Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30115 |
Resumo: | 2020-01-01 |
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Machado, Marina Amaral de AvilaBarbosa, Mariana MichelAlmeida, Alessandra MacielAraujo, Vania Eloisa deKakehasi, Adriana MariaAndrade, Eli Iola GurgelCherchiglia, Mariangela LealAcurcio, Francisco de Assis2018-11-20T17:08:24Z2018-11-20T17:08:24Z2013MACHADO, Marina Amaral de Avila et al. Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis. Rheumatol Int., v. 33, n. 9, p. 2199-213, 20130172-8172https://www.arca.fiocruz.br/handle/icict/3011510.1007/s00296-013-2772-6engSpringer InternationalEspondilite anquilosanteBloqueadores de TNFRevisão sistemáticaMeta-análiseAnkylosing spondylitisTNF blockersSystematic reviewMeta-analysisTreatment of ankylosing spondylitis with TNF blockers: a meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, BrazilFaculdade de Ciências Médicas. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilBiological agents directed against tumor necrosis factor (TNF) represent therapeutic options for patients with ankylosing spondylitis with high disease activity despite use of non-steroidal anti-inflammatory drugs. To evaluate the efficacy and safety of the anti-TNF agents infliximab, etanercept, adalimumab, golimumab, and certolizumab for the treatment of ankylosing spondylitis, we performed a systematic review of randomized clinical trials on adult patients with ankylosing spondylitis using articles culled from the EMBASE, MEDLINE, Cochrane Controlled Trials Register and LILACS databases (September/2012), manual literature search, and the gray literature. Study selections and data collection were performed by two independent reviewers, with disagreements solved by a third reviewer. The following outcomes were evaluated: ASAS 20 response, disease activity, physical function, vertebral mobility, adverse events, and withdraws. The meta-analysis was performed using the Review Manager(®) 5.1 software by applying the random effects model. Eighteen studies were included in this review. No study of certolizumab was included. Patients treated with anti-TNF agents were more likely to display an ASAS 20 response after 12/14 weeks (RR 2.21; 95 % CI 1.91; 2.56) and 24 weeks (RR 2.68; 95 % CI 2.06; 3.48) compared with controls, which was also true for several other efficacy outcomes. Meta-analysis of safety outcomes and withdraws did not indicate statistically significant differences between treatment and control groups after 12 or 30 weeks. Adalimumab, infliximab, etanercept, and golimumab can effectively reduce the signs and symptoms of the axial component of ankylosing spondylitis. Safety outcomes deserve further study, especially with respect to long-term follow-ups.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/30115/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALTreatment of ankylosing .pdfTreatment of ankylosing .pdfapplication/pdf1256965https://www.arca.fiocruz.br/bitstream/icict/30115/2/Treatment%20of%20ankylosing%20.pdf954ff7a39d1a7b1a1ae27ec633032821MD52TEXTTreatment of ankylosing .pdf.txtTreatment of ankylosing .pdf.txtExtracted texttext/plain57684https://www.arca.fiocruz.br/bitstream/icict/30115/3/Treatment%20of%20ankylosing%20.pdf.txta2974e089ba3f1874ef81be4da394c8aMD53icict/301152021-03-24 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dc.title.pt_BR.fl_str_mv |
Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis |
title |
Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis |
spellingShingle |
Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis Machado, Marina Amaral de Avila Espondilite anquilosante Bloqueadores de TNF Revisão sistemática Meta-análise Ankylosing spondylitis TNF blockers Systematic review Meta-analysis |
title_short |
Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis |
title_full |
Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis |
title_fullStr |
Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis |
title_full_unstemmed |
Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis |
title_sort |
Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis |
author |
Machado, Marina Amaral de Avila |
author_facet |
Machado, Marina Amaral de Avila Barbosa, Mariana Michel Almeida, Alessandra Maciel Araujo, Vania Eloisa de Kakehasi, Adriana Maria Andrade, Eli Iola Gurgel Cherchiglia, Mariangela Leal Acurcio, Francisco de Assis |
author_role |
author |
author2 |
Barbosa, Mariana Michel Almeida, Alessandra Maciel Araujo, Vania Eloisa de Kakehasi, Adriana Maria Andrade, Eli Iola Gurgel Cherchiglia, Mariangela Leal Acurcio, Francisco de Assis |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Machado, Marina Amaral de Avila Barbosa, Mariana Michel Almeida, Alessandra Maciel Araujo, Vania Eloisa de Kakehasi, Adriana Maria Andrade, Eli Iola Gurgel Cherchiglia, Mariangela Leal Acurcio, Francisco de Assis |
dc.subject.other.pt_BR.fl_str_mv |
Espondilite anquilosante Bloqueadores de TNF Revisão sistemática Meta-análise |
topic |
Espondilite anquilosante Bloqueadores de TNF Revisão sistemática Meta-análise Ankylosing spondylitis TNF blockers Systematic review Meta-analysis |
dc.subject.en.pt_BR.fl_str_mv |
Ankylosing spondylitis TNF blockers Systematic review Meta-analysis |
description |
2020-01-01 |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2018-11-20T17:08:24Z |
dc.date.available.fl_str_mv |
2018-11-20T17:08:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MACHADO, Marina Amaral de Avila et al. Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis. Rheumatol Int., v. 33, n. 9, p. 2199-213, 2013 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/30115 |
dc.identifier.issn.pt_BR.fl_str_mv |
0172-8172 |
dc.identifier.doi.none.fl_str_mv |
10.1007/s00296-013-2772-6 |
identifier_str_mv |
MACHADO, Marina Amaral de Avila et al. Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis. Rheumatol Int., v. 33, n. 9, p. 2199-213, 2013 0172-8172 10.1007/s00296-013-2772-6 |
url |
https://www.arca.fiocruz.br/handle/icict/30115 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Springer International |
publisher.none.fl_str_mv |
Springer International |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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