The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance

Detalhes bibliográficos
Autor(a) principal: Passos, Geraldo Aleixo
Data de Publicação: 2015
Outros Autores: Cruz, Daniella Arêas Mendes da, Oliveira, Emma Hérida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14392
Resumo: Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Genética. Grupo de Imunogenética Molecular. Ribeirão Preto, SP, Brasil / Universidade de São Paulo. Escola de Odontologia de Ribeirão Preto. Departamento de Morfologia, Fisiologia e Patologia Básica. Disciplinas de Genética e Biologia Molecular. Ribeirão Preto, SP, Brasil.
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spelling Passos, Geraldo AleixoCruz, Daniella Arêas Mendes daOliveira, Emma Hérida2016-05-19T14:08:30Z2016-05-19T14:08:30Z2015PASSOS, Geraldo Aleixo; CRUZ, Daniella Arêas Mendes da; OLIVEIRA, Emma Hérida. The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance. Frontiers in Immunology, v.6, Article 352, 7p, July 2015.1664-3224https://www.arca.fiocruz.br/handle/icict/1439210.3389/fimmu.2015.00352engFrontiers MediaThe thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central toleranceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Genética. Grupo de Imunogenética Molecular. Ribeirão Preto, SP, Brasil / Universidade de São Paulo. Escola de Odontologia de Ribeirão Preto. Departamento de Morfologia, Fisiologia e Patologia Básica. Disciplinas de Genética e Biologia Molecular. Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Genética. Grupo de Imunogenética Molecular. Ribeirão Preto, SP, Brasil.Developing thymocytes interact sequentially with two distinct structures within the thymus: the cortex and medulla. Surviving single-positive and double-positive thymocytes from the cortex migrate into the medulla, where they interact with medullary thymic epithelial cells (mTECs). These cells ectopically express a vast set of peripheral tissue antigens (PTAs), a property termed promiscuous gene expression that is associated with the presentation of PTAs by mTECs to thymocytes. Thymocyte clones that have a high affinity for PTAs are eliminated by apoptosis in a process termed negative selection, which is essential for tolerance induction. The Aire gene is an important factor that controls the expression of a large set of PTAs. In addition to PTAs, Aire also controls the expression of miRNAs in mTECs. These miRNAs are important in the organization of the thymic architecture and act as posttranscriptional controllers of PTAs. Herein, we discuss recent discoveries and highlight open questions regarding the migration and interaction of developing thymocytes with thymic stroma, the ectopic expression of PTAs by mTECs, the association between Aire and miRNAs and its effects on central tolerance.AIREmIRNAMTECThymus glandThymocitesCell adhesionPromiscuous gene expressionCentral toleranceMicroRNAsTimoAdesão CelularTolerância Centralinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14392/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALdaniela2_cruz_etal_IOC_2015.pdfdaniela2_cruz_etal_IOC_2015.pdfapplication/pdf1729001https://www.arca.fiocruz.br/bitstream/icict/14392/2/daniela2_cruz_etal_IOC_2015.pdf14b517d3e4d90e6421407ef396328d42MD52TEXTdaniela2_cruz_etal_IOC_2015.pdf.txtdaniela2_cruz_etal_IOC_2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance
title The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance
spellingShingle The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance
Passos, Geraldo Aleixo
AIRE
mIRNA
MTEC
Thymus gland
Thymocites
Cell adhesion
Promiscuous gene expression
Central tolerance
MicroRNAs
Timo
Adesão Celular
Tolerância Central
title_short The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance
title_full The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance
title_fullStr The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance
title_full_unstemmed The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance
title_sort The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance
author Passos, Geraldo Aleixo
author_facet Passos, Geraldo Aleixo
Cruz, Daniella Arêas Mendes da
Oliveira, Emma Hérida
author_role author
author2 Cruz, Daniella Arêas Mendes da
Oliveira, Emma Hérida
author2_role author
author
dc.contributor.author.fl_str_mv Passos, Geraldo Aleixo
Cruz, Daniella Arêas Mendes da
Oliveira, Emma Hérida
dc.subject.en.pt_BR.fl_str_mv AIRE
mIRNA
MTEC
Thymus gland
Thymocites
Cell adhesion
Promiscuous gene expression
Central tolerance
topic AIRE
mIRNA
MTEC
Thymus gland
Thymocites
Cell adhesion
Promiscuous gene expression
Central tolerance
MicroRNAs
Timo
Adesão Celular
Tolerância Central
dc.subject.decs.pt_BR.fl_str_mv MicroRNAs
Timo
Adesão Celular
Tolerância Central
description Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Genética. Grupo de Imunogenética Molecular. Ribeirão Preto, SP, Brasil / Universidade de São Paulo. Escola de Odontologia de Ribeirão Preto. Departamento de Morfologia, Fisiologia e Patologia Básica. Disciplinas de Genética e Biologia Molecular. Ribeirão Preto, SP, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-05-19T14:08:30Z
dc.date.available.fl_str_mv 2016-05-19T14:08:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PASSOS, Geraldo Aleixo; CRUZ, Daniella Arêas Mendes da; OLIVEIRA, Emma Hérida. The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance. Frontiers in Immunology, v.6, Article 352, 7p, July 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14392
dc.identifier.issn.none.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2015.00352
identifier_str_mv PASSOS, Geraldo Aleixo; CRUZ, Daniella Arêas Mendes da; OLIVEIRA, Emma Hérida. The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance. Frontiers in Immunology, v.6, Article 352, 7p, July 2015.
1664-3224
10.3389/fimmu.2015.00352
url https://www.arca.fiocruz.br/handle/icict/14392
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/14392/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/14392/2/daniela2_cruz_etal_IOC_2015.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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