The c-Myc-tag role in anti-CD19 scFv labeling and CAR’s function alteration: an in silico, in vitro and in vivo study

Detalhes bibliográficos
Autor(a) principal: Lima, Ana Julia Ferreira
Data de Publicação: 2022
Outros Autores: Hajdu, Karina Lôbo, Abdo, Luiza de Macedo, Bonamino, Martín Hernán, Lourenzoni, Marcos Roberto
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/52184
Resumo: Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.
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spelling Lima, Ana Julia FerreiraHajdu, Karina LôboAbdo, Luiza de MacedoBonamino, Martín HernánLourenzoni, Marcos Roberto2022-04-12T17:16:49Z2022-04-12T17:16:49Z2022LIMA, A. J. F. et al. The c-Myc-tag role in anti-CD19 scFv labeling and CAR’s function alteration: an in silico, in vitro and in vivo study. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 6., 2022. Rio de Janeiro. Annals... Rio de Janeiro: Bio-Manguinhos, 2022. p. 92.https://www.arca.fiocruz.br/handle/icict/5218410.35259/isi.2022_52184Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.Universidade Federal do Ceará. Fortaleza, CE, Brasil.Instituto Nacional do Câncer. Programa de Carcinogênese Molecular Coordenação de Pesquisa. Rio de Janeiro, RJ, Brasil.Instituto Nacional do Câncer. Programa de Carcinogênese Molecular Coordenação de Pesquisa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Vice-Presidência de Pesquisa e Coleções Biológicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Fiocruz Ceará. Grupo de Engenharia de Proteínas e Soluções para Saúde. Eusébio, CE, Brasil.engFiocruz/Instituto de Tecnologia em ImunobiológicosCAR-Tc-Myc-tagAntígenos CD19CAR-Tc-Myc-tagCD19Antígenos CD19The c-Myc-tag role in anti-CD19 scFv labeling and CAR’s function alteration: an in silico, in vitro and in vivo studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/52184/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALAnais6thISI2022_92.pdfAnais6thISI2022_92.pdfapplication/pdf178104https://www.arca.fiocruz.br/bitstream/icict/52184/2/Anais6thISI2022_92.pdfffb75e13a43e199218a66f410cb2af1eMD52icict/521842023-04-26 16:56:33.414oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-26T19:56:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The c-Myc-tag role in anti-CD19 scFv labeling and CAR’s function alteration: an in silico, in vitro and in vivo study
title The c-Myc-tag role in anti-CD19 scFv labeling and CAR’s function alteration: an in silico, in vitro and in vivo study
spellingShingle The c-Myc-tag role in anti-CD19 scFv labeling and CAR’s function alteration: an in silico, in vitro and in vivo study
Lima, Ana Julia Ferreira
CAR-T
c-Myc-tag
Antígenos CD19
CAR-T
c-Myc-tag
CD19
Antígenos CD19
title_short The c-Myc-tag role in anti-CD19 scFv labeling and CAR’s function alteration: an in silico, in vitro and in vivo study
title_full The c-Myc-tag role in anti-CD19 scFv labeling and CAR’s function alteration: an in silico, in vitro and in vivo study
title_fullStr The c-Myc-tag role in anti-CD19 scFv labeling and CAR’s function alteration: an in silico, in vitro and in vivo study
title_full_unstemmed The c-Myc-tag role in anti-CD19 scFv labeling and CAR’s function alteration: an in silico, in vitro and in vivo study
title_sort The c-Myc-tag role in anti-CD19 scFv labeling and CAR’s function alteration: an in silico, in vitro and in vivo study
author Lima, Ana Julia Ferreira
author_facet Lima, Ana Julia Ferreira
Hajdu, Karina Lôbo
Abdo, Luiza de Macedo
Bonamino, Martín Hernán
Lourenzoni, Marcos Roberto
author_role author
author2 Hajdu, Karina Lôbo
Abdo, Luiza de Macedo
Bonamino, Martín Hernán
Lourenzoni, Marcos Roberto
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lima, Ana Julia Ferreira
Hajdu, Karina Lôbo
Abdo, Luiza de Macedo
Bonamino, Martín Hernán
Lourenzoni, Marcos Roberto
dc.subject.other.pt_BR.fl_str_mv CAR-T
c-Myc-tag
Antígenos CD19
topic CAR-T
c-Myc-tag
Antígenos CD19
CAR-T
c-Myc-tag
CD19
Antígenos CD19
dc.subject.en.pt_BR.fl_str_mv CAR-T
c-Myc-tag
CD19
dc.subject.decs.pt_BR.fl_str_mv Antígenos CD19
description Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-04-12T17:16:49Z
dc.date.available.fl_str_mv 2022-04-12T17:16:49Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, A. J. F. et al. The c-Myc-tag role in anti-CD19 scFv labeling and CAR’s function alteration: an in silico, in vitro and in vivo study. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 6., 2022. Rio de Janeiro. Annals... Rio de Janeiro: Bio-Manguinhos, 2022. p. 92.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/52184
dc.identifier.doi.none.fl_str_mv 10.35259/isi.2022_52184
identifier_str_mv LIMA, A. J. F. et al. The c-Myc-tag role in anti-CD19 scFv labeling and CAR’s function alteration: an in silico, in vitro and in vivo study. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 6., 2022. Rio de Janeiro. Annals... Rio de Janeiro: Bio-Manguinhos, 2022. p. 92.
10.35259/isi.2022_52184
url https://www.arca.fiocruz.br/handle/icict/52184
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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