Physical disabilities caused by leprosy in 100 million cohort in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47687 |
Resumo: | Medical Research Council (MRC) (MR/N017250/1) |
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Sanchez, Mauro NiskierNery, Joilda SilvaPescarini, Júlia MoreiraMendes, André AlvesIchihara, Maria YuryTeixeira, Camila Silveira SilvaPenna, Maria Lúcia FernandesSmeeth, LiamRodrigues, Laura CunhaBarreto, Maurício LimaBrickley, Elizabeth B.Penna, Gerson Oliveira2021-06-15T12:42:45Z2021-06-15T12:42:45Z2021SANCHEZ, Mauro Niskier et al. Physical disabilities caused by leprosy in 100 million cohort in Brazil. BMC Infectious Diseases, v. 21, n. 290, p. 1-11, 22 Mar. 2021.1471-2334https://www.arca.fiocruz.br/handle/icict/4768710.1186/s12879-021-05846-w1471-2334Medical Research Council (MRC) (MR/N017250/1)CONFAP/ESRC/MRC/BBSRC/CNPq/FAPDF 2015 – Neglected Tropical Diseases (FAP-DF 193.000.008/2016)Wellcome Trust (Grant 202912/Z/16/Z)Universidade de Brasília. Núcleo de Medicina Tropical. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil / Universidade Federal Bahia. Instituto de Matemática. Departamento de Estatística. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal Fluminense. Instituto de Saúde Coletiva. Departamento de Epidemiologia e Bioestatística. Hospital Universitário Antônio Pedro. Niterói, RJ, Brasil.School of Hygiene & Tropical Medicine. Department of Non-Communicable Disease Epidemiology. London, UK / Health Data Research. London, UK.London School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, UK.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil.London School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, UK.Fundação Oswaldo Cruz. Fiocruz Brasília. Escola Fiocruz de Governo. Brasília, DF, Brasil.Background: Leprosy continues to be an important cause of physical disability in endemic countries such as Brazil. Knowledge of determinants of these events may lead to better control measures and targeted interventions to mitigate its impact on affected individuals. This study investigated such factors among the most vulnerable portion of the Brazilian population. Methods: A large cohort was built from secondary data originated from a national registry of applicants to social benefit programs, covering the period 2001–2015, including over 114 million individuals. Data were linked to the leprosy notification system utilizing data from 2007 until 2014. Descriptive and bivariate analyses lead to a multivariate analysis using a multinomial logistic regression model with cluster-robust standard errors. Associations were reported as Odds Ratios with their respective 95% confidence intervals. Results: Among the original cohort members 21,565 new leprosy cases were identified between 2007 and 2014. Most of the cases (63.1%) had grade zero disability. Grades 1 and 2 represented 21 and 6%, respectively. Factors associated with increasing odds of grades 1 and 2 disability were age over 15 years old (ORs 2.39 and 1.95, respectively), less schooling (with a clear dose response effect) and being a multibacillary patient (ORs 3.5 and 8.22). Protective factors for both grades were being female (ORs 0.81 and 0.61) and living in a high incidence municipality (ORs 0.85 and 0.67). Conclusions: The findings suggest that the developing of physical disabilities remains a public health problem which increases the burden of leprosy, mainly for those with severe clinical features and worse socioeconomic conditions. Early diagnosis is paramount to decrease the incidence of leprosy-related disability and our study points to the need for strengthening control actions in non-endemic areas in Brazil, where cases may be missed when presented at early stages in disease. Both actions are needed, to benefit patients and to achieve the WHO goal in reducing physical disabilities among new cases of leprosy.engBMCDeficiência físicaHanseníaseFator socioeconômicoBrasilFatores de proteçãoPhysical disabilitiesLeprosySocioeconomic factorBrazilPhysical disabilities caused by leprosy in 100 million cohort in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/47687/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSanchez, Mauro Niskier Physical....pdfSanchez, Mauro Niskier Physical....pdfapplication/pdf759301https://www.arca.fiocruz.br/bitstream/icict/47687/2/Sanchez%2c%20Mauro%20Niskier%20Physical....pdf0064761a337a6885bfe6fac01d4682bfMD52TEXTSanchez, Mauro Niskier Physical....pdf.txtSanchez, 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| dc.title.en.fl_str_mv |
Physical disabilities caused by leprosy in 100 million cohort in Brazil |
| title |
Physical disabilities caused by leprosy in 100 million cohort in Brazil |
| spellingShingle |
Physical disabilities caused by leprosy in 100 million cohort in Brazil Sanchez, Mauro Niskier Deficiência física Hanseníase Fator socioeconômico Brasil Fatores de proteção Physical disabilities Leprosy Socioeconomic factor Brazil |
| title_short |
Physical disabilities caused by leprosy in 100 million cohort in Brazil |
| title_full |
Physical disabilities caused by leprosy in 100 million cohort in Brazil |
| title_fullStr |
Physical disabilities caused by leprosy in 100 million cohort in Brazil |
| title_full_unstemmed |
Physical disabilities caused by leprosy in 100 million cohort in Brazil |
| title_sort |
Physical disabilities caused by leprosy in 100 million cohort in Brazil |
| author |
Sanchez, Mauro Niskier |
| author_facet |
Sanchez, Mauro Niskier Nery, Joilda Silva Pescarini, Júlia Moreira Mendes, André Alves Ichihara, Maria Yury Teixeira, Camila Silveira Silva Penna, Maria Lúcia Fernandes Smeeth, Liam Rodrigues, Laura Cunha Barreto, Maurício Lima Brickley, Elizabeth B. Penna, Gerson Oliveira |
| author_role |
author |
| author2 |
Nery, Joilda Silva Pescarini, Júlia Moreira Mendes, André Alves Ichihara, Maria Yury Teixeira, Camila Silveira Silva Penna, Maria Lúcia Fernandes Smeeth, Liam Rodrigues, Laura Cunha Barreto, Maurício Lima Brickley, Elizabeth B. Penna, Gerson Oliveira |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sanchez, Mauro Niskier Nery, Joilda Silva Pescarini, Júlia Moreira Mendes, André Alves Ichihara, Maria Yury Teixeira, Camila Silveira Silva Penna, Maria Lúcia Fernandes Smeeth, Liam Rodrigues, Laura Cunha Barreto, Maurício Lima Brickley, Elizabeth B. Penna, Gerson Oliveira |
| dc.subject.other.pt_BR.fl_str_mv |
Deficiência física Hanseníase Fator socioeconômico Brasil Fatores de proteção |
| topic |
Deficiência física Hanseníase Fator socioeconômico Brasil Fatores de proteção Physical disabilities Leprosy Socioeconomic factor Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
Physical disabilities Leprosy Socioeconomic factor Brazil |
| description |
Medical Research Council (MRC) (MR/N017250/1) |
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2021 |
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2021-06-15T12:42:45Z |
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2021-06-15T12:42:45Z |
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2021 |
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SANCHEZ, Mauro Niskier et al. Physical disabilities caused by leprosy in 100 million cohort in Brazil. BMC Infectious Diseases, v. 21, n. 290, p. 1-11, 22 Mar. 2021. |
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https://www.arca.fiocruz.br/handle/icict/47687 |
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1471-2334 |
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10.1186/s12879-021-05846-w |
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1471-2334 |
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SANCHEZ, Mauro Niskier et al. Physical disabilities caused by leprosy in 100 million cohort in Brazil. BMC Infectious Diseases, v. 21, n. 290, p. 1-11, 22 Mar. 2021. 1471-2334 10.1186/s12879-021-05846-w |
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