Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8736 |
Resumo: | Jackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/ Jackson State University. Department of Biology. Jackson, Mississippi, USA. |
| id |
CRUZ_4c0da3da0123648c1340004c8ddd09a4 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/8736 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Isokpehi, Raphael D.Mahmud, OusmanMbah, Andreas N.Simmons, Shaneka S.Avelar, Livia das Gracas AmaralRajnarayanan, Rajendram V.Udensi, Udensi K.Ayensu, Wellington K.Cohly, Hari H.Brown, Shyretha D.Dates, Centdrika R.Hentz, Sonya D.Hughes, Shawntae J.Smith McInnis, Dominique R.Patterson, Carvey O.Sims, Jennifer N.Turner, Kelisha T.Williams, Baraka S.Johnson, Matilda O.Adubi, TaiwoMbuh, Judith V.Anumudu, Chiaka I.Adeoye, Grace O.Thomas, Bolaji N.Nashiru, OyekanmiOliveira, Guilherme Corrêa2014-11-06T12:33:58Z2014-11-06T12:33:58Z2011ISOKPEHI, Raphael D. et al. Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni. Gene Regulation and Systems Biology, 5: 61-74, 2011.1177-6250https://www.arca.fiocruz.br/handle/icict/873610.4137/GRSB.S7491engLibertas AcademicaDevelopmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/ Jackson State University. Department of Biology. Jackson, Mississippi, USA.Jackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/ Jackson State University. Department of Biology. Jackson, Mississippi, USA.Jackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USAJackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/ Jackson State University. Department of Biology. Jackson, Mississippi, USA.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo de Genética e Biologia Computacional. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Departamento de Genética. Belo Horizonte, MG, Brazil.State University of New York at Buffalo. Department of Pharmacology and Toxicology Buffalo, New York, USA.Jackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/ Jackson State University. Department of Biology. Jackson, Mississippi, USA.Jackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/ Jackson State University. Department of Biology. Jackson, Mississippi, USA.Jackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/ Jackson State University. Department of Biology. Jackson, Mississippi, USA.Jackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/ Jackson State University. Department of Biology. Jackson, Mississippi, USA.Jackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/ Jackson State University. Department of Biology. Jackson, Mississippi, USA.Jackson State University. Department of Biology. Jackson, Mississippi, USA.Jackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/ Jackson State University. Department of Biology. Jackson, Mississippi, USA.Jackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/ Jackson State University. Department of Biology. Jackson, Mississippi, USA.Jackson State University. Department of Biology. Jackson, Mississippi, USA.Jackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/ Jackson State University. Department of Biology. Jackson, Mississippi, USA.Jackson State University. Department of Biology. Jackson, Mississippi, USA.Jackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/Jackson State University. Department of Biology. Jackson, Mississippi, USA.University of South Africa. Department of Environmental Sciences. Pretoria, South Africa.International Center for Genetic Engineering and Biotechnology/National Biotechnology Development Agency/West African Biotechnology Workshop Series, IbadanNigeria. University of Lagos. Department of Zoology. Akoka, Yaba, Lagos, Nigeria.International Center for Genetic Engineering and Biotechnology/ University of Buea. Department of Life Sciences. Buea, CameroonInternational Center for Genetic Engineering and Biotechnology/ University of Ibadan. Department of Zoology. Ibadan, Nigeria.International Center for Genetic Engineering and Biotechnology/National Biotechnology Development Agency/West African Biotechnology Workshop Series, IbadanNigeria. University of Lagos. Department of Zoology. Akoka, Yaba, Lagos, Nigeria.Rochester Institute of Technology. Department of Biological and Medical Sciences. Rochester, New York, USA.National Biotechnology Development Agency. Department of Molecular Biology and Bioinformatics. Abuja, Nigeria/ West African Biotechnology Workshop Series, Ibadan, Nigeria.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo de Genética e Biologia Computacional. Belo Horizonte, MG, Brazil.The draft nuclear genome sequence of the snail-transmitted, dimorphic, parasitic, platyhelminth Schistosoma mansoni revealed eight genes encoding proteins that contain the Universal Stress Protein (USP) domain. Schistosoma mansoni is a causative agent of human schistosomiasis, a severe and debilitating Neglected Tropical Disease (NTD) of poverty, which is endemic in at least 76 countries. The availability of the genome sequences of Schistosoma species presents opportunities for bioinformatics and genomics analyses of associated gene families that could be targets for understanding schistosomiasis ecology, intervention, prevention and control. Proteins with the USP domain are known to provide bacteria, archaea, fungi, protists and plants with the ability to respond to diverse environmental stresses. In this research investigation, the functional annotations of the USP genes and predicted nucleotide and protein sequences were initially verified. Subsequently, sequence clusters and distinctive features of the sequences were determined. A total of twelve ligand binding sites were predicted based on alignment to the ATP-binding universal stress protein from Methanocaldococcus jannaschii. In addition, six USP sequences showed the presence of ATP-binding motif residues indicating that they may be regulated by ATP. Public domain gene expression data and RT-PCR assays confirmed that all the S. mansoni USP genes were transcribed in at least one of the developmental life cycle stages of the helminth. Six of these genes were up-regulated in the miracidium, a