Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/3720 http://dx.doi.org/10.1590/S0074-02762005000400018 |
Resumo: | Acknowledgments to the Serviço de Anatomopatologia, Hospital Central do Exército, Rio de Janeiro, for technical support. |
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Silva, Iran Mendonça daThiengo, RobertoConceição, Maria JoséRey, LuisLenzi, Henrique LeonelPereira Filho, EdsonRibeiro, Paulo César2011-12-15T23:05:48Z2011-12-15T23:05:48Z2005SILVA, Iran Mendonça da et al. Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa. Memórias do Instituto Oswaldo Cruz, v.100, n.4, p. 445-449, 2005.0074-0276https://www.arca.fiocruz.br/handle/icict/3720http://dx.doi.org/10.1590/S0074-02762005000400018Acknowledgments to the Serviço de Anatomopatologia, Hospital Central do Exército, Rio de Janeiro, for technical support.Instituto de Biologia do Exército. Divisão de Ensino e Pesquisa. Subdivisão de Pesquisa. Seção de Vigilância Epidemiológica. Rio de Janeiro, RJ, BrasilHospital Central do Exército. Serviço de Urologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Controle de Esquistossomose. Departamento de Medicina Tropical. Rio de Janeiro, RJ, Brasil / Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Controle de Esquistossomose. Departamento de Medicina Tropical. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, BrasilInstituto de Biologia do Exército. Divisão de Ensino e Pesquisa. Subdivisão de Pesquisa. Seção de Vigilância Epidemiológica. Rio de Janeiro, RJ, BrasilInstituto de Biologia do Exército. Divisão de Ensino e Pesquisa. Subdivisão de Pesquisa. Seção de Vigilância Epidemiológica. Rio de Janeiro, RJ, BrasilSeveral cases of therapeutic failure of praziquantel used for the treatment of urinary schistosomiasis have been reported. Alternative drugs, like niridazol and metrifonate, have shown a lower therapeutic effect and more side effects than praziquantel. Twenty-six Brazilian military men (median age of 29 years) with a positive urine parasitological exam who were part of a United Nation peace mission in Mozambique in 1994 were treated with 40 mg/kg body weight praziquantel, single dose. They swimmed in Licungo river (Mocuba city, Mozambique) during the weekends. After this, they presented haematuria, dysuria, polakiuria, and lumbar pain. Control cystoscopy examinations carried out between 6 and 24 months after each treatment (including two additional treatments at a minimum interval of 6 months) revealed the presence of viable eggs. Granulomas in the vesical submucosa were observed in 46.2% (12/26) of the individuals. A vesical biopsy confirmed the presence of granulomas in all of these patients and the presence of viable eggs in 34.3% (9/26) of individuals who no longer excreted eggs in urine. The eggs filled with miracidia showed characteristics of viability. Histopathological examination using different strains demonstrated therapeutic failure and the need for repeated treatment. In this study, we demonstrated a low efficacy of praziquantel in the treatment of schistosomiasis haematobia, and the necessity of the urinary bladder biopsy as criterion of cure.engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSchistosomiasis Therapeutic FailurePraziquantelSchistosoma haematobiumAfricaBrazilSchistosoma haematobiumPraziquantelSchistosoma haematobiumAfricaBrasilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALTherapeutic failure of praziquantel in the treatment of.pdfTherapeutic failure of praziquantel in the treatment of.pdfapplication/pdf7684625https://www.arca.fiocruz.br/bitstream/icict/3720/1/Therapeutic%20failure%20of%20praziquantel%20in%20the%20treatment%20of.pdff9f129d5008151daa48f3f4c5b961ae3MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/3720/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTTherapeutic failure of praziquantel in the treatment of.pdf.txtTherapeutic failure of praziquantel in the treatment of.pdf.txtExtracted texttext/plain23497https://www.arca.fiocruz.br/bitstream/icict/3720/5/Therapeutic%20failure%20of%20praziquantel%20in%20the%20treatment%20of.pdf.txt68af30d87c9103cb59265637ae50d99eMD55THUMBNAILTherapeutic failure of praziquantel in the treatment of.pdf.jpgTherapeutic failure of praziquantel in the treatment of.pdf.jpgGenerated Thumbnailimage/jpeg2524https://www.arca.fiocruz.br/bitstream/icict/3720/4/Therapeutic%20failure%20of%20praziquantel%20in%20the%20treatment%20of.pdf.jpg94cb23a2b597cd0fc64e4ff408484b7bMD54icict/37202018-04-06 09:14:41.277oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T12:14:41Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa |
| title |
Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa |
| spellingShingle |
Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa Silva, Iran Mendonça da Schistosomiasis Therapeutic Failure Praziquantel Schistosoma haematobium Africa Brazil Schistosoma haematobium Praziquantel Schistosoma haematobium Africa Brasil |
| title_short |
Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa |
| title_full |
Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa |
| title_fullStr |
Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa |
| title_full_unstemmed |
Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa |
| title_sort |
Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa |
| author |
Silva, Iran Mendonça da |
| author_facet |
Silva, Iran Mendonça da Thiengo, Roberto Conceição, Maria José Rey, Luis Lenzi, Henrique Leonel Pereira Filho, Edson Ribeiro, Paulo César |
| author_role |
author |
| author2 |
Thiengo, Roberto Conceição, Maria José Rey, Luis Lenzi, Henrique Leonel Pereira Filho, Edson Ribeiro, Paulo César |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Iran Mendonça da Thiengo, Roberto Conceição, Maria José Rey, Luis Lenzi, Henrique Leonel Pereira Filho, Edson Ribeiro, Paulo César |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosomiasis Therapeutic Failure Praziquantel Schistosoma haematobium Africa Brazil |
| topic |
Schistosomiasis Therapeutic Failure Praziquantel Schistosoma haematobium Africa Brazil Schistosoma haematobium Praziquantel Schistosoma haematobium Africa Brasil |
| dc.subject.decs.pt_BR.fl_str_mv |
Schistosoma haematobium Praziquantel Schistosoma haematobium Africa Brasil |
| description |
Acknowledgments to the Serviço de Anatomopatologia, Hospital Central do Exército, Rio de Janeiro, for technical support. |
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2005 |
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2005 |
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2011-12-15T23:05:48Z |
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2011-12-15T23:05:48Z |
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SILVA, Iran Mendonça da et al. Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa. Memórias do Instituto Oswaldo Cruz, v.100, n.4, p. 445-449, 2005. |
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https://www.arca.fiocruz.br/handle/icict/3720 |
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0074-0276 |
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http://dx.doi.org/10.1590/S0074-02762005000400018 |
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SILVA, Iran Mendonça da et al. Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa. Memórias do Instituto Oswaldo Cruz, v.100, n.4, p. 445-449, 2005. 0074-0276 |
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