Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/24999 |
Resumo: | Proep APQ 1620 4.01/15. |
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Carvalho, Viviane do Carmo Vasconcelos deSilva, Lílian Caroliny AmorimWerkhauser, Roberto PereiraMontenegro, Sérgio TavaresSilva, Carlos Gustavo Regis daGomes, Adriana VieiraMorais, Clarice Neuenschwander Lins deMontenegro, Silvia Maria Lucena2018-02-28T15:57:11Z2018-02-28T15:57:11Z2016CARVALHO, V. C. V. et al. Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil. International Journal of Cardiovascular Sciences, v. 29, n. 4, p. 288-294, 2016.2359-4802https://www.arca.fiocruz.br/handle/icict/24999Proep APQ 1620 4.01/15.Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, BrasilReal Hospital Português. Real Hospital do Coração. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Biologia Parasitária. Salvador, BA, BrasilUniversidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, BrasilBackground: Acute coronary syndrome (ACS) is a leading cause of morbidity and mortality worldwide. It is a multifactorial disease caused by obstruction of the coronary arteries by atheromatous plaques and leads to heart ischemia. Several studies suggest that some genetic polymorphisms change the cytokines levels and influence ACS development.Objective: In this study, we evaluated the IL-6 (-174G/C) polymorphism, serum levels of cytokine and its relationship with ACS and the thrombolysis in myocardial infarction (TIMI) risk score. Materials and Methods: A sample of 200 patients with ACS [TIMI risk – Low (70); Intermediate (89); High (41)] in Brazilian population was used. Genotyping was carried out by polymerase chain reaction, followed by DNA sequencing. Results: There was no significant differences in genotype (p = 0.53) and allele (p = 0.32) distributions between ACS patient and without ACS patients groups on IL-6 allelic polymorphism and between the three differents TIMI risk score (p > 0.05). Moreover IL-6 polymorphism did not affect the cytokine levels and these levels were not related to TIMI score. Conclusions: With these results, we suggest that the IL-6 (-174 G/C) polymorphism, until now, is not related to ACS and did not change the levels of the cytokine in studied population. Further studies with different populations should be done to verify those results. It is important to emphasize that, since ACS is a multifactorial disease, other risk factors and other pro-inflammatory cytokines should be assessed to better understand this pathology.engSociedade de Cardiologia do Estado do Rio de JaneiroSíndrome coronariana agudaIsquemia do miocárdioPolimorfismo, genéticoInterleucina-6Acute Coronary SyndromeMyocardial IschemiaPolymorphism, GeneticInterleukin-6Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24999/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarvalho VC Evaluation of IL-6 (-174 GC) Polymorphism....pdfCarvalho VC Evaluation of IL-6 (-174 GC) 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| dc.title.pt_BR.fl_str_mv |
Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil |
| title |
Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil |
| spellingShingle |
Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil Carvalho, Viviane do Carmo Vasconcelos de Síndrome coronariana aguda Isquemia do miocárdio Polimorfismo, genético Interleucina-6 Acute Coronary Syndrome Myocardial Ischemia Polymorphism, Genetic Interleukin-6 |
| title_short |
Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil |
| title_full |
Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil |
| title_fullStr |
Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil |
| title_full_unstemmed |
Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil |
| title_sort |
Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil |
| author |
Carvalho, Viviane do Carmo Vasconcelos de |
| author_facet |
Carvalho, Viviane do Carmo Vasconcelos de Silva, Lílian Caroliny Amorim Werkhauser, Roberto Pereira Montenegro, Sérgio Tavares Silva, Carlos Gustavo Regis da Gomes, Adriana Vieira Morais, Clarice Neuenschwander Lins de Montenegro, Silvia Maria Lucena |
| author_role |
author |
| author2 |
Silva, Lílian Caroliny Amorim Werkhauser, Roberto Pereira Montenegro, Sérgio Tavares Silva, Carlos Gustavo Regis da Gomes, Adriana Vieira Morais, Clarice Neuenschwander Lins de Montenegro, Silvia Maria Lucena |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carvalho, Viviane do Carmo Vasconcelos de Silva, Lílian Caroliny Amorim Werkhauser, Roberto Pereira Montenegro, Sérgio Tavares Silva, Carlos Gustavo Regis da Gomes, Adriana Vieira Morais, Clarice Neuenschwander Lins de Montenegro, Silvia Maria Lucena |
| dc.subject.other.pt_BR.fl_str_mv |
Síndrome coronariana aguda Isquemia do miocárdio Polimorfismo, genético Interleucina-6 |
| topic |
Síndrome coronariana aguda Isquemia do miocárdio Polimorfismo, genético Interleucina-6 Acute Coronary Syndrome Myocardial Ischemia Polymorphism, Genetic Interleukin-6 |
| dc.subject.en.pt_BR.fl_str_mv |
Acute Coronary Syndrome Myocardial Ischemia Polymorphism, Genetic Interleukin-6 |
| description |
Proep APQ 1620 4.01/15. |
| publishDate |
2016 |
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2016 |
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2018-02-28T15:57:11Z |
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2018-02-28T15:57:11Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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CARVALHO, V. C. V. et al. Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil. International Journal of Cardiovascular Sciences, v. 29, n. 4, p. 288-294, 2016. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/24999 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2359-4802 |
| identifier_str_mv |
CARVALHO, V. C. V. et al. Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil. International Journal of Cardiovascular Sciences, v. 29, n. 4, p. 288-294, 2016. 2359-4802 |
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Sociedade de Cardiologia do Estado do Rio de Janeiro |
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Sociedade de Cardiologia do Estado do Rio de Janeiro |
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