free-swimming stage that is critical for transmission to the snail intermediate host. It is possible that during the intra-snail stages, S. mansoni gene transcripts for universal stress proteins are low abundant and are induced to perform specialized functions triggered by environmental stressors such as oxidative stress due to hydrogen peroxide that is present in the snail hemocytes. This report serves to catalyze the formation of a network of researchers to understand the function and regulation of the universal stress proteins encoded in genomes of schistosomes and their snail intermediate hosts.Schistosomaexpressed sequence tagsgene regulationprotein domainsserial analysis of gene expressionuniversal stress proteinsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8736/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALDevelopmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni.pdfDevelopmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni.pdfapplication/pdf2258164https://www.arca.fiocruz.br/bitstream/icict/8736/2/Developmental%20Regulation%20of%20Genes%20Encoding%20Universal%20Stress%20Proteins%20in%20Schistosoma%20mansoni.pdf9f4c1f92e5258517700960b2d82059c8MD52TEXTDevelopmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni.pdf.txtDevelopmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni.pdf.txtExtracted texttext/plain61876https://www.arca.fiocruz.br/bitstream/icict/8736/3/Developmental%20Regulation%20of%20Genes%20Encoding%20Universal%20Stress%20Proteins%20in%20Schistosoma%20mansoni.pdf.txt8dfe20c0dafed0dd7046e891a8d0936cMD53icict/87362019-06-19 10:13:25.958oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:13:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni |
| title |
Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni |
| spellingShingle |
Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni Isokpehi, Raphael D. Schistosoma expressed sequence tags gene regulation protein domains serial analysis of gene expression universal stress proteins |
| title_short |
Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni |
| title_full |
Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni |
| title_fullStr |
Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni |
| title_full_unstemmed |
Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni |
| title_sort |
Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni |
| author |
Isokpehi, Raphael D. |
| author_facet |
Isokpehi, Raphael D. Mahmud, Ousman Mbah, Andreas N. Simmons, Shaneka S. Avelar, Livia das Gracas Amaral Rajnarayanan, Rajendram V. Udensi, Udensi K. Ayensu, Wellington K. Cohly, Hari H. Brown, Shyretha D. Dates, Centdrika R. Hentz, Sonya D. Hughes, Shawntae J. Smith McInnis, Dominique R. Patterson, Carvey O. Sims, Jennifer N. Turner, Kelisha T. Williams, Baraka S. Johnson, Matilda O. Adubi, Taiwo Mbuh, Judith V. Anumudu, Chiaka I. Adeoye, Grace O. Thomas, Bolaji N. Nashiru, Oyekanmi Oliveira, Guilherme Corrêa |
| author_role |
author |
| author2 |
Mahmud, Ousman Mbah, Andreas N. Simmons, Shaneka S. Avelar, Livia das Gracas Amaral Rajnarayanan, Rajendram V. Udensi, Udensi K. Ayensu, Wellington K. Cohly, Hari H. Brown, Shyretha D. Dates, Centdrika R. Hentz, Sonya D. Hughes, Shawntae J. Smith McInnis, Dominique R. Patterson, Carvey O. Sims, Jennifer N. Turner, Kelisha T. Williams, Baraka S. Johnson, Matilda O. Adubi, Taiwo Mbuh, Judith V. Anumudu, Chiaka I. Adeoye, Grace O. Thomas, Bolaji N. Nashiru, Oyekanmi Oliveira, Guilherme Corrêa |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Isokpehi, Raphael D. Mahmud, Ousman Mbah, Andreas N. Simmons, Shaneka S. Avelar, Livia das Gracas Amaral Rajnarayanan, Rajendram V. Udensi, Udensi K. Ayensu, Wellington K. Cohly, Hari H. Brown, Shyretha D. Dates, Centdrika R. Hentz, Sonya D. Hughes, Shawntae J. Smith McInnis, Dominique R. Patterson, Carvey O. Sims, Jennifer N. Turner, Kelisha T. Williams, Baraka S. Johnson, Matilda O. Adubi, Taiwo Mbuh, Judith V. Anumudu, Chiaka I. Adeoye, Grace O. Thomas, Bolaji N. Nashiru, Oyekanmi Oliveira, Guilherme Corrêa |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosoma expressed sequence tags gene regulation protein domains serial analysis of gene expression universal stress proteins |
| topic |
Schistosoma expressed sequence tags gene regulation protein domains serial analysis of gene expression universal stress proteins |
| description |
Jackson State University. Department of Biology. Center for Bioinformatics & Computational Biology. Jackson, Mississippi, USA/ Jackson State University. Department of Biology. Jackson, Mississippi, USA. |
| publishDate |
2011 |
| dc.date.issued.fl_str_mv |
2011 |
| dc.date.accessioned.fl_str_mv |
2014-11-06T12:33:58Z |
| dc.date.available.fl_str_mv |
2014-11-06T12:33:58Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
ISOKPEHI, Raphael D. et al. Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni. Gene Regulation and Systems Biology, 5: 61-74, 2011. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/8736 |
| dc.identifier.issn.none.fl_str_mv |
1177-6250 |
| dc.identifier.doi.none.fl_str_mv |
10.4137/GRSB.S7491 |
| identifier_str_mv |
ISOKPEHI, Raphael D. et al. Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni. Gene Regulation and Systems Biology, 5: 61-74, 2011. 1177-6250 10.4137/GRSB.S7491 |
| url |
https://www.arca.fiocruz.br/handle/icict/8736 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Libertas Academica |
| publisher.none.fl_str_mv |
Libertas Academica |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/8736/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/8736/2/Developmental%20Regulation%20of%20Genes%20Encoding%20Universal%20Stress%20Proteins%20in%20Schistosoma%20mansoni.pdf https://www.arca.fiocruz.br/bitstream/icict/8736/3/Developmental%20Regulation%20of%20Genes%20Encoding%20Universal%20Stress%20Proteins%20in%20Schistosoma%20mansoni.pdf.txt |
| bitstream.checksum.fl_str_mv |
7d48279ffeed55da8dfe2f8e81f3b81f 9f4c1f92e5258517700960b2d82059c8 8dfe20c0dafed0dd7046e891a8d0936c |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009292499877888 |