Effectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control study

Detalhes bibliográficos
Autor(a) principal: Ichihara, Maria Y. T
Data de Publicação: 2014
Outros Autores: Rodrigues, Laura C, Santos, Carlos A. S. Teles, Teixeira, Maria da Gloria L. C, Jesus, Sandra R. de, Matos, Sheila M. Alvim de, Leite, Jose P. Gagliardi, Barreto, Maurício L
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10819
Resumo: Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
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spelling Ichihara, Maria Y. TRodrigues, Laura CSantos, Carlos A. S. TelesTeixeira, Maria da Gloria L. CJesus, Sandra R. deMatos, Sheila M. Alvim deLeite, Jose P. GagliardiBarreto, Maurício L2015-06-12T13:57:51Z2015-06-12T13:57:51Z2014ICHIHARA, Maria Y. T. et al. Effectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control study. Vaccine, v.32, n.23, p.2740-2747, 2014.0264-410Xhttps://www.arca.fiocruz.br/handle/icict/1081910.1016/j.vaccine.2014.01.007engElsevierCriançasHospitalizaçãoRotavirus diarrheaVaccine effectivenessAcute diarrhea hospitalizationChild diarrheaVaccineHospitalizationRotavirusDiarréiaVacinaEffectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.London School of Hygiene and Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.Universidade Estadual de Feira de Santana. Departamento de Ciências Exatas. Feira de Santana, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Campus Anísio Teixeira. Instituto Multidisciplinar de Saúde. Vitória da Conquista, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Rotavirus is one of the leading cause of hospitalization and outpatients visits among children under five years. This study evaluated overall and genotype-specific vaccine effectiveness of oral monovalent rotavirus vaccine (G1P[8] strain) in preventing hospital admission of Brazilian children with rotavirus acute diarrhea. A hospital based case-control study was conducted in five Regions of Brazil using the National Rotavirus Acute Diarrhea Surveillance System from July 2008 to August 2011. A total of 215 cases (aged 4-24 months) admitted with confirmed rotavirus diarrhea were recruited and 1961 controls hospitalized without diarrhea were frequency matched by sex and age group to cases. Two-dose adjusted vaccine effectiveness (adjusted by year of birth and the frequency matching variables) was 76% (95%CI: 58-86) lasting for two years. Effectiveness controlled by the available potential confounders was 72% (95%CI: 44-85), suggesting no appreciable confounding by those factors for which adjustment was made. In a half of the cases the rotavirus genotype was G2P[4] and in 15% G1P[8]. Genotype-specific VE (two doses) was 89% (95%CI: 78-95), for G1P[8] and 76% (95%CI: 64-84) for G2P[4]. For all G1, it was 74% (95%CI: 35-90), for all G2, 76% (95%CI: 63-84), and for all non G1/G2 genotypes, 63% (95%CI: -27-99). Effectiveness for one dose was 62% (95%CI: 39-97). Effectiveness of two-dose monovalent rotavirus vaccine in preventing hospital admission with rotavirus diarrhea was high, lasted for two years and it was similar against both G1P[8] and G2P[4]. Based on the findings of the study we recommend the continued use of rotavirus in the Brazilian National Immunization Program and the monitoring of the early emergence of unusual and novel rotavirus genotypes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10819/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALjose_leiteetal_IOC_2014.pdfapplication/pdf825534https://www.arca.fiocruz.br/bitstream/icict/10819/2/jose_leiteetal_IOC_2014.pdf3cccbd4bedf8c596fa80718f784fe488MD52TEXTjose_leiteetal_IOC_2014.pdf.txtjose_leiteetal_IOC_2014.pdf.txtExtracted texttext/plain45798https://www.arca.fiocruz.br/bitstream/icict/10819/3/jose_leiteetal_IOC_2014.pdf.txt9821c8b2b7ee1d1a048e4c0634e9e71eMD53icict/108192022-06-24 12:18:58.703oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:18:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Effectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control study
title Effectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control study
spellingShingle Effectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control study
Ichihara, Maria Y. T
Crianças
Hospitalização
Rotavirus diarrhea
Vaccine effectiveness
Acute diarrhea hospitalization
Child diarrhea
Vaccine
Hospitalization
Rotavirus
Diarréia
Vacina
title_short Effectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control study
title_full Effectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control study
title_fullStr Effectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control study
title_full_unstemmed Effectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control study
title_sort Effectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control study
author Ichihara, Maria Y. T
author_facet Ichihara, Maria Y. T
Rodrigues, Laura C
Santos, Carlos A. S. Teles
Teixeira, Maria da Gloria L. C
Jesus, Sandra R. de
Matos, Sheila M. Alvim de
Leite, Jose P. Gagliardi
Barreto, Maurício L
author_role author
author2 Rodrigues, Laura C
Santos, Carlos A. S. Teles
Teixeira, Maria da Gloria L. C
Jesus, Sandra R. de
Matos, Sheila M. Alvim de
Leite, Jose P. Gagliardi
Barreto, Maurício L
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ichihara, Maria Y. T
Rodrigues, Laura C
Santos, Carlos A. S. Teles
Teixeira, Maria da Gloria L. C
Jesus, Sandra R. de
Matos, Sheila M. Alvim de
Leite, Jose P. Gagliardi
Barreto, Maurício L
dc.subject.other.pt_BR.fl_str_mv Crianças
Hospitalização
topic Crianças
Hospitalização
Rotavirus diarrhea
Vaccine effectiveness
Acute diarrhea hospitalization
Child diarrhea
Vaccine
Hospitalization
Rotavirus
Diarréia
Vacina
dc.subject.en.pt_BR.fl_str_mv Rotavirus diarrhea
Vaccine effectiveness
Acute diarrhea hospitalization
Child diarrhea
Vaccine
Hospitalization
dc.subject.decs.pt_BR.fl_str_mv Rotavirus
Diarréia
Vacina
description Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-06-12T13:57:51Z
dc.date.available.fl_str_mv 2015-06-12T13:57:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ICHIHARA, Maria Y. T. et al. Effectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control study. Vaccine, v.32, n.23, p.2740-2747, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10819
dc.identifier.issn.pt_BR.fl_str_mv 0264-410X
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.vaccine.2014.01.007
identifier_str_mv ICHIHARA, Maria Y. T. et al. Effectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control study. Vaccine, v.32, n.23, p.2740-2747, 2014.
0264-410X
10.1016/j.vaccine.2014.01.007
url https://www.arca.fiocruz.br/handle/icict/10819
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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