Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance

Detalhes bibliográficos
Autor(a) principal: Vieira, Thiago de Souza
Data de Publicação: 2020
Outros Autores: Iniguez, Eva, Castro, Waldione de, Karmakar, Subir, Disotuar, Maria M., Cecilio, Pedro, Lacsina, Joshua R., Meneses, Claudio, Nagata, Bianca M., Cardoso, Silvia, Sonenshine, Daniel E., Moore, Ian N., Borges, Valeria de Matos, Dey, Ranadhir, Soares, Miguel P., Nakhasi, Hira L., Oliveira, Fabiano, Valenzuela, Jesus G., Kamhawi, Shaden
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44586
Resumo: We thank Ana Beatriz F. Barletta (LMVR, National Institute of Allergy and Infectious Diseases [NIAID]), Owen M. Schwartz, and Margery Smelkinson (Biological Imaging Facility, Research Technology Branch, NIAID) for their support with the confocal microscope and Lucas Tirloni (LMVR, NIAID) for his insights into tick biology. The graphical abstract is courtesy of Visual Medical Arts, NIAID, Rocky Mountain Labs; the illustration is by Ryan Kissinger. This research was supported by the Intramural Research Program of the NIH, NIAID. The findings of this study are an informal communication and represent
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spelling Vieira, Thiago de SouzaIniguez, EvaCastro, Waldione deKarmakar, SubirDisotuar, Maria M.Cecilio, PedroLacsina, Joshua R.Meneses, ClaudioNagata, Bianca M.Cardoso, SilviaSonenshine, Daniel E.Moore, Ian N.Borges, Valeria de MatosDey, RanadhirSoares, Miguel P.Nakhasi, Hira L.Oliveira, FabianoValenzuela, Jesus G.Kamhawi, Shaden2020-11-23T14:15:33Z2020-11-23T14:15:33Z2020VIEIRA, Thiago de Souza et al. Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance. Cell Reports, p. 1-18, Oct. 27 2020.2211-1247https://www.arca.fiocruz.br/handle/icict/4458610.1016/j.celrep.2020.108317We thank Ana Beatriz F. Barletta (LMVR, National Institute of Allergy and Infectious Diseases [NIAID]), Owen M. Schwartz, and Margery Smelkinson (Biological Imaging Facility, Research Technology Branch, NIAID) for their support with the confocal microscope and Lucas Tirloni (LMVR, NIAID) for his insights into tick biology. The graphical abstract is courtesy of Visual Medical Arts, NIAID, Rocky Mountain Labs; the illustration is by Ryan Kissinger. This research was supported by the Intramural Research Program of the NIH, NIAID. The findings of this study are an informal communication and representNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.Center for Biologics Evaluation and Research. Food and Drug Administration. Laboratory of Emerging Pathogens. Division of Emerging and Transfusion Transmitted Diseases. Silver Spring, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Infectious Disease Pathogenesis Section, Comparative Medicine Branch. Rockville, MD, USA.Instituto Gulbenkian de Ciência. Oeiras, Lisboa, Portugal.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Infectious Disease Pathogenesis Section. Comparative Medicine Branch. Rockville, MD, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Center for Biologics Evaluation and Research. Food and Drug Administration. Laboratory of Emerging Pathogens. Division of Emerging and Transfusion Transmitted Diseases. Silver Spring, MD, USAInstituto Gulbenkian de Ciência. Oeiras, Lisboa, Portugal.Center for Biologics Evaluation and Research. Food and Drug Administration. Laboratory of Emerging Pathogens. Division of Emerging and Transfusion Transmitted Diseases. Silver Spring, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Vector Molecular Biology Section, Laboratory of Malaria and Vector Research. Rockville, MD, USA.Hematophagous vectors lacerate host skin and capillaries to acquire a blood meal, resulting in leakage of red blood cells (RBCs) and inflammation. Here, we show that heme oxygenase-1 (HO-1), a pleiotropic cytoprotective isoenzyme that mitigates heme-mediated tissue damage, is induced after bites of sand flies, mosquitoes, and ticks. Further, we demonstrate that erythrophagocytosis by macrophages, including a skinresiding CD163+CD91+ professional iron-recycling subpopulation, produces HO-1 after bites. Importantly, we establish that global deletion or transient inhibition of HO-1 in mice increases inflammation and pathology following Leishmania-infected sand fly bites without affecting parasite number, whereas CO, an end product of the HO-1 enzymatic reaction, suppresses skin inflammation. This indicates that HO-1 induction by bloodfeeding sand flies promotes tolerance to Leishmania infection. Collectively, our data demonstrate that HO-1 induction through erythrophagocytosis is a universal mechanism that regulates skin inflammation following blood feeding by arthropods, thus promoting early-stage disease tolerance to vector-borne pathogens.engCell PressHeme oxigenaseInflamaçãoPeleLeishmaniaHeme oxigenaesInflammationSkinLeishmaniaHeme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Toleranceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/44586/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALVieira, Thiago Sousa Heme Oxigenase....pdfVieira, Thiago Sousa Heme 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dc.title.pt_BR.fl_str_mv Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance
title Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance
spellingShingle Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance
Vieira, Thiago de Souza
Heme oxigenase
Inflamação
Pele
Leishmania
Heme oxigenaes
Inflammation
Skin
Leishmania
title_short Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance
title_full Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance
title_fullStr Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance
title_full_unstemmed Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance
title_sort Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance
author Vieira, Thiago de Souza
author_facet Vieira, Thiago de Souza
Iniguez, Eva
Castro, Waldione de
Karmakar, Subir
Disotuar, Maria M.
