Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years.

Detalhes bibliográficos
Autor(a) principal: Santana, Carolina Souza
Data de Publicação: 2023
Outros Autores: Andrade, Felipe de Oliveira, Silva, Greice Carolina Santos da, Nascimento, Jéssica Oliveira de Souza, Campos, Raissa Frazão, Giovanetti, Marta, Santos, Luciane Amorim, Gois, Luana Leandro, Alcantara, Luiz Carlos Júnior, Barreto, Fernanda Khouri
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57398
Resumo: Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Vitória da Conquista, BA, Brazil.
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spelling Santana, Carolina SouzaAndrade, Felipe de OliveiraSilva, Greice Carolina Santos daNascimento, Jéssica Oliveira de SouzaCampos, Raissa FrazãoGiovanetti, MartaSantos, Luciane AmorimGois, Luana LeandroAlcantara, Luiz Carlos JúniorBarreto, Fernanda Khouri2023-03-16T12:40:26Z2023-03-16T12:40:26Z2023SANTANA, Carolina Souza et al. Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years. Frontiers in immunology, v. 14, p. 1073779, 2023. 14, 1073779. 14:1073779. doi: 10.3389/fimmu.2023.1073779.1664-3224https://www.arca.fiocruz.br/handle/icict/57398engFrontiers Research FoundationAdvances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Vitória da Conquista, BA, Brazil.Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Vitória da Conquista, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil.Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Vitória da Conquista, BA, Brazil.Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Vitória da Conquista, BA, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor. Belo Horizonte, MG, Brazil/Department of Science and Technology for Humans and the Environment. University of Campus Bio-Medico di Roma. Rome, ItalyUniversidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Vitória da Conquista, BA, Brazil/Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil/Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor. Belo Horizonte, MG, Brazil.Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Vitória da Conquista, BA, Brazil.Introduction: The Human T-lymphotropic virus type 1 (HTLV-1) was the first described human retrovirus. It is currently estimated that around 5 to 10 million people worldwide are infected with this virus. Despite its high prevalence, there is still no preventive vaccine against the HTLV-1 infection. It is known that vaccine development and large-scale immunization play an important role in global public health. To understand the advances in this field we performed a systematic review regarding the current progress in the development of a preventive vaccine against the HTLV-1 infection. Methods: This review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA®) guidelines and was registered at the International Prospective Register of Systematic Reviews (PROSPERO). The search for articles was performed in PubMed, Lilacs, Embase and SciELO databases. From the 2,485 articles identified, 25 were selected according to the inclusion and exclusion criteria. Results: The analysis of these articles indicated that potential vaccine designs in development are available, although there is still a paucity of studies in the human clinical trial phase. Discussion: Although HTLV-1 was discovered almost 40 years ago, it remains a great challenge and a worldwide neglected threat. The scarcity of funding contributes decisively to the inconclusiveness of the vaccine development. The data summarized here intends to highlight the necessity to improve the current knowledge of this neglected retrovirus, encouraging for more studies on vaccine development aiming the to eliminate this human threat.HTLV-1immunizationpreventionpublic health policiesvaccineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57398/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAdvances in preventive vaccine development against.pdfAdvances in preventive vaccine development against.pdfapplication/pdf1612162https://www.arca.fiocruz.br/bitstream/icict/57398/2/Advances%20in%20preventive%20vaccine%20development%20against.pdf749e9fa5132be6a60622099d47e04699MD52icict/573982023-03-16 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dc.title.en_US.fl_str_mv Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years.
title Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years.
spellingShingle Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years.
Santana, Carolina Souza
HTLV-1
immunization
prevention
public health policies
vaccine
title_short Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years.
title_full Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years.
title_fullStr Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years.
title_full_unstemmed Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years.
title_sort Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years.
author Santana, Carolina Souza
author_facet Santana, Carolina Souza
Andrade, Felipe de Oliveira
Silva, Greice Carolina Santos da
Nascimento, Jéssica Oliveira de Souza
Campos, Raissa Frazão
Giovanetti, Marta
Santos, Luciane Amorim
Gois, Luana Leandro
Alcantara, Luiz Carlos Júnior
Barreto, Fernanda Khouri
author_role author
author2 Andrade, Felipe de Oliveira
Silva, Greice Carolina Santos da
Nascimento, Jéssica Oliveira de Souza
Campos, Raissa Frazão
Giovanetti, Marta
Santos, Luciane Amorim
Gois, Luana Leandro
Alcantara, Luiz Carlos Júnior
Barreto, Fernanda Khouri
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santana, Carolina Souza
Andrade, Felipe de Oliveira
Silva, Greice Carolina Santos da
Nascimento, Jéssica Oliveira de Souza
Campos, Raissa Frazão
Giovanetti, Marta
Santos, Luciane Amorim
Gois, Luana Leandro
Alcantara, Luiz Carlos Júnior
Barreto, Fernanda Khouri
dc.subject.en.en_US.fl_str_mv HTLV-1
immunization
prevention
public health policies
vaccine
topic HTLV-1
immunization
prevention
public health policies
vaccine
description Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Vitória da Conquista, BA, Brazil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-03-16T12:40:26Z
dc.date.available.fl_str_mv 2023-03-16T12:40:26Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTANA, Carolina Souza et al. Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years. Frontiers in immunology, v. 14, p. 1073779, 2023. 14, 1073779. 14:1073779. doi: 10.3389/fimmu.2023.1073779.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57398
dc.identifier.issn.en_US.fl_str_mv 1664-3224
identifier_str_mv SANTANA, Carolina Souza et al. Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years. Frontiers in immunology, v. 14, p. 1073779, 2023. 14, 1073779. 14:1073779. doi: 10.3389/fimmu.2023.1073779.
1664-3224
url https://www.arca.fiocruz.br/handle/icict/57398
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57398/1/license.txt
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