Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/27498 |
Resumo: | Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ. Brasil. |
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Possas, CristinaOliveira, Ricardo Lourenço deTauil, Pedro LuizPinheiro, Francisco de PaulaPissinatti, AlcidesCunha, Rivaldo Venâncio daFreire, MarcosMartins, Reinaldo MenezesHomma, Akira2018-07-12T12:09:39Z2018-07-12T12:09:39Z2018POSSAS, Cristina; et al. Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization. Mem Inst Oswaldo Cruz, E-pub: 7 Jun 2018.0074-0276https://www.arca.fiocruz.br/handle/icict/2749810.1590/0074-027601802781678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzFebre AmarelaVacinaFatores eco-sociaisImunização humanaImunização de macacosProdução de vacinasBrasilYellow feverVaccineeco-social factorshuman immunizationmonkey immunizationvaccine productionBrazilYellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunizationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Universidade de Brasília. Escola de Medicina. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ. Brasil.Instituto Estadual do Meio Ambiente. Centro de Primatologia do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ. Brasil.We discuss the complex eco-social factors involved in the puzzle of the unexpected rapid viral spread in the ongoing Brazilian yellow fever outbreak, which has increased the reurbanization risk of a disease without urban cases in the Americas since 1942. Indeed, this rapid spatial viral dissemination to the Southeast and South regions, now circulating in the Atlantic Forest fragments close to peri-urban areas of the main Brazilian megalopolises (São Paulo and Rio de Janeiro) has led to an exponential increase in the number of yellow fever cases. In less than 18 months, 1,833 confirmed cases and 578 deaths were recorded most of them reported in the Southeast region (99,9%). Large epizooties in monkeys and other non-human primates (NHPs) were communicated in the country with 732 YFV laboratory confirmed events only in the 2017/2018 monitoring period We also discuss the peculiarities and similarities of the current outbreak when compared with previous great epidemics, examining several hypotheses to explain the recent unexpected acceleration of epizootic waves in the sylvatic cycle of the YFV together with the role of human, NHPs and mosquito mobility with respect to viral spread. We conclude that the most feasible hypothesis to explain this rapidity would be related to human behavior combined with ecological changes that promoted a significant increase in mosquito and NHP densities and their contacts with humans. We emphasize the urgent need for an adequate response to this outbreak such as extending immunization coverage to the whole Brazilian population and developing novel strategies for immunization of NHPs confined in selected reserve areas and zoos. Finally, we stress the urgent need to improve the quality of response in order to prevent future outbreaks and a catastrophic reurbanization of the disease in Brazil and other South American countries. Continuous monitoring of YFV receptivity and vulnerability conditions with effective control of the urban vector Aedes aegypti and significant investments in YF vaccine production capacity and research and development for reduction of adverse effects are of the highest priority.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27498/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALricardo_oliveira2_etal_IOC_2018.pdfricardo_oliveira2_etal_IOC_2018.pdfapplication/pdf816094https://www.arca.fiocruz.br/bitstream/icict/27498/2/ricardo_oliveira2_etal_IOC_2018.pdfb73c8ccb7f882ed247000663b168210fMD52TEXTricardo_oliveira2_etal_IOC_2018.pdf.txtricardo_oliveira2_etal_IOC_2018.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization |
| title |
Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization |
| spellingShingle |
Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization Possas, Cristina Febre Amarela Vacina Fatores eco-sociais Imunização humana Imunização de macacos Produção de vacinas Brasil Yellow fever Vaccine eco-social factors human immunization monkey immunization vaccine production Brazil |
| title_short |
Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization |
| title_full |
Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization |
| title_fullStr |
Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization |
| title_full_unstemmed |
Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization |
| title_sort |
Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization |
| author |
Possas, Cristina |
| author_facet |
Possas, Cristina Oliveira, Ricardo Lourenço de Tauil, Pedro Luiz Pinheiro, Francisco de Paula Pissinatti, Alcides Cunha, Rivaldo Venâncio da Freire, Marcos Martins, Reinaldo Menezes Homma, Akira |
| author_role |
author |
| author2 |
Oliveira, Ricardo Lourenço de Tauil, Pedro Luiz Pinheiro, Francisco de Paula Pissinatti, Alcides Cunha, Rivaldo Venâncio da Freire, Marcos Martins, Reinaldo Menezes Homma, Akira |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Possas, Cristina Oliveira, Ricardo Lourenço de Tauil, Pedro Luiz Pinheiro, Francisco de Paula Pissinatti, Alcides Cunha, Rivaldo Venâncio da Freire, Marcos Martins, Reinaldo Menezes Homma, Akira |
| dc.subject.other.pt_BR.fl_str_mv |
Febre Amarela Vacina Fatores eco-sociais Imunização humana Imunização de macacos Produção de vacinas Brasil |
| topic |
Febre Amarela Vacina Fatores eco-sociais Imunização humana Imunização de macacos Produção de vacinas Brasil Yellow fever Vaccine eco-social factors human immunization monkey immunization vaccine production Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
Yellow fever Vaccine eco-social factors human immunization monkey immunization vaccine production Brazil |
| description |
Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ. Brasil. |
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2018 |
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2018-07-12T12:09:39Z |
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2018-07-12T12:09:39Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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POSSAS, Cristina; et al. Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization. Mem Inst Oswaldo Cruz, E-pub: 7 Jun 2018. |
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https://www.arca.fiocruz.br/handle/icict/27498 |
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0074-0276 |
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10.1590/0074-02760180278 |
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1678-8060 |
| identifier_str_mv |
POSSAS, Cristina; et al. Yellow fever outbreak in Brazil: the puzzle of rapid viral spread and challenges for immunization. Mem Inst Oswaldo Cruz, E-pub: 7 Jun 2018. 0074-0276 10.1590/0074-02760180278 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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