Epidemic history of major genotypes of hepatitis C virus in Uruguay

Detalhes bibliográficos
Autor(a) principal: Castells, M.
Data de Publicação: 2015
Outros Autores: Bello, G., Ifrán, S., Pereyra, S., Boschi, S., Uriarte, R., Cristina, J., Colina, R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12001
Resumo: Jun. 2016
id CRUZ_4ff67affe72983eccc464e08bb9b4467
oai_identifier_str oai:www.arca.fiocruz.br:icict/12001
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Castells, M.Bello, G.Ifrán, S.Pereyra, S.Boschi, S.Uriarte, R.Cristina, J.Colina, R.2015-10-20T15:04:59Z2015CASTELLS, M. et al. Epidemic history of major genotypes of hepatitis C virus in Uruguay. Infection, Genetics and Evolution, v. 32, p. 231-238, June 2015.1567-134810.1016/j.meegid.2015.03.021https://www.arca.fiocruz.br/handle/icict/12001engElsevierHepatite CHistóriaEvoluçãoUruguaiHepatitis CHistoryReconstructionCladesEvolutionUruguayHepatite CEpidemic history of major genotypes of hepatitis C virus in Uruguayinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJun. 20162015-12-31Universidad de la República. Centro Universitario de la Regional Noroeste. Laboratorio de Virología Molecular, Regional Norte. Salto, Uruguay.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de AIDS & Inmunología Molecular. Rio de Janeiro, RJ, Brasil.Asociación Española Primera de Socorros Mutuos. Laboratorio de Biología Molecular. Montevideo, Uruguay.Asociación Española Primera de Socorros Mutuos. Laboratorio de Biología Molecular. Montevideo, Uruguay.Asociación Española Primera de Socorros Mutuos. Laboratorio de Biología Molecular. Montevideo, Uruguay.Asociación Española Primera de Socorros Mutuos. Laboratorio de Biología Molecular. Montevideo, Uruguay.Universidad de la República. Facultad de Ciencias. Centro de Investigaciones Nucleares. Laboratorio de Virología Molecular. Montevideo, Uruguay.Universidad de la República. Centro Universitario de la Regional Noroeste. Laboratorio de Virología Molecular, Regional Norte. Salto, Uruguay.Worldwide, more than 170 million people are chronically infected with the hepatitis C virus (HCV) and every year die more than 350,000 people from HCV-related liver diseases. Recently, HCV was reclassified into seven major genotypes and 67 subtypes. Some subtypes as 1a, 1b and 3a, have become epidemic as a result of the new parenteral transmission routes and are responsible for most HCV infections in Western countries. HCV 1a subtype have been sub-categorized into two separate sub clades. Recent studies based on the analysis of NS5B genome region, reveal that HCV epidemics in Argentina and Brazil are characterized by multiple introductions events of subtypes 1a, 1b and 3a, followed by subsequent local dispersion. There is no data about HCV genotypes circulating in Uruguay and their evolutionary and demographic history. To this end, a total of 153 HCV NS5B gene sequences were obtained from Uruguayan patients between 2005 and 2011. 86 (56%) sequences grouped with subtype 1a, 40 (26%) with subtype 3a and 27 (18%) with subtype 1b. Furthermore, subtype 1a sequences were distributed among both clades, 1 (n = 62, 72%) and 2 (n = 24, 28%). Four local HCV clades were found: UY-1a(I), UY-1a(II), UY-1a(III) and UY-3a; comprising a 39% of all HCV viruses analyzed in this study. HCV epidemic in Uruguay has been driving by multiple introductions of subtypes 1a, 1b and 3a and by local dissemination of a few country-specific strains. The evolutionary and demographic history of the major Uruguayan HCV clade UY-1a(I) was reconstructed under two different molecular clock rate models and displayed an epidemic history characterized by an initial phase of rapid expansion followed by a more recent reduction of growth rate since 2000–2005. This is the first comprehensive study about the molecular epidemiology and epidemic history of HCV in Uruguay.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/12001/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALg_bello_etal_IOC_2015.pdfg_bello_etal_IOC_2015.pdfapplication/pdf2243670https://www.arca.fiocruz.br/bitstream/icict/12001/2/g_bello_etal_IOC_2015.pdfe65f347c1b80bd5717095fc4ee64c2feMD52TEXTg_bello_etal_IOC_2015.pdf.txtg_bello_etal_IOC_2015.pdf.txtExtracted texttext/plain33623https://www.arca.fiocruz.br/bitstream/icict/12001/3/g_bello_etal_IOC_2015.pdf.txteb58dd1fe15b256b755e3f974528e5abMD53icict/120012021-03-24 16:32:18.249oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Epidemic history of major genotypes of hepatitis C virus in Uruguay
title Epidemic history of major genotypes of hepatitis C virus in Uruguay
spellingShingle Epidemic history of major genotypes of hepatitis C virus in Uruguay
Castells, M.
Hepatite C
História
Evolução
Uruguai
Hepatitis C
History
Reconstruction
Clades
Evolution
Uruguay
Hepatite C
title_short Epidemic history of major genotypes of hepatitis C virus in Uruguay
title_full Epidemic history of major genotypes of hepatitis C virus in Uruguay
title_fullStr Epidemic history of major genotypes of hepatitis C virus in Uruguay
title_full_unstemmed Epidemic history of major genotypes of hepatitis C virus in Uruguay
title_sort Epidemic history of major genotypes of hepatitis C virus in Uruguay
author Castells, M.
author_facet Castells, M.
Bello, G.
Ifrán, S.
Pereyra, S.
Boschi, S.
Uriarte, R.
Cristina, J.
Colina, R.
author_role author
author2 Bello, G.
Ifrán, S.
Pereyra, S.
Boschi, S.
Uriarte, R.
Cristina, J.
Colina, R.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castells, M.
Bello, G.
Ifrán, S.
Pereyra, S.
Boschi, S.
Uriarte, R.
Cristina, J.
Colina, R.
dc.subject.other.pt_BR.fl_str_mv Hepatite C
História
Evolução
Uruguai
topic Hepatite C
História
Evolução
Uruguai
Hepatitis C
History
Reconstruction
Clades
Evolution
Uruguay
Hepatite C
dc.subject.en.pt_BR.fl_str_mv Hepatitis C
History
Reconstruction
Clades
Evolution
Uruguay
dc.subject.decs.pt_BR.fl_str_mv Hepatite C
description Jun. 2016
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-10-20T15:04:59Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CASTELLS, M. et al. Epidemic history of major genotypes of hepatitis C virus in Uruguay. Infection, Genetics and Evolution, v. 32, p. 231-238, June 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12001
dc.identifier.issn.none.fl_str_mv 1567-1348
10.1016/j.meegid.2015.03.021
identifier_str_mv CASTELLS, M. et al. Epidemic history of major genotypes of hepatitis C virus in Uruguay. Infection, Genetics and Evolution, v. 32, p. 231-238, June 2015.
1567-1348
10.1016/j.meegid.2015.03.021
url https://www.arca.fiocruz.br/handle/icict/12001
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/12001/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/12001/2/g_bello_etal_IOC_2015.pdf
https://www.arca.fiocruz.br/bitstream/icict/12001/3/g_bello_etal_IOC_2015.pdf.txt
bitstream.checksum.fl_str_mv 8b4c200b4e10021c5683c6ccaba07169
e65f347c1b80bd5717095fc4ee64c2fe
eb58dd1fe15b256b755e3f974528e5ab
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009170574606336

Registros relacionados