Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31313 |
Resumo: | National Council for Research (CNPq), Research Foundation of Bahia State (FAPESB), and Funding Authority for Studies and Projects (FINEP). |
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Larocca, Ticiana FerreiraSouza, Bruno Solano de FreitasMacêdo, Carolina ThéAzevedo, Carine MachadoVasconcelos, Juliana FragaSilva, Daniela NascimentoPortella, Diogo Crispim NascimentodosSantos, Washington Luis ConradoTavora, Fabio Rocha FernandesSouza Neto, João David deSantos, Ricardo Ribeiro dosSoares, Milena Botelho Pereira2019-01-25T17:58:58Z2019-01-25T17:58:58Z2018LAROCCA, T. F. et al. Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy. Surgical and Experimental Pathology, 2018.2520-8454https://www.arca.fiocruz.br/handle/icict/31313National Council for Research (CNPq), Research Foundation of Bahia State (FAPESB), and Funding Authority for Studies and Projects (FINEP).Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade federal da Bahia. Salvador, BA, Brasil.Messejana Hospital. Fortaleza, CE, Brasil.Messejana Hospital. Fortaleza, CE, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Chronic Chagas cardiomyopathy (CCC) is characterized by the presence of a multifocal inflammatory response and myocardial damage, leading to fibrosis, arrhythmias and ventricular dysfunction. The expression of syndecan-4, a transmembrane proteoglycan, was previously found to be increased in the hearts of mice chronically infected with Trypanosoma cruzi. The possible involvement of syndecan-4 in the disease pathogenesis, however, remains unknown. Here we evaluated the pattern of expression of syndecan-4 in the heart tissue of T. cruzi infected mice and subjects with Chagas cardiomyopathy, correlating with the degree of inflammation and fibrosis.engBMCSíndecan-4Doença de ChagasCardiomiopatiaSyndecan-4Chagas diseaseCardiomyopathyAssessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31313/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLAROCCA,T.F. Assessment of syndecan-4...2018.pdfLAROCCA,T.F. 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| dc.title.pt_BR.fl_str_mv |
Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy |
| title |
Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy |
| spellingShingle |
Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy Larocca, Ticiana Ferreira Síndecan-4 Doença de Chagas Cardiomiopatia Syndecan-4 Chagas disease Cardiomyopathy |
| title_short |
Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy |
| title_full |
Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy |
| title_fullStr |
Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy |
| title_full_unstemmed |
Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy |
| title_sort |
Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy |
| author |
Larocca, Ticiana Ferreira |
| author_facet |
Larocca, Ticiana Ferreira Souza, Bruno Solano de Freitas Macêdo, Carolina Thé Azevedo, Carine Machado Vasconcelos, Juliana Fraga Silva, Daniela Nascimento Portella, Diogo Crispim Nascimento dosSantos, Washington Luis Conrado Tavora, Fabio Rocha Fernandes Souza Neto, João David de Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Souza, Bruno Solano de Freitas Macêdo, Carolina Thé Azevedo, Carine Machado Vasconcelos, Juliana Fraga Silva, Daniela Nascimento Portella, Diogo Crispim Nascimento dosSantos, Washington Luis Conrado Tavora, Fabio Rocha Fernandes Souza Neto, João David de Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Larocca, Ticiana Ferreira Souza, Bruno Solano de Freitas Macêdo, Carolina Thé Azevedo, Carine Machado Vasconcelos, Juliana Fraga Silva, Daniela Nascimento Portella, Diogo Crispim Nascimento dosSantos, Washington Luis Conrado Tavora, Fabio Rocha Fernandes Souza Neto, João David de Santos, Ricardo Ribeiro dos Soares, Milena Botelho Pereira |
| dc.subject.other.pt_BR.fl_str_mv |
Síndecan-4 Doença de Chagas Cardiomiopatia |
| topic |
Síndecan-4 Doença de Chagas Cardiomiopatia Syndecan-4 Chagas disease Cardiomyopathy |
| dc.subject.en.pt_BR.fl_str_mv |
Syndecan-4 Chagas disease Cardiomyopathy |
| description |
National Council for Research (CNPq), Research Foundation of Bahia State (FAPESB), and Funding Authority for Studies and Projects (FINEP). |
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2018 |
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2018 |
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2019-01-25T17:58:58Z |
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2019-01-25T17:58:58Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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LAROCCA, T. F. et al. Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy. Surgical and Experimental Pathology, 2018. |
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https://www.arca.fiocruz.br/handle/icict/31313 |
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2520-8454 |
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LAROCCA, T. F. et al. Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy. Surgical and Experimental Pathology, 2018. 2520-8454 |
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