Cecilio, Pedro
Lacsina, Joshua R.
Meneses, Claudio
Nagata, Bianca M.
Cardoso, Silvia
Sonenshine, Daniel E.
Moore, Ian N.
Borges, Valeria de Matos
Dey, Ranadhir
Soares, Miguel P.
Nakhasi, Hira L.
Oliveira, Fabiano
Valenzuela, Jesus G.
Kamhawi, Shaden
author_role author
author2 Iniguez, Eva
Castro, Waldione de
Karmakar, Subir
Disotuar, Maria M.
Cecilio, Pedro
Lacsina, Joshua R.
Meneses, Claudio
Nagata, Bianca M.
Cardoso, Silvia
Sonenshine, Daniel E.
Moore, Ian N.
Borges, Valeria de Matos
Dey, Ranadhir
Soares, Miguel P.
Nakhasi, Hira L.
Oliveira, Fabiano
Valenzuela, Jesus G.
Kamhawi, Shaden
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vieira, Thiago de Souza
Iniguez, Eva
Castro, Waldione de
Karmakar, Subir
Disotuar, Maria M.
Cecilio, Pedro
Lacsina, Joshua R.
Meneses, Claudio
Nagata, Bianca M.
Cardoso, Silvia
Sonenshine, Daniel E.
Moore, Ian N.
Borges, Valeria de Matos
Dey, Ranadhir
Soares, Miguel P.
Nakhasi, Hira L.
Oliveira, Fabiano
Valenzuela, Jesus G.
Kamhawi, Shaden
dc.subject.other.pt_BR.fl_str_mv Heme oxigenase
Inflamação
Pele
Leishmania
topic Heme oxigenase
Inflamação
Pele
Leishmania
Heme oxigenaes
Inflammation
Skin
Leishmania
dc.subject.en.pt_BR.fl_str_mv Heme oxigenaes
Inflammation
Skin
Leishmania
description We thank Ana Beatriz F. Barletta (LMVR, National Institute of Allergy and Infectious Diseases [NIAID]), Owen M. Schwartz, and Margery Smelkinson (Biological Imaging Facility, Research Technology Branch, NIAID) for their support with the confocal microscope and Lucas Tirloni (LMVR, NIAID) for his insights into tick biology. The graphical abstract is courtesy of Visual Medical Arts, NIAID, Rocky Mountain Labs; the illustration is by Ryan Kissinger. This research was supported by the Intramural Research Program of the NIH, NIAID. The findings of this study are an informal communication and represent
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-11-23T14:15:33Z
dc.date.available.fl_str_mv 2020-11-23T14:15:33Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VIEIRA, Thiago de Souza et al. Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance. Cell Reports, p. 1-18, Oct. 27 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44586
dc.identifier.issn.pt_BR.fl_str_mv 2211-1247
dc.identifier.doi.none.fl_str_mv 10.1016/j.celrep.2020.108317
identifier_str_mv VIEIRA, Thiago de Souza et al. Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance. Cell Reports, p. 1-18, Oct. 27 2020.
2211-1247
10.1016/j.celrep.2020.108317
url https://www.arca.fiocruz.br/handle/icict/44586
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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