Active cytomegalovirus (CMV) infection in liver recipients in a high CMV seroprevalence region - outcomes and the use of antigenemia

Detalhes bibliográficos
Autor(a) principal: Cunha, André Gusmão
Data de Publicação: 2014
Outros Autores: Cunha, Andréa Mendonça Gusmão, Solla, Davi Jorge Fontoura, Chaves, Ricardo Z. T, Castro Filho, Bernardo Galvão, Nascimento, Roberto Meyer
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14815
Resumo: Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Hospital Português. Serviço de Transplante Hepático. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, Brasil
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spelling Cunha, André GusmãoCunha, Andréa Mendonça GusmãoSolla, Davi Jorge FontouraChaves, Ricardo Z. TCastro Filho, Bernardo GalvãoNascimento, Roberto Meyer2016-07-07T14:01:58Z2016-07-08T18:41:56Z2016-07-07T14:01:58Z2016-07-08T18:41:56Z2014CUNHA, A. G. et al. Active cytomegalovirus (CMV) infection in liver recipients in a high CMV seroprevalence region - outcomes and the use of antigenemia. Virus Reviews and Research, v. 18, p. 1-6, 2014.1519-2563https://www.arca.fiocruz.br/handle/icict/14815engSociedade Brasileira de VirologiaActive cytomegalovirus (CMV) infection in liver recipients in a high CMV seroprevalence region - outcomes and the use of antigenemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Hospital Português. Serviço de Transplante Hepático. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilCytomegalovirus (CMV) is the most frequent viral infection in liver recipients, acting as immunomodulatory factor for other opportunistic infections and rejection. We assessed the outcomes of CMV infection in liver recipients in a high CMV seroprevalence region and the use of antigenemia for the diagnosis of CMV syndrome. Between March 2007 and April 2009, 44 liver recipients collected 344 samples for CMV antigenemia. Defi nition of active CMV infections used literature criteria. Recipients’ outcomes [CMV syndrome, Hepatitis C Virus (HCV) recurrence, rejection and mortality] were analyzed. Performance of antigenemia for the diagnosis of CMV syndrome was assessed by the area under the Receiver Operating Curve (AUROC) of 52 positive samples, representing 24 recipients. CMV serology was positive (R+) in 90.9% of liver recipients. CMV syndrome occurred in 18 (40.9%) recipients. CMV negative serology (R-) recipients had lower disease-free time, as well as lower one-year and four-year survival rates (p = 0.022 and p = 0.004, respectively). HCV+ recipients presented CMV-associated indirect eff ects and had a tendency to lower fouryear survival rate (p=0.089). Th e AUROC for CMV syndrome was 0.745 (95% CI 0.606 to 0.856, p = 0.006), with a cut-off of more than 8 positive cells/200,000 leukocytes, (sensitivity of 88.9% and specifi city of 74.4%). CMV infection is associated to morbidity and lower survival rates in liver recipients in a high CMV seroprevalence region. Using antigenemia, the cut-off for diagnosing CMV syndrome was higher than 8 positive cells/200,000 leukocytes, with an appropriated performance through its accuracy.AntiviralCytomegalovirusCMVLiver transplantAntigenemiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTCunha AG Acite cytomegalovirus....pdf.txtCunha AG Acite cytomegalovirus....pdf.txtExtracted texttext/plain27390https://www.arca.fiocruz.br/bitstream/icict/14815/4/Cunha%20AG%20Acite%20cytomegalovirus....pdf.txt528b1cfbc9905e3076b796d4f5c6bdd9MD54ORIGINALCunha AG Acite cytomegalovirus....pdfapplication/pdf252273https://www.arca.fiocruz.br/bitstream/icict/14815/2/Cunha%20AG%20Acite%20cytomegalovirus....pdf4ba6029b7d2163dacc546d26dcf4dcb2MD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14815/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/148152023-03-15 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dc.title.pt_BR.fl_str_mv Active cytomegalovirus (CMV) infection in liver recipients in a high CMV seroprevalence region - outcomes and the use of antigenemia
title Active cytomegalovirus (CMV) infection in liver recipients in a high CMV seroprevalence region - outcomes and the use of antigenemia
spellingShingle Active cytomegalovirus (CMV) infection in liver recipients in a high CMV seroprevalence region - outcomes and the use of antigenemia
Cunha, André Gusmão
Antiviral
Cytomegalovirus
CMV
Liver transplant
Antigenemia
title_short Active cytomegalovirus (CMV) infection in liver recipients in a high CMV seroprevalence region - outcomes and the use of antigenemia
title_full Active cytomegalovirus (CMV) infection in liver recipients in a high CMV seroprevalence region - outcomes and the use of antigenemia
title_fullStr Active cytomegalovirus (CMV) infection in liver recipients in a high CMV seroprevalence region - outcomes and the use of antigenemia
title_full_unstemmed Active cytomegalovirus (CMV) infection in liver recipients in a high CMV seroprevalence region - outcomes and the use of antigenemia
title_sort Active cytomegalovirus (CMV) infection in liver recipients in a high CMV seroprevalence region - outcomes and the use of antigenemia
author Cunha, André Gusmão
author_facet Cunha, André Gusmão
Cunha, Andréa Mendonça Gusmão
Solla, Davi Jorge Fontoura
Chaves, Ricardo Z. T
Castro Filho, Bernardo Galvão
Nascimento, Roberto Meyer
author_role author
author2 Cunha, Andréa Mendonça Gusmão
Solla, Davi Jorge Fontoura
Chaves, Ricardo Z. T
Castro Filho, Bernardo Galvão
Nascimento, Roberto Meyer
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cunha, André Gusmão
Cunha, Andréa Mendonça Gusmão
Solla, Davi Jorge Fontoura
Chaves, Ricardo Z. T
Castro Filho, Bernardo Galvão
Nascimento, Roberto Meyer
dc.subject.en.pt_BR.fl_str_mv Antiviral
Cytomegalovirus
CMV
Liver transplant
Antigenemia
topic Antiviral
Cytomegalovirus
CMV
Liver transplant
Antigenemia
description Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Hospital Português. Serviço de Transplante Hepático. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, Brasil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2016-07-07T14:01:58Z
2016-07-08T18:41:56Z
dc.date.available.fl_str_mv 2016-07-07T14:01:58Z
2016-07-08T18:41:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CUNHA, A. G. et al. Active cytomegalovirus (CMV) infection in liver recipients in a high CMV seroprevalence region - outcomes and the use of antigenemia. Virus Reviews and Research, v. 18, p. 1-6, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14815
dc.identifier.issn.pt_BR.fl_str_mv 1519-2563
identifier_str_mv CUNHA, A. G. et al. Active cytomegalovirus (CMV) infection in liver recipients in a high CMV seroprevalence region - outcomes and the use of antigenemia. Virus Reviews and Research, v. 18, p. 1-6, 2014.
1519-2563
url https://www.arca.fiocruz.br/handle/icict/14815
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Virologia
publisher.none.fl_str_mv Sociedade Brasileira de Virologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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