IgA nephropathy in Brazil: apropos of 600 cases

Detalhes bibliográficos
Autor(a) principal: Soares, Maria Fernanda
Data de Publicação: 2015
Outros Autores: Caldas, Maria Lucia Ribeiro, dosSantos, Washington Luis Conrado, Sementilli, Angelo, Furtado, P, Araújo, Stanley, Pegas, K. L, Petterle, Ricardo Rasmussen, Franco, M. F
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14027
Resumo: Federal University of São Paulo (UNIFESP). Department of Pathology. São Paulo, SP, Brasil / Federal University of Paraná (UFPR). Department of Medical Pathology. Curitiba, PR, Brasil / Brazilian Kidney Club. Brazilian Society of Pathology (SBP). São Paulo, SP, Brasil / Departamento de Patologia Médica. Curitiba, PR, Brasil
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spelling Soares, Maria FernandaCaldas, Maria Lucia RibeirodosSantos, Washington Luis ConradoSementilli, AngeloFurtado, PAraújo, StanleyPegas, K. LPetterle, Ricardo RasmussenFranco, M. F2016-04-29T11:54:47Z2016-04-29T11:54:47Z2015SOARES, M. F. et al. IgA nephropathy in Brazil: apropos of 600 cases. Springerplus, v. 4, p. 547, 2015.2193-1801https://www.arca.fiocruz.br/handle/icict/1402710.1186/s40064-015-1323-xengSpringerOpenIgA nephropathy in Brazil: apropos of 600 casesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of São Paulo (UNIFESP). Department of Pathology. São Paulo, SP, Brasil / Federal University of Paraná (UFPR). Department of Medical Pathology. Curitiba, PR, Brasil / Brazilian Kidney Club. Brazilian Society of Pathology (SBP). São Paulo, SP, Brasil / Departamento de Patologia Médica. Curitiba, PR, BrasilFederal Fluminense University (UFF). Department of Pathology. Niterói, RJ, Brasil / Brazilian Kidney Club. Brazilian Society of Pathology (SBP). São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Brazilian Kidney Club. Brazilian Society of Pathology (SBP). São Paulo, SP, BrasilSantos Metropolitan University (UNIMES). / Ana Costa Hospital. Santos, SP, Brasil / Brazilian Kidney Club. Brazilian Society of Pathology (SBP). São Paulo, SP, BrasilFederal University of São Paulo (UNIFESP). Department of Pathology. São Paulo, SP, Brasil / Brazilian Kidney Club. Brazilian Society of Pathology (SBP). São Paulo, SP, BrasilFederal University of Minas Gerais (UFMG). Clinics Hospital. Belo Horizonte, BH, Brasil / Federal University of Ouro Preto (UFOP). Ouro Prêto, MG, BrasilSanta Casa de Misericórdia de Porto Alegre. Porto Alegre, RS, Brasil / Brazilian Kidney Club. Brazilian Society of Pathology (SBP). São Paulo, SP, BrasilFederal University of Parana (UFPR). Division of Health Sciences. Curitiba, PR, BrasilFederal University of São Paulo (UNIFESP). Department of Pathology. São Paulo, SP, Brasil / Brazilian Kidney Club. Brazilian Society of Pathology (SBP). São Paulo, SP, BrasilIgA nephropathy (IgAN) is the commonest primary glomerular disease worldwide. Studies on its prevalence in Brazil are however scarce. Databases and clinical records from 10 reference centres were retrospectively reviewed. Clinical and laboratory features at the moment of the biopsy were retrieved (age, gender, presence of hematuria, serum creatinine [mg/dL], proteinuria [g/24 h]). Renal biopsy findings were classified according to Haas single grade classification scheme and the Oxford Classification of IgAN. 600 cases of IgAN were identified, of which 568 (94.7 %) were on native kidneys. Male to female ratio was 1.24:1. Patients averaged 32.76 ± 15.12 years old (range 4–89, median 32). Proteinuria and hematuria were observed, respectively in 56.63 and 72.29 % of patients. The association of both these findings occurred in 37.95 % of the cases. Serum creatinine averaged 1.65 ± 0.67 mg/dL (median 1.5 mg/dL) at diagnosis. Segmental sclerosis and mesangial hypercellularity were the main glomerular findings (47.6 and 46.2 %) The commonest combination by Oxford Classification of IgAN, was M0 E0 S0 T0 (22.4 %). Chronic tubulo-interstitial lesions with an