Leptospira and inflammation
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19013 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. |
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Albuquerque, C. F. Gonçalves deBurth, P.Silva, A. R.Younes-Ibrahim, M.Faria Neto, H. C. CastroFaria, M. V. Castro2017-05-25T18:22:23Z2017-05-25T18:22:23Z2012ALBUQUERQUE, C. F. Gonçalves; et al. Leptospira and Inflammation. Mediators of Inflammation, Volume 2012, Article ID 317950, 11p, 2012.0962-9351https://www.arca.fiocruz.br/handle/icict/1901310.1155/2012/3179501466-1861)engHindawi Publishing CorporationLeptospiroseInflamaçãoLeptospirosisInflammationLeptospira and inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil.Leptospirosis is an important zoonosis and has a worldwide impact on public health. This paper will discuss both the role of immunogenic and pathogenic molecules during leptospirosis infection and possible new targets for immunotherapy against leptospira components. Leptospira, possess a wide variety of mechanisms that allow them to evade the host immune system and cause infection. Many molecules contribute to the ability of Leptospira to adhere, invade, and colonize. The recent sequencing of the Leptospira genome has increased our knowledge about this pathogen. Although the virulence factors, molecular targets, mechanisms of inflammation, and signaling pathways triggered by leptospiral antigens have been studied, some questions are still unanswered. Toll-like receptors (TLRs) are the primary sensors of invading pathogens. TLRs recognize conserved microbial pattern molecules and activate signaling pathways that are pivotal to innate and adaptive immune responses. Recently, a new molecular target has emerged--the Na/K-ATPase--which may contribute to inflammatory and metabolic alteration in this syndrome. Na/K-ATPase is a target for specific fatty acids of host origin and for bacterial components such as the glycolipoprotein fraction (GLP) that may lead to inflammasome activation. We propose that in addition to TLRs, Na/K-ATPase may play a role in the innate response to leptospirosis infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19013/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALcf_albuquerque_etal_IOC_2012.pdfcf_albuquerque_etal_IOC_2012.pdfapplication/pdf1692788https://www.arca.fiocruz.br/bitstream/icict/19013/2/cf_albuquerque_etal_IOC_2012.pdfb9994d4358e9855225c2de06f7acc42eMD52TEXTcf_albuquerque_etal_IOC_2012.pdf.txtcf_albuquerque_etal_IOC_2012.pdf.txtExtracted texttext/plain66559https://www.arca.fiocruz.br/bitstream/icict/19013/3/cf_albuquerque_etal_IOC_2012.pdf.txt00dd354aa5fcb84ac0eca9d1b66de5d2MD53icict/190132018-08-15 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dc.title.pt_BR.fl_str_mv |
Leptospira and inflammation |
title |
Leptospira and inflammation |
spellingShingle |
Leptospira and inflammation Albuquerque, C. F. Gonçalves de Leptospirose Inflamação Leptospirosis Inflammation |
title_short |
Leptospira and inflammation |
title_full |
Leptospira and inflammation |
title_fullStr |
Leptospira and inflammation |
title_full_unstemmed |
Leptospira and inflammation |
title_sort |
Leptospira and inflammation |
author |
Albuquerque, C. F. Gonçalves de |
author_facet |
Albuquerque, C. F. Gonçalves de Burth, P. Silva, A. R. Younes-Ibrahim, M. Faria Neto, H. C. Castro Faria, M. V. Castro |
author_role |
author |
author2 |
Burth, P. Silva, A. R. Younes-Ibrahim, M. Faria Neto, H. C. Castro Faria, M. V. Castro |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Albuquerque, C. F. Gonçalves de Burth, P. Silva, A. R. Younes-Ibrahim, M. Faria Neto, H. C. Castro Faria, M. V. Castro |
dc.subject.other.pt_BR.fl_str_mv |
Leptospirose Inflamação |
topic |
Leptospirose Inflamação Leptospirosis Inflammation |
dc.subject.en.pt_BR.fl_str_mv |
Leptospirosis Inflammation |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2017-05-25T18:22:23Z |
dc.date.available.fl_str_mv |
2017-05-25T18:22:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ALBUQUERQUE, C. F. Gonçalves; et al. Leptospira and Inflammation. Mediators of Inflammation, Volume 2012, Article ID 317950, 11p, 2012. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/19013 |
dc.identifier.issn.pt_BR.fl_str_mv |
0962-9351 |
dc.identifier.doi.none.fl_str_mv |
10.1155/2012/317950 |
dc.identifier.eissn.none.fl_str_mv |
1466-1861) |
identifier_str_mv |
ALBUQUERQUE, C. F. Gonçalves; et al. Leptospira and Inflammation. Mediators of Inflammation, Volume 2012, Article ID 317950, 11p, 2012. 0962-9351 10.1155/2012/317950 1466-1861) |
url |
https://www.arca.fiocruz.br/handle/icict/19013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
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FIOCRUZ |
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