Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45080 |
Resumo: | Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação Alfredo da Matta. Laboratório de Biologia Molecular. Manaus, AM, Brasil. |
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Leturiondo, André LuizNoronha, Ariani BatistaMendonça, Carla Yael RibeiroFerreira, Cynthia de OliveiraAlvarado-Arnez, Lucia ElenaManta, Fernanda Saloum de NevesBezerra, Ohanna Cavalcanti de LimaCarvalho, Elizeu Fagundes deMoraes, Milton OzórioRodrigues, Fabíola da CostaTalhari, Carolina2020-12-22T18:53:11Z2020-12-22T18:53:11Z2020LETURIONDO, André Luiz et al. Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population. Plos Neglected Tropical Diseases, v. 14, n. 5, p. 1-13, May 2020.1935-2727https://www.arca.fiocruz.br/handle/icict/4508010.1371/journal.pntd.00082471935-2735engPublic Library of ScienceHanseníaseNOD2IFNGAssociaçãoPolimorfismos de nucleotídeosEtnia amazônicaAmazôniaPopulaçãoLeprosyNOD2IFNGAssociationSingle nucleotide polymorphismsAmazon ethnic admixed populationAssociation of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação Alfredo da Matta. Laboratório de Biologia Molecular. Manaus, AM, Brasil.Fundação Alfredo da Matta. Laboratório de Biologia Molecular. Manaus, AM, Brasil.Fundação Alfredo da Matta. Laboratório de Biologia Molecular. Manaus, AM, Brasil.Fundação Alfredo da Matta. Laboratório de Biologia Molecular. Manaus, AM, Brasil.Universidad Franz Tamayo/UNIFRANZ. Coordinación de Investigación. La Paz, Bolivia / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Diagnóstico por DNA. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Alfredo da Matta. Laboratório de Biologia Molecular. Manaus, AM, Brasil.Fundação Alfredo da Matta. Laboratório de Biologia Molecular. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Universidade Nilton Lins. Curso de Medicina. Manaus, AM, Brasil.Leprosy is a chronic infectious disease, caused by Mycobacterium leprae, which affects skin and peripheral nerves. Polymorphisms in genes associated with autophagy, metabolism, innate and adaptive immunity confer susceptibility to leprosy. However, these associations need to be confirmed through independent replication studies in different ethnicities. The population from Amazon state (northern Brazil) is admixed and it contains the highest proportion of Native American genetic ancestry in Brazil. We conducted a case-control study for leprosy in which we tested fourteen previously associated SNPs in key immune response regulating genes: TLR1 (rs4833095), NOD2 (rs751271, rs8057341), TNF (rs1800629), IL10 (rs1800871), CCDC122/LACC1 (rs4942254), PACRG/PRKN (rs9356058, rs1040079), IFNG (rs2430561), IL6 (rs2069845), LRRK2 (rs7298930, rs3761863), IL23R (rs76418789) and TYK2 (rs55882956). Genotyping was carried out by allelic discrimination in 967 controls and 412 leprosy patients. Association with susceptibility was assessed by logistic regression analyses adjusted for the following covariates: gender, age and ancestry. Genetic ancestry was similar in case and control groups. Statistically significant results were only found for IFNG and NOD2. The rs8057341 polymorphism within NOD2 was identified as significant for the AA genotype (OR = 0.56; 95% CI, 0.37–0.84; P = 0.005) and borderline for the A allele (OR = 0.76; 95% CI, 0.58–1.00; P = 0.053) and carrier (OR = 0.76; 95% CI, 0.58–1.00; P = 0.051). The rs2430561 SNP in IFNG was associated with disease susceptibility for the AT genotype (OR = 1.40; 95% CI, 1.06–1.85; P = 0.018) and carrier (OR = 1.44; 95% CI, 1.10–1.88; P = 0.008). We confirmed that NOD2 and IFNG are major players in immunity against M.leprae in the Amazon ethnic admixed population.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45080/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOhannaC_Bezerra_etal_IOC_2020.pdfOhannaC_Bezerra_etal_IOC_2020.pdfapplication/pdf641914https://www.arca.fiocruz.br/bitstream/icict/45080/2/OhannaC_Bezerra_etal_IOC_2020.pdf2a3a0b10211ec996d78c4094ccccc9f5MD52TEXTOhannaC_Bezerra_etal_IOC_2020.pdf.txtOhannaC_Bezerra_etal_IOC_2020.pdf.txtExtracted texttext/plain48715https://www.arca.fiocruz.br/bitstream/icict/45080/3/OhannaC_Bezerra_etal_IOC_2020.pdf.txt2f1126da31ff7df71152f1f9b8789ec4MD53icict/450802021-03-12 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| dc.title.pt_BR.fl_str_mv |
Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population |
| title |
Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population |
| spellingShingle |
Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population Leturiondo, André Luiz Hanseníase NOD2 IFNG Associação Polimorfismos de nucleotídeos Etnia amazônica Amazônia População Leprosy NOD2 IFNG Association Single nucleotide polymorphisms Amazon ethnic admixed population |
| title_short |
Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population |
| title_full |
Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population |
| title_fullStr |
Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population |
| title_full_unstemmed |
Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population |
| title_sort |
Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population |
| author |
Leturiondo, André Luiz |
| author_facet |
Leturiondo, André Luiz Noronha, Ariani Batista Mendonça, Carla Yael Ribeiro Ferreira, Cynthia de Oliveira Alvarado-Arnez, Lucia Elena Manta, Fernanda Saloum de Neves Bezerra, Ohanna Cavalcanti de Lima Carvalho, Elizeu Fagundes de Moraes, Milton Ozório Rodrigues, Fabíola da Costa Talhari, Carolina |
| author_role |
author |
| author2 |
Noronha, Ariani Batista Mendonça, Carla Yael Ribeiro Ferreira, Cynthia de Oliveira Alvarado-Arnez, Lucia Elena Manta, Fernanda Saloum de Neves Bezerra, Ohanna Cavalcanti de Lima Carvalho, Elizeu Fagundes de Moraes, Milton Ozório Rodrigues, Fabíola da Costa Talhari, Carolina |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Leturiondo, André Luiz Noronha, Ariani Batista Mendonça, Carla Yael Ribeiro Ferreira, Cynthia de Oliveira Alvarado-Arnez, Lucia Elena Manta, Fernanda Saloum de Neves Bezerra, Ohanna Cavalcanti de Lima Carvalho, Elizeu Fagundes de Moraes, Milton Ozório Rodrigues, Fabíola da Costa Talhari, Carolina |
| dc.subject.other.pt_BR.fl_str_mv |
Hanseníase NOD2 IFNG Associação Polimorfismos de nucleotídeos Etnia amazônica Amazônia População |
| topic |
Hanseníase NOD2 IFNG Associação Polimorfismos de nucleotídeos Etnia amazônica Amazônia População Leprosy NOD2 IFNG Association Single nucleotide polymorphisms Amazon ethnic admixed population |
| dc.subject.en.pt_BR.fl_str_mv |
Leprosy NOD2 IFNG Association Single nucleotide polymorphisms Amazon ethnic admixed population |
| description |
Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação Alfredo da Matta. Laboratório de Biologia Molecular. Manaus, AM, Brasil. |
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2020 |
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2020-12-22T18:53:11Z |
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2020-12-22T18:53:11Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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LETURIONDO, André Luiz et al. Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population. Plos Neglected Tropical Diseases, v. 14, n. 5, p. 1-13, May 2020. |
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https://www.arca.fiocruz.br/handle/icict/45080 |
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1935-2727 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0008247 |
| dc.identifier.eissn.none.fl_str_mv |
1935-2735 |
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LETURIONDO, André Luiz et al. Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population. Plos Neglected Tropical Diseases, v. 14, n. 5, p. 1-13, May 2020. 1935-2727 10.1371/journal.pntd.0008247 1935-2735 |
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