extension wider than 25 % of the renal cortex could be identified in 32.2 % of the cases. Tubular atrophy and interstitial fibrosis were more strongly associated with higher 24-h proteinuria and serum creatinine levels. Segmental sclerosis (S1) showed a stronger tendency of association with the presence of tubulo-interstitial lesions (T1 and T2) than other glomerular variables. To the best of our knowledge this is the largest series of IgAN in Brazil. It depicts the main biopsy findings and their possible clinical correlates. Our set of data is comparable to previous reports.IgA nephropathyBerger’s diseasePathologyEpidemiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14027/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSoares MF IgA nephropathy....pdfSoares MF IgA nephropathy....pdfapplication/pdf943029https://www.arca.fiocruz.br/bitstream/icict/14027/2/Soares%20MF%20IgA%20nephropathy....pdfa10b6a2034fd9e1bb6f6fdb6fe87ea8eMD52TEXTSoares MF IgA nephropathy....pdf.txtSoares MF IgA nephropathy....pdf.txtExtracted texttext/plain25177https://www.arca.fiocruz.br/bitstream/icict/14027/3/Soares%20MF%20IgA%20nephropathy....pdf.txtc9768551294b3feb926d609b69e5d5c6MD53icict/140272023-03-15 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dc.title.pt_BR.fl_str_mv IgA nephropathy in Brazil: apropos of 600 cases
title IgA nephropathy in Brazil: apropos of 600 cases
spellingShingle IgA nephropathy in Brazil: apropos of 600 cases
Soares, Maria Fernanda
IgA nephropathy
Berger’s disease
Pathology
Epidemiology
title_short IgA nephropathy in Brazil: apropos of 600 cases
title_full IgA nephropathy in Brazil: apropos of 600 cases
title_fullStr IgA nephropathy in Brazil: apropos of 600 cases
title_full_unstemmed IgA nephropathy in Brazil: apropos of 600 cases
title_sort IgA nephropathy in Brazil: apropos of 600 cases
author Soares, Maria Fernanda
author_facet Soares, Maria Fernanda
Caldas, Maria Lucia Ribeiro
dosSantos, Washington Luis Conrado
Sementilli, Angelo
Furtado, P
Araújo, Stanley
Pegas, K. L
Petterle, Ricardo Rasmussen
Franco, M. F
author_role author
author2 Caldas, Maria Lucia Ribeiro
dosSantos, Washington Luis Conrado
Sementilli, Angelo
Furtado, P
Araújo, Stanley
Pegas, K. L
Petterle, Ricardo Rasmussen
Franco, M. F
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Soares, Maria Fernanda
Caldas, Maria Lucia Ribeiro
dosSantos, Washington Luis Conrado
Sementilli, Angelo
Furtado, P
Araújo, Stanley
Pegas, K. L
Petterle, Ricardo Rasmussen
Franco, M. F
dc.subject.en.pt_BR.fl_str_mv IgA nephropathy
Berger’s disease
Pathology
Epidemiology
topic IgA nephropathy
Berger’s disease
Pathology
Epidemiology
description Federal University of São Paulo (UNIFESP). Department of Pathology. São Paulo, SP, Brasil / Federal University of Paraná (UFPR). Department of Medical Pathology. Curitiba, PR, Brasil / Brazilian Kidney Club. Brazilian Society of Pathology (SBP). São Paulo, SP, Brasil / Departamento de Patologia Médica. Curitiba, PR, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-04-29T11:54:47Z
dc.date.available.fl_str_mv 2016-04-29T11:54:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, M. F. et al. IgA nephropathy in Brazil: apropos of 600 cases. Springerplus, v. 4, p. 547, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14027
dc.identifier.issn.none.fl_str_mv 2193-1801
dc.identifier.doi.none.fl_str_mv 10.1186/s40064-015-1323-x
identifier_str_mv SOARES, M. F. et al. IgA nephropathy in Brazil: apropos of 600 cases. Springerplus, v. 4, p. 547, 2015.
2193-1801
10.1186/s40064-015-1323-x
url https://www.arca.fiocruz.br/handle/icict/14027
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SpringerOpen
publisher.none.fl_str_mv SpringerOpen
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/14027/2/Soares%20MF%20IgA%20nephropathy....pdf
https://www.arca.fiocruz.br/bitstream/icict/14027/3/Soares%20MF%20IgA%20nephropathy....pdf.txt
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