Organophosphate-induced delayed neuropathy

Vasconcellos, L.; Leite, A. C. C. B.; Nascimento, O.

Organophosphate-induced delayed neuropathy

Detalhes bibliográficos
Autor(a) principal:	Vasconcellos, L.
Data de Publicação:	2002
Outros Autores:	Leite, A. C. C. B., Nascimento, O.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/33056
Resumo:	Ana Cláudia Leite. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.

Metadados do item

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spelling	Vasconcellos, L.Leite, A. C. C. B.Nascimento, O.2019-05-14T13:52:02Z2019-05-14T13:52:02Z2002VASCONCELLOS, Luiz Felipe R.; LEITE, Ana Cláudia; NASCIMENTO, Osvaldo J. M. Organophosphate-induced delayed neuropathy. Arquivos de Neuro-Psiquiatria, v. 60, n. 4, p. 1003-1007, 2002.0004-282Xhttps://www.arca.fiocruz.br/handle/icict/3305610.1590/S0004-282X20020006000221678-4227Ana Cláudia Leite. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.A neuropatia tardia dos organofosforados (NTOF) é condição clinica incomum. Geralmente ocorre após a intoxicação aguda por organofosforados, seguindo-se a fase de hiperestimulação colinérgica. O quadro clínico é caracterizado por déficit motor distal nos membros inferiores associado a sintomas sensitivos. O estudo eletroneuromiográfico tem demonstrado padrão axonal motor na maioria dos casos. Podem ocorrer sinais de comprometimento do sistema nervoso central. Descrevemos o caso de uma paciente de 39 anos que ingeriu inseticida a base de Dichlorvos e quatorze dias após apresentou quadro de hiperestesia associado a paresia distal nos membros inferiores. Realizou eletroneuromiografia que se caracterizou por padrão compatível com polineuropatia axonal. Sinais piramidais, de aparecimento mais tardio, foram observados nos membros superiores. Diante do comprometimento do sistema nervoso periférico e central, também consideramos o termo neuropatia tardia por organofosforado (NTOF) mais adequado do que tão somente polineuropatia tardia por organofosforado (PTOF).Organophosphate induced delayed neuropathy (OPIDN) is an uncommon clinical condition. It occurs in association with the ingestion of great amounts of organophosphate after the stimulation of cholinergic receptor. The clinical picture is characterized by a distal paresis in lower limbs associated with sensitive symptoms. Electrodiagnostic studies show a motor axonal neuropathy. Involvement of the central nervous system may occur. We describe a 39 years-old female patient who developed hyperesthesia associated with lower limbs paresis, fourteen days after she had ingested a Dichlorvos-based insecticide. Electrophysiological study was characterized by an axonal polyneuropathy pattern. Pyramidal tract dysfunction was observed later in upper limbs. Considering that both peripheral and central nervous systems are involved we believe that the more appropriated term would be organophosphate induced delayed neuropathy (OPIDN) instead of organophosphate induced delayed polyneuropathy (OPIDP).Federal University of Rio de Janeiro. Institute of Neurology Deolindo Couto. Rio de Janeiro, RJ, Brasil.Federal University of Rio de Janeiro. Institute of Neurology Deolindo Couto. Rio de Janeiro, RJ, Brasil.Federal Fluminense University. Department of Neurology. Niterói RJ, Brasil.engAcademia Brasileira de NeurologiaNeuropatiaPolineuropatiaOrganofosforadosNeuropathyPolyneuropathyOrganophosphateOrganophosphate-induced delayed neuropathyNeuropatia tardia por organofosforado: relato de casoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/33056/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Vasconcellos_Luiz_etal_INI_2002.pdfve_Vasconcellos_Luiz_etal_INI_2002.pdfapplication/pdf145689https://www.arca.fiocruz.br/bitstream/icict/33056/2/ve_Vasconcellos_Luiz_etal_INI_2002.pdf02dd9ea985776fe2c267cb4e385456cfMD52TEXTve_Vasconcellos_Luiz_etal_INI_2002.pdf.txtve_Vasconcellos_Luiz_etal_INI_2002.pdf.txtExtracted texttext/plain18870https://www.arca.fiocruz.br/bitstream/icict/33056/3/ve_Vasconcellos_Luiz_etal_INI_2002.pdf.txtbcc005f0999b54a33c3f20cff408656fMD53icict/330562019-05-15 02:02:03.324oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-05-15T05:02:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Organophosphate-induced delayed neuropathy
dc.title.alternative.pt_BR.fl_str_mv	Neuropatia tardia por organofosforado: relato de caso
title	Organophosphate-induced delayed neuropathy
spellingShingle	Organophosphate-induced delayed neuropathy Vasconcellos, L. Neuropatia Polineuropatia Organofosforados Neuropathy Polyneuropathy Organophosphate
title_short	Organophosphate-induced delayed neuropathy
title_full	Organophosphate-induced delayed neuropathy
title_fullStr	Organophosphate-induced delayed neuropathy
title_full_unstemmed	Organophosphate-induced delayed neuropathy
title_sort	Organophosphate-induced delayed neuropathy
author	Vasconcellos, L.
author_facet	Vasconcellos, L. Leite, A. C. C. B. Nascimento, O.
author_role	author
author2	Leite, A. C. C. B. Nascimento, O.
author2_role	author author
dc.contributor.author.fl_str_mv	Vasconcellos, L. Leite, A. C. C. B. Nascimento, O.
dc.subject.other.pt_BR.fl_str_mv	Neuropatia Polineuropatia Organofosforados
topic	Neuropatia Polineuropatia Organofosforados Neuropathy Polyneuropathy Organophosphate
dc.subject.en.pt_BR.fl_str_mv	Neuropathy Polyneuropathy Organophosphate
description	Ana Cláudia Leite. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate	2002
dc.date.issued.fl_str_mv	2002
dc.date.accessioned.fl_str_mv	2019-05-14T13:52:02Z
dc.date.available.fl_str_mv	2019-05-14T13:52:02Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	VASCONCELLOS, Luiz Felipe R.; LEITE, Ana Cláudia; NASCIMENTO, Osvaldo J. M. Organophosphate-induced delayed neuropathy. Arquivos de Neuro-Psiquiatria, v. 60, n. 4, p. 1003-1007, 2002.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/33056
dc.identifier.issn.pt_BR.fl_str_mv	0004-282X
dc.identifier.doi.none.fl_str_mv	10.1590/S0004-282X2002000600022
dc.identifier.eissn.none.fl_str_mv	1678-4227
identifier_str_mv	VASCONCELLOS, Luiz Felipe R.; LEITE, Ana Cláudia; NASCIMENTO, Osvaldo J. M. Organophosphate-induced delayed neuropathy. Arquivos de Neuro-Psiquiatria, v. 60, n. 4, p. 1003-1007, 2002. 0004-282X 10.1590/S0004-282X2002000600022 1678-4227
url	https://www.arca.fiocruz.br/handle/icict/33056
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv	Academia Brasileira de Neurologia
publisher.none.fl_str_mv	Academia Brasileira de Neurologia
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
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Organophosphate-induced delayed neuropathy

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