Amicus or adversary: platelets in lung biology, acute injury, and inflammation

Detalhes bibliográficos
Autor(a) principal: Bozza, Fernando A.
Data de Publicação: 2009
Outros Autores: Shah, Amrapali M., Weyrich, Andrew S., Zimmerman, Guy A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/38788
Resumo: 2020-12-23
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spelling Bozza, Fernando A.Shah, Amrapali M.Weyrich, Andrew S.Zimmerman, Guy A.2019-12-23T12:52:07Z2019-12-23T12:52:07Z2009BOZZA, Fernando A. et al. Amicus or adversary: platelets in lung biology, acute Injury, and inflammation. American Journal of Respiratory Cell and Molecular Biology, v. 40, p. 123-134, 2009.1044-1549https://www.arca.fiocruz.br/handle/icict/3878810.1165/rcmb.2008-0241TR1535-4989engAmerican Thoracic SocietyAmicus or adversary: platelets in lung biology, acute injury, and inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-12-23Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / University of Utah. Program in Human Molecular Biology and Genetics. Salt Lake City, UT, USA.University of Utah. Department of Internal Medicine. Division of Respiratory and Critical Care Medicine. Salt Lake City, UT, USA / University of Utah. Program in Human Molecular Biology and Genetics. Salt Lake City, UT, USA.University of Utah. Department of Internal Medicine. Division of Respiratory and Critical Care Medicine. Salt Lake City, UT, USA / University of Utah. Program in Human Molecular Biology and Genetics. Salt Lake City, UT, USA.University of Utah. Department of Internal Medicine. Division of Respiratory and Critical Care Medicine. Salt Lake City, UT, USA / University of Utah. Program in Human Molecular Biology and Genetics. Salt Lake City, UT, USA.Platelets are the chief effector cells in hemostasis and have additional major functions in inflammation, vascular integrity, and tissue repair. Platelets and the lungs have interrelated activities. Previous studies provide evidence that platelets contribute to pulmonary vascular barrier function and are required for defense against pulmonary hemorrhage, and that the lungs can influence platelet number and distribution. There is also evidence that platelets contribute to pathologic syndromes of pulmonary inflammation and thrombosis. Thus, platelets have an ‘‘amicus or adversary’’ relationship with the lung. Recent observations and discoveries have established new paradigms relevant to influences of platelets on lung cell andmolecular biology. These new findings are in a variety of areas including thrombopoieis, nontraditional activities of platelets, new synthetic capabilities and mechanisms of post-translational gene expression, interactions of platelets with endothelial cells and contributions to alveolar capillary barrier permeability, interactions of platelets with myeloid leukocytes, and platelet involvement in stem cell signaling and vascular repair. These issues are considered in a translational approach, with an emphasis on acute lung injury and the acute respiratory distress syndrome.PlateletsInflammationThrombosisLung injuryinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/38788/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Bozza_Fernando_etal_INI_2009.pdfve_Bozza_Fernando_etal_INI_2009.pdfapplication/pdf944475https://www.arca.fiocruz.br/bitstream/icict/38788/2/ve_Bozza_Fernando_etal_INI_2009.pdf035aa1dd765464edc0be0f376559226aMD52TEXTve_Bozza_Fernando_etal_INI_2009.pdf.txtve_Bozza_Fernando_etal_INI_2009.pdf.txtExtracted texttext/plain83604https://www.arca.fiocruz.br/bitstream/icict/38788/3/ve_Bozza_Fernando_etal_INI_2009.pdf.txt3bf649825d70fb8a418a9d8cc006a96bMD53icict/387882021-03-24 16:32:40.862oai:www.arca.fiocruz.br:icict/38788Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:40Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Amicus or adversary: platelets in lung biology, acute injury, and inflammation
title Amicus or adversary: platelets in lung biology, acute injury, and inflammation
spellingShingle Amicus or adversary: platelets in lung biology, acute injury, and inflammation
Bozza, Fernando A.
Platelets
Inflammation
Thrombosis
Lung injury
title_short Amicus or adversary: platelets in lung biology, acute injury, and inflammation
title_full Amicus or adversary: platelets in lung biology, acute injury, and inflammation
title_fullStr Amicus or adversary: platelets in lung biology, acute injury, and inflammation
title_full_unstemmed Amicus or adversary: platelets in lung biology, acute injury, and inflammation
title_sort Amicus or adversary: platelets in lung biology, acute injury, and inflammation
author Bozza, Fernando A.
author_facet Bozza, Fernando A.
Shah, Amrapali M.
Weyrich, Andrew S.
Zimmerman, Guy A.
author_role author
author2 Shah, Amrapali M.
Weyrich, Andrew S.
Zimmerman, Guy A.
author2_role author
author
author
dc.contributor.author.fl_str_mv Bozza, Fernando A.
Shah, Amrapali M.
Weyrich, Andrew S.
Zimmerman, Guy A.
dc.subject.en.pt_BR.fl_str_mv Platelets
Inflammation
Thrombosis
Lung injury
topic Platelets
Inflammation
Thrombosis
Lung injury
description 2020-12-23
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2019-12-23T12:52:07Z
dc.date.available.fl_str_mv 2019-12-23T12:52:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BOZZA, Fernando A. et al. Amicus or adversary: platelets in lung biology, acute Injury, and inflammation. American Journal of Respiratory Cell and Molecular Biology, v. 40, p. 123-134, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/38788
dc.identifier.issn.pt_BR.fl_str_mv 1044-1549
dc.identifier.doi.none.fl_str_mv 10.1165/rcmb.2008-0241TR
dc.identifier.eissn.none.fl_str_mv 1535-4989
identifier_str_mv BOZZA, Fernando A. et al. Amicus or adversary: platelets in lung biology, acute Injury, and inflammation. American Journal of Respiratory Cell and Molecular Biology, v. 40, p. 123-134, 2009.
1044-1549
10.1165/rcmb.2008-0241TR
1535-4989
url https://www.arca.fiocruz.br/handle/icict/38788
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Thoracic Society
publisher.none.fl_str_mv American Thoracic Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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