and G
title_fullStr Antimalarial activity of physalins B, D, F, and G
title_full_unstemmed Antimalarial activity of physalins B, D, F, and G
title_sort Antimalarial activity of physalins B, D, F, and G
author Sá, Matheus Santos de
author_facet Sá, Matheus Santos de
Menezes, Maria N. de
Krettli, Antoniana Ursini
Ribeiro, Ivone Maria
Tomassini, Therezinha Coelho Barbosa
Santos, Ricardo Ribeiro dos
Azevedo Junior, Walter Filgueira de
Soares, Milena Botelho Pereira
author_role author
author2 Menezes, Maria N. de
Krettli, Antoniana Ursini
Ribeiro, Ivone Maria
Tomassini, Therezinha Coelho Barbosa
Santos, Ricardo Ribeiro dos
Azevedo Junior, Walter Filgueira de
Soares, Milena Botelho Pereira
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sá, Matheus Santos de
Menezes, Maria N. de
Krettli, Antoniana Ursini
Ribeiro, Ivone Maria
Tomassini, Therezinha Coelho Barbosa
Santos, Ricardo Ribeiro dos
Azevedo Junior, Walter Filgueira de
Soares, Milena Botelho Pereira
dc.subject.decs.pt_BR.fl_str_mv Antimaláricos/farmacologia
Imunossupressores/farmacologia
Physalis/química
Plasmodium berghei/efeitos de drogas
Plasmodium falciparum/efeitos de drogas
Secoesteroides/farmacologia
Animais
Antimaláricos/química
Antimaláricos/isolamento & purificação
Imunossupressores/química
Imunossupressores/isolamento & purificação
Malária/quimioterapia
Camundongos
Camundongos Endogâmicos BALB C
Parasitemia/quimioterapia
Secoesteroides/química
Secoesteroides/isolamento & purificação
topic Antimaláricos/farmacologia
Imunossupressores/farmacologia
Physalis/química
Plasmodium berghei/efeitos de drogas
Plasmodium falciparum/efeitos de drogas
Secoesteroides/farmacologia
Animais
Antimaláricos/química
Antimaláricos/isolamento & purificação
Imunossupressores/química
Imunossupressores/isolamento & purificação
Malária/quimioterapia
Camundongos
Camundongos Endogâmicos BALB C
Parasitemia/quimioterapia
Secoesteroides/química
Secoesteroides/isolamento & purificação
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-02-07T17:36:59Z
dc.date.available.fl_str_mv 2014-02-07T17:36:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SÁ, M. S. et al. Antimalarial activity of physalins B, D, F, and G. Journal of Natural Products, v. 74, n. 10, p. 2269-2272, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7299
dc.identifier.issn.none.fl_str_mv 1520-6025
dc.identifier.doi.none.fl_str_mv dx.doi.org/10.1021/np200260f |
identifier_str_mv SÁ, M. S. et al. Antimalarial activity of physalins B, D, F, and G. Journal of Natural Products, v. 74, n. 10, p. 2269-2272, 2011.
1520-6025
dx.doi.org/10.1021/np200260f |
url https://www.arca.fiocruz.br/handle/icict/7299
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv American Chemical Society and American Society of Pharmacognosy
publisher.none.fl_str_mv American Chemical Society and American Society of Pharmacognosy
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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