Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Marilda de Souza
Data de Publicação: 2010
Outros Autores: Moura Neto, José Pereira de, Souza, C. L., Melo, P., Reis, Mitermayer Galvão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7948
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Department of Clinical and Toxicology Analyses. Salvador, BA, Brasil
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spelling Gonçalves, Marilda de SouzaMoura Neto, José Pereira deSouza, C. L.Melo, P.Reis, Mitermayer Galvão dos2014-07-14T16:16:56Z2014-07-14T16:16:56Z2010GONÇALVES, M. S. et al. Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia. International Journal of Laboratory Hematology, v. 32, n. 1 Pt 1, p. e49-56, 2010.1751-553Xhttps://www.arca.fiocruz.br/handle/icict/794810.1111/j.1751-553X.2009.01169.xengBlackwell PublishingEvaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Department of Clinical and Toxicology Analyses. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Department of Clinical and Toxicology Analyses. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil / Laboratório de Análises Clínicas Labchecap. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, BrasilGlutathione S-transferase (GST) enzymes protect cells against xenobiotics and oxidative stress products through an electrophilic conjugation process. We investigated the theta (GSTT1) and mu (GSTM1) null genotypes in a group of leukopenic subjects and normal subjects from Northeast Brazil, evaluating their use as biomarkers of susceptibility for developing leukopenia. In a sample-based case–control study, we analysed white blood cell (WBC) counts and GSTT1 and GSTM1 genotypes. A total of 278 subjects were analysed: 91 with leukopenia and 187 controls. GSTT1 null genotype conferred a 5.92-fold risk for occurrence of leukopenia [odds ratios (OR) = 5.92, CIMLE: 1.64–26.72, PMLE = 0.002] and a 3.90-fold risk of neutropenia (OR = 3.90; CIMLE: 1.05–13.66; PMLE = 0.02), while GSTM1 null genotype conferred a 1.78-fold risk for leukopenia (OR = 1.75; CIMLE: 1.04–3.06, PMLE = 0.017) and no risk of neutropenia (OR = 1.71; CIMLE: 0.88– 3.35; PMLE = 0.06). The GSTT1, but not the GSTM1 null genotype, was found to be associated with leukopenia and neutropenia. More cellular and molecular studies are needed to evaluate the existence of genotype interactions, and to confirm the appropriateness of using the GSTT1 and/or GSTM1 null genotypes as biomarkers of susceptibility to white blood-cell deficiencies.Glutathione S-transferaseLeukopeniaEthnic groupBiomarkerLeukocytesMarcadores Biológicos/sangueGlutationa Transferase/genéticaLeucopenia/genéticaAdultoBrasilFemininoDeleção de GenesPredisposição Genética para DoençaGenótipoHumanosMasculinoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGonçalves MS Evaluating glutathione....pdfGonçalves MS Evaluating glutathione....pdfapplication/pdf147493https://www.arca.fiocruz.br/bitstream/icict/7948/1/Gon%c3%a7alves%20MS%20Evaluating%20glutathione....pdf15477931f3ac3962253c9568eda81cc6MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7948/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTGonçalves MS Evaluating glutathione....pdf.txtGonçalves MS Evaluating glutathione....pdf.txtExtracted texttext/plain32965https://www.arca.fiocruz.br/bitstream/icict/7948/3/Gon%c3%a7alves%20MS%20Evaluating%20glutathione....pdf.txt17f1b2862edaea55793c44ca9833bf48MD53icict/79482023-03-15 14:33:21.084oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.
title Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.
spellingShingle Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.
Gonçalves, Marilda de Souza
Glutathione S-transferase
Leukopenia
Ethnic group
Biomarker
Leukocytes
Marcadores Biológicos/sangue
Glutationa Transferase/genética
Leucopenia/genética
Adulto
Brasil
Feminino
Deleção de Genes
Predisposição Genética para Doença
Genótipo
Humanos
Masculino
title_short Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.
title_full Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.
title_fullStr Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.
title_full_unstemmed Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.
title_sort Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.
author Gonçalves, Marilda de Souza
author_facet Gonçalves, Marilda de Souza
Moura Neto, José Pereira de
Souza, C. L.
Melo, P.
Reis, Mitermayer Galvão dos
author_role author
author2 Moura Neto, José Pereira de
Souza, C. L.
Melo, P.
Reis, Mitermayer Galvão dos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gonçalves, Marilda de Souza
Moura Neto, José Pereira de
Souza, C. L.
Melo, P.
Reis, Mitermayer Galvão dos
dc.subject.en.pt_BR.fl_str_mv Glutathione S-transferase
Leukopenia
Ethnic group
Biomarker
Leukocytes
topic Glutathione S-transferase
Leukopenia
Ethnic group
Biomarker
Leukocytes
Marcadores Biológicos/sangue
Glutationa Transferase/genética
Leucopenia/genética
Adulto
Brasil
Feminino
Deleção de Genes
Predisposição Genética para Doença
Genótipo
Humanos
Masculino
dc.subject.decs.pt_BR.fl_str_mv Marcadores Biológicos/sangue
Glutationa Transferase/genética
Leucopenia/genética
Adulto
Brasil
Feminino
Deleção de Genes
Predisposição Genética para Doença
Genótipo
Humanos
Masculino
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Pathology and Molecular Biology Laboratory. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Department of Clinical and Toxicology Analyses. Salvador, BA, Brasil
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2014-07-14T16:16:56Z
dc.date.available.fl_str_mv 2014-07-14T16:16:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GONÇALVES, M. S. et al. Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia. International Journal of Laboratory Hematology, v. 32, n. 1 Pt 1, p. e49-56, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7948
dc.identifier.issn.none.fl_str_mv 1751-553X
dc.identifier.doi.none.fl_str_mv 10.1111/j.1751-553X.2009.01169.x
identifier_str_mv GONÇALVES, M. S. et al. Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia. International Journal of Laboratory Hematology, v. 32, n. 1 Pt 1, p. e49-56, 2010.
1751-553X
10.1111/j.1751-553X.2009.01169.x
url https://www.arca.fiocruz.br/handle/icict/7948
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/7948/1/Gon%c3%a7alves%20MS%20Evaluating%20glutathione....pdf
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