Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50550 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Espíndola, Otávio M.Gomes, Yago C. P.Brandão, Carlos OtávioTorres, Rafael C.Siqueira, Marilda Agudo Mendonça Teixeira deSoares, Cristiane N.Lima, Marco Antonio S. D.Leite, Ana Claudia C. B.Venturotti, Carolina O.Carvalho, Ana Julia C.Torezani, GuilhermeAraujo, Abelardo Q. C.Silva, Marcus Tulius T.2021-12-29T00:11:59Z2021-12-29T00:11:59Z2021Espíndola, Otávio M. et al. Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019. Annals of Neurology, v. 89, n. 5, p. 1041-1045, 2021.0364-5134https://www.arca.fiocruz.br/handle/icict/5055010.1002/ana.26041engWileyInflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Laboratório Neurolife. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Plataforma de imuno-análise. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto Martagão Gesteira de Puericultura e Pediatria. Serviço de Citometria de Fluxo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Hospital do Servidor do Estado do Rio de Janeiro. Departamento de Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Hospital do Servidor do Estado do Rio de Janeiro. Departamento de Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.Hospital do Servidor do Estado do Rio de Janeiro. Departamento de Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Complexo Hospitalar de Niterói. Serviço de Neurologia. Niterói, SP, Brasil.Patients with coronavirus disease 2019 (COVID-19) can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels of interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12, chemokine (C-X-C motif) ligand 8 (CXCL8), and CXCL10 in the cerebrospinal fluid. Conversely, encephalopathy was associated with high serum levels of IL-6, CXCL8, and active tumor growth factor β1. Inflammatory syndromes of the central nervous system in COVID-19 can appear early, as a parainfectious process without significant systemic involvement, or without direct evidence of severe acute respiratory syndrome coronavirus 2 neuroinvasion. At the same time, encephalopathy is mainly influenced by peripheral events, including inflammatory cytokines.COVID-19Inflammatory neurological diseasesCentral nervous systemCerebrospinal fluidSARS-CoV-2info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/50550/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALInflammatory_Otavio_Espindola_etal_INI_2021.pdfInflammatory_Otavio_Espindola_etal_INI_2021.pdfapplication/pdf812220https://www.arca.fiocruz.br/bitstream/icict/50550/2/Inflammatory_Otavio_Espindola_etal_INI_2021.pdf08672dd4b4139bb270d02a58235ebcc6MD52icict/505502023-02-25 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| dc.title.pt_BR.fl_str_mv |
Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019 |
| title |
Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019 |
| spellingShingle |
Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019 Espíndola, Otávio M. COVID-19 Inflammatory neurological diseases Central nervous system Cerebrospinal fluid SARS-CoV-2 |
| title_short |
Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019 |
| title_full |
Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019 |
| title_fullStr |
Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019 |
| title_full_unstemmed |
Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019 |
| title_sort |
Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019 |
| author |
Espíndola, Otávio M. |
| author_facet |
Espíndola, Otávio M. Gomes, Yago C. P. Brandão, Carlos Otávio Torres, Rafael C. Siqueira, Marilda Agudo Mendonça Teixeira de Soares, Cristiane N. Lima, Marco Antonio S. D. Leite, Ana Claudia C. B. Venturotti, Carolina O. Carvalho, Ana Julia C. Torezani, Guilherme Araujo, Abelardo Q. C. Silva, Marcus Tulius T. |
| author_role |
author |
| author2 |
Gomes, Yago C. P. Brandão, Carlos Otávio Torres, Rafael C. Siqueira, Marilda Agudo Mendonça Teixeira de Soares, Cristiane N. Lima, Marco Antonio S. D. Leite, Ana Claudia C. B. Venturotti, Carolina O. Carvalho, Ana Julia C. Torezani, Guilherme Araujo, Abelardo Q. C. Silva, Marcus Tulius T. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Espíndola, Otávio M. Gomes, Yago C. P. Brandão, Carlos Otávio Torres, Rafael C. Siqueira, Marilda Agudo Mendonça Teixeira de Soares, Cristiane N. Lima, Marco Antonio S. D. Leite, Ana Claudia C. B. Venturotti, Carolina O. Carvalho, Ana Julia C. Torezani, Guilherme Araujo, Abelardo Q. C. Silva, Marcus Tulius T. |
| dc.subject.en.pt_BR.fl_str_mv |
COVID-19 Inflammatory neurological diseases Central nervous system Cerebrospinal fluid SARS-CoV-2 |
| topic |
COVID-19 Inflammatory neurological diseases Central nervous system Cerebrospinal fluid SARS-CoV-2 |
| description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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2021 |
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2021-12-29T00:11:59Z |
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2021-12-29T00:11:59Z |
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2021 |
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Espíndola, Otávio M. et al. Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019. Annals of Neurology, v. 89, n. 5, p. 1041-1045, 2021. |
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https://www.arca.fiocruz.br/handle/icict/50550 |
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0364-5134 |
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10.1002/ana.26041 |
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Espíndola, Otávio M. et al. Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019. Annals of Neurology, v. 89, n. 5, p. 1041-1045, 2021. 0364-5134 10.1002/ana.26041 |
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