Human T lymphotropic virus typ7e 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis,1 and other neurological abnormalities associated with HTLV-1 infection

Detalhes bibliográficos
Autor(a) principal: Silva, Marcus Tulius T.
Data de Publicação: 2007
Outros Autores: Harab, Ramza Cabral, Leite, Ana Cláudia, Schor, Doris, Araújo, Abelardo, Andrada-Serpa, Maria José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57660
Resumo: We thank Marcos A. M. Scheiner and Beatriz J. Pereira Vaz for the first experiments of proviral load. We thank Prof. William Hall and Dr. Carla Vorsatz for their review of the English in this manuscript. Financial support. Brazilian National Research Council (CNPq), Fundac¸a˜o Oswaldo Cruz, and Brazilian Health Ministry. Potential conflicts of interest. All authors: no conflicts.
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spelling Silva, Marcus Tulius T.Harab, Ramza CabralLeite, Ana CláudiaSchor, DorisAraújo, AbelardoAndrada-Serpa, Maria José2023-04-03T14:57:04Z2023-04-03T14:57:04Z2007SILVA, Marcus Tulius T. et al. Human T lymphotropic virus type 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis, and other neurological abnormalities associated with HTLV-1 infection. Clinical Infectious Diseases, v. 44, n. 5, p. 689-692, Mar. 2007.1058-4838https://www.arca.fiocruz.br/handle/icict/5766010.1086/5106791537-6591We thank Marcos A. M. Scheiner and Beatriz J. Pereira Vaz for the first experiments of proviral load. We thank Prof. William Hall and Dr. Carla Vorsatz for their review of the English in this manuscript. Financial support. Brazilian National Research Council (CNPq), Fundac¸a˜o Oswaldo Cruz, and Brazilian Health Ministry. Potential conflicts of interest. All authors: no conflicts.Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Reference Center for Neuroinfection Diseases. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratory of Virology. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Reference Center for Neuroinfection Diseases and HTLV. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratory of Virology. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Reference Center for Neuroinfection Diseases and HTLV. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratory of Virology. Reference Center for Neuroinfection Diseases and HTLV. Rio de Janeiro, RJ, Brazil.Recent reports have demonstrated that human T lymphotropic virus type 1 (HTLV-1) is associated with other neurological abnormalities in addition to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It has been well established that high HTLV-1 proviral loads are associated with the development of HAM/TSP. We now demonstrate, for the first time, to our knowledge, that HTLV-1 proviral loads in patients with other neurological abnormalities are also significantly higher than in asymptomatic HTLV-1 carriers.engOxford University PressHuman T lymphotropic virus typ7e 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis,1 and other neurological abnormalities associated with HTLV-1 infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHuman T lymphotropic virus type 1 (HTLV-1)Asymptomatic CarriersNeurological AbnormalitiesHTLV-1 Infectioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSilva_Marcus_etal_INI_2007.pdfSilva_Marcus_etal_INI_2007.pdfapplication/pdf113716https://www.arca.fiocruz.br/bitstream/icict/57660/2/Silva_Marcus_etal_INI_2007.pdfee10d5b7e1c6b2bd4e67024c0b71f499MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57660/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/576602023-04-03 12:02:09.191oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-03T15:02:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Human T lymphotropic virus typ7e 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis,1 and other neurological abnormalities associated with HTLV-1 infection
title Human T lymphotropic virus typ7e 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis,1 and other neurological abnormalities associated with HTLV-1 infection
spellingShingle Human T lymphotropic virus typ7e 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis,1 and other neurological abnormalities associated with HTLV-1 infection
Silva, Marcus Tulius T.
Human T lymphotropic virus type 1 (HTLV-1)
Asymptomatic Carriers
Neurological Abnormalities
HTLV-1 Infection
title_short Human T lymphotropic virus typ7e 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis,1 and other neurological abnormalities associated with HTLV-1 infection
title_full Human T lymphotropic virus typ7e 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis,1 and other neurological abnormalities associated with HTLV-1 infection
title_fullStr Human T lymphotropic virus typ7e 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis,1 and other neurological abnormalities associated with HTLV-1 infection
title_full_unstemmed Human T lymphotropic virus typ7e 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis,1 and other neurological abnormalities associated with HTLV-1 infection
title_sort Human T lymphotropic virus typ7e 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis,1 and other neurological abnormalities associated with HTLV-1 infection
author Silva, Marcus Tulius T.
author_facet Silva, Marcus Tulius T.
Harab, Ramza Cabral
Leite, Ana Cláudia
Schor, Doris
Araújo, Abelardo
Andrada-Serpa, Maria José
author_role author
author2 Harab, Ramza Cabral
Leite, Ana Cláudia
Schor, Doris
Araújo, Abelardo
Andrada-Serpa, Maria José
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Marcus Tulius T.
Harab, Ramza Cabral
Leite, Ana Cláudia
Schor, Doris
Araújo, Abelardo
Andrada-Serpa, Maria José
dc.subject.en.en_US.fl_str_mv Human T lymphotropic virus type 1 (HTLV-1)
Asymptomatic Carriers
Neurological Abnormalities
HTLV-1 Infection
topic Human T lymphotropic virus type 1 (HTLV-1)
Asymptomatic Carriers
Neurological Abnormalities
HTLV-1 Infection
description We thank Marcos A. M. Scheiner and Beatriz J. Pereira Vaz for the first experiments of proviral load. We thank Prof. William Hall and Dr. Carla Vorsatz for their review of the English in this manuscript. Financial support. Brazilian National Research Council (CNPq), Fundac¸a˜o Oswaldo Cruz, and Brazilian Health Ministry. Potential conflicts of interest. All authors: no conflicts.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2023-04-03T14:57:04Z
dc.date.available.fl_str_mv 2023-04-03T14:57:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv SILVA, Marcus Tulius T. et al. Human T lymphotropic virus type 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis, and other neurological abnormalities associated with HTLV-1 infection. Clinical Infectious Diseases, v. 44, n. 5, p. 689-692, Mar. 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57660
dc.identifier.issn.en_US.fl_str_mv 1058-4838
dc.identifier.doi.none.fl_str_mv 10.1086/510679
dc.identifier.eissn.none.fl_str_mv 1537-6591
identifier_str_mv SILVA, Marcus Tulius T. et al. Human T lymphotropic virus type 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis, and other neurological abnormalities associated with HTLV-1 infection. Clinical Infectious Diseases, v. 44, n. 5, p. 689-692, Mar. 2007.
1058-4838
10.1086/510679
1537-6591
url https://www.arca.fiocruz.br/handle/icict/57660
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dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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