Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy

Detalhes bibliográficos
Autor(a) principal: Benvenuto, Domenico
Data de Publicação: 2020
Outros Autores: Angeletti, Silvia, Giovanetti, Marta, Bianchi, Marina, Pascarella, Stefano, Cauda, Roberto, Ciccozzi, Massimo, Cassone, Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40756
Resumo: Devido a pandemia mundial do COVID-19, o artigo da revista foi liberado em acesso aberto durante o ano de 2020, visando divulgação e disseminação.
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spelling Benvenuto, DomenicoAngeletti, SilviaGiovanetti, MartaBianchi, MarinaPascarella, StefanoCauda, RobertoCiccozzi, MassimoCassone, Antonio2020-04-14T19:13:38Z2020-04-14T19:13:38Z2020BENVENUTO, Domenico et al. Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy. Journal of Infection, p. 1-10, Mar. 2020.0163-4453https://www.arca.fiocruz.br/handle/icict/4075610.1016/j.jinf.2020.03.058Devido a pandemia mundial do COVID-19, o artigo da revista foi liberado em acesso aberto durante o ano de 2020, visando divulgação e disseminação.University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.University Campus Bio-Medico of Rome. Unit of Clinical Laboratory Science. Rome, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.University of Rome “La Sapienza”. "A. Rossi Fanelli". Department of Biochemical Sciences. Rome, Italy.University of Rome “La Sapienza”. "A. Rossi Fanelli". Department of Biochemical Sciences. Rome, Italy.UOC Malattie Infettive – Fondazione Policlinico Universitario “A.Gemelli” IRCCS. Rome, Italy / Catholic University of Sacred Heart. Department of Healthcare Surveillance and Bioethics. Rome Italy.University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.University of Siena. Center of genomics, genetics and biology. Siena, Italy.Background: SARS-CoV-2 is a new coronavirus that has spread globally, infecting more than 150000 people, and being declared pandemic by the WHO. We provide here bio-informatic, evolutionary analysis of 351 available sequences of its genome with the aim of mapping genome structural variations and the patterns of selection. Methods: A Maximum likelihood tree has been built and selective pressure has been investigated in order to find any mutation developed during the SARS-CoV-2 epidemic that could potentially affect clinical evolution of the infection. Finding: We have found in more recent isolates the presence of two mutations affecting the Non-Structural Protein 6 (NSP6) and the Open Reding Frame10 (ORF 10) adjacent regions. Amino acidic change stability analysis suggests both mutations could confer lower stability of the protein structures. Interpretation One of the two mutations, likely developed within the genome during virus spread, could affect virus intracellular survival. Genome follow-up of SARS-CoV-2 spread is urgently needed in order to identify mutations that could significantly modify virus pathogenicity. Funding: No specific funding source has been received.engElsevierSARS-CoV-2Análise evolutivaProteína não estrutural 6Autofagia viralCOVID-19CoronavírusSARS-CoV-2Evolutionary analysisNon-Structural Protein 6Viral autophagyCOVID-19CoronavirusEvolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy
title Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy
spellingShingle Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy
Benvenuto, Domenico
SARS-CoV-2
Análise evolutiva
Proteína não estrutural 6
Autofagia viral
COVID-19
Coronavírus
SARS-CoV-2
Evolutionary analysis
Non-Structural Protein 6
Viral autophagy
COVID-19
Coronavirus
title_short Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy
title_full Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy
title_fullStr Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy
title_full_unstemmed Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy
title_sort Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy
author Benvenuto, Domenico
author_facet Benvenuto, Domenico
Angeletti, Silvia
Giovanetti, Marta
Bianchi, Marina
Pascarella, Stefano
Cauda, Roberto
Ciccozzi, Massimo
Cassone, Antonio
author_role author
author2 Angeletti, Silvia
Giovanetti, Marta
Bianchi, Marina
Pascarella, Stefano
Cauda, Roberto
Ciccozzi, Massimo
Cassone, Antonio
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Benvenuto, Domenico
Angeletti, Silvia
Giovanetti, Marta
Bianchi, Marina
Pascarella, Stefano
Cauda, Roberto
Ciccozzi, Massimo
Cassone, Antonio
dc.subject.other.pt_BR.fl_str_mv SARS-CoV-2
Análise evolutiva
Proteína não estrutural 6
Autofagia viral
COVID-19
Coronavírus
topic SARS-CoV-2
Análise evolutiva
Proteína não estrutural 6
Autofagia viral
COVID-19
Coronavírus
SARS-CoV-2
Evolutionary analysis
Non-Structural Protein 6
Viral autophagy
COVID-19
Coronavirus
dc.subject.en.pt_BR.fl_str_mv SARS-CoV-2
Evolutionary analysis
Non-Structural Protein 6
Viral autophagy
COVID-19
Coronavirus
description Devido a pandemia mundial do COVID-19, o artigo da revista foi liberado em acesso aberto durante o ano de 2020, visando divulgação e disseminação.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-04-14T19:13:38Z
dc.date.available.fl_str_mv 2020-04-14T19:13:38Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BENVENUTO, Domenico et al. Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy. Journal of Infection, p. 1-10, Mar. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40756
dc.identifier.issn.pt_BR.fl_str_mv 0163-4453
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.jinf.2020.03.058
identifier_str_mv BENVENUTO, Domenico et al. Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy. Journal of Infection, p. 1-10, Mar. 2020.
0163-4453
10.1016/j.jinf.2020.03.058
url https://www.arca.fiocruz.br/handle/icict/40756
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/40756/1/license.txt
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