Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32371 |
Resumo: | Pontifícia Universidade Católica de Goiás. Goiânia, GO, Brasil / Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil. |
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Botelho, Sílvia M.Ferreira, Renata C.Reis, Nádia R. S.Kozlowski, Aline G.Carneiro, Megmar A. S.Teles, Sheila A.Yoshida, Clara F. T.Martins, Regina M. B.2019-04-04T15:24:38Z2019-04-04T15:24:38Z2008BOTELHO, Sílvia M. et al. Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 5, p. 472-476, Aug. 2008.0074-0276https://www.arca.fiocruz.br/handle/icict/3237110.1590/S0074-027620080005000111678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzVÍrus da Hepatite CFatores de RiscoPrevalênciaGenótiposReceptores de transplante renalHepatitis C virusRenal transplant recipientsPrevalenceRisk factorsALTGenotypesAlanina TransaminaseEpidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePontifícia Universidade Católica de Goiás. Goiânia, GO, Brasil / Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil.Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil / Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil.Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil / Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil.Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil / Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil.Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil./ Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil.Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil./ Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil./ Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil.An investigation was conducted involving 255 renal transplant recipients in the state of Goiás, Central Brazil, to determine the prevalence of hepatitis C virus (HCV), its risk factors, the genotypes involved, and the level of alanine aminotransferase (ALT) present in the patients. All serum samples were tested for anti-HCV antibodies and HCV RNA. Forty-one patients were anti-HCV and/or HCV RNA positive, resulting in an overall HCV infection prevalence of 16.1% (95% CI: 11.9-21.3). A multivariate analysis of risk factors showed that a history of blood transfusions without anti-HCV screening, the length of time spent on hemodialysis, and renal transplantation before 1994 are all associated with HCV positivity. In HCV-positive patients, only 12.2% had ALT levels above normal. Twenty-eight samples were genotyped as genotype 1, subtypes 1a (62.5%) and 1b (31.3%), and two samples (6.2%) were genotype 3, subtype 3a. These data show a high prevalence of HCV infection and low ALT levels in the studied population. The risk factor analysis findings emphasize the importance of public health strategies such as anti-HCV screening of candidate blood and organ donors, in addition to the stricter adoption of hemodialysis-specific infection control measures. The present study also demonstrates that HCV genotype 1 (subtype 1a) is predominant in this population.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32371/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALClara_Yoshida_etal_IOC_2008.pdfClara_Yoshida_etal_IOC_2008.pdfapplication/pdf322136https://www.arca.fiocruz.br/bitstream/icict/32371/2/Clara_Yoshida_etal_IOC_2008.pdf234f7f6db171ccf5d8b4d7fd42a39a6fMD52TEXTClara_Yoshida_etal_IOC_2008.pdf.txtClara_Yoshida_etal_IOC_2008.pdf.txtExtracted texttext/plain24369https://www.arca.fiocruz.br/bitstream/icict/32371/3/Clara_Yoshida_etal_IOC_2008.pdf.txt5477149fc039191057340b45d06e0462MD53icict/323712019-04-10 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| dc.title.pt_BR.fl_str_mv |
Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil |
| title |
Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil |
| spellingShingle |
Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil Botelho, Sílvia M. VÍrus da Hepatite C Fatores de Risco Prevalência Genótipos Receptores de transplante renal Hepatitis C virus Renal transplant recipients Prevalence Risk factors ALT Genotypes Alanina Transaminase |
| title_short |
Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil |
| title_full |
Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil |
| title_fullStr |
Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil |
| title_full_unstemmed |
Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil |
| title_sort |
Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil |
| author |
Botelho, Sílvia M. |
| author_facet |
Botelho, Sílvia M. Ferreira, Renata C. Reis, Nádia R. S. Kozlowski, Aline G. Carneiro, Megmar A. S. Teles, Sheila A. Yoshida, Clara F. T. Martins, Regina M. B. |
| author_role |
author |
| author2 |
Ferreira, Renata C. Reis, Nádia R. S. Kozlowski, Aline G. Carneiro, Megmar A. S. Teles, Sheila A. Yoshida, Clara F. T. Martins, Regina M. B. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Botelho, Sílvia M. Ferreira, Renata C. Reis, Nádia R. S. Kozlowski, Aline G. Carneiro, Megmar A. S. Teles, Sheila A. Yoshida, Clara F. T. Martins, Regina M. B. |
| dc.subject.other.pt_BR.fl_str_mv |
VÍrus da Hepatite C Fatores de Risco Prevalência Genótipos Receptores de transplante renal |
| topic |
VÍrus da Hepatite C Fatores de Risco Prevalência Genótipos Receptores de transplante renal Hepatitis C virus Renal transplant recipients Prevalence Risk factors ALT Genotypes Alanina Transaminase |
| dc.subject.en.pt_BR.fl_str_mv |
Hepatitis C virus Renal transplant recipients Prevalence Risk factors ALT Genotypes |
| dc.subject.decs.pt_BR.fl_str_mv |
Alanina Transaminase |
| description |
Pontifícia Universidade Católica de Goiás. Goiânia, GO, Brasil / Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil. |
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2008 |
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2008 |
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2019-04-04T15:24:38Z |
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2019-04-04T15:24:38Z |
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BOTELHO, Sílvia M. et al. Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 5, p. 472-476, Aug. 2008. |
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https://www.arca.fiocruz.br/handle/icict/32371 |
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0074-0276 |
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10.1590/S0074-02762008000500011 |
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1678-8060 |
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BOTELHO, Sílvia M. et al. Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 5, p. 472-476, Aug. 2008. 0074-0276 10.1590/S0074-02762008000500011 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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