Phenotypic characteristics associated with virulence of clinical isolates from the Sporothrix complex

Detalhes bibliográficos
Autor(a) principal: Almeida-Paes, Rodrigo
Data de Publicação: 2015
Outros Autores: Oliveira, Luã Cardoso de, Oliveira, Manoel Marques Evangelista, Gutierrez-Galhardo, Maria Clara, Nosanchuk, Joshua Daniel, Zancopé-Oliveira, Rosely Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31996
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
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spelling Almeida-Paes, RodrigoOliveira, Luã Cardoso deOliveira, Manoel Marques EvangelistaGutierrez-Galhardo, Maria ClaraNosanchuk, Joshua DanielZancopé-Oliveira, Rosely Maria2019-03-08T12:53:49Z2019-03-08T12:53:49Z2015ALMEIDA-PAES, Rodrigo et al. Phenotypic characteristics associated with virulence of clinical isolates from the Sporothrix complex. Biomed Research International, v. 2015, p. 1-11, 2015.2314-6133https://www.arca.fiocruz.br/handle/icict/3199610.1155/2015/2123082314-6133engHindawi Publishing CorporationPhenotypic characteristics associated with virulence of clinical isolates from the Sporothrix complexinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Dermatologia Infecciosa. Rio de Janeiro, RJ, BrazilAlbert Einstein College of Medicine. Department of Medicine. Division of Infectious Diseases. New York, NY, USA / Albert Einstein College of Medicine. Department of Microbiology and Immunology. New York, NY, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.The Sporothrix complex members cause sporotrichosis, a subcutaneous mycosis with a wide spectrum of clinical manifestations. Several specific phenotypic characteristics are associated with virulence in many fungi, but studies in this field involving the Sporothrix complex species are scarce. Melanization, thermotolerance, and production of proteases, catalase, and urease were investigated in 61 S. brasiliensis, one S. globosa, and 10 S. schenckii strains. The S. brasiliensis strains showed a higher expression of melanin and urease compared with S. schenckii. These two species, however, presented similar thermotolerances. Our S. globosa strain had low expression of all studied virulence factors. The relationship between these phenotypes and clinical aspects of sporotrichosis was also evaluated. Strains isolated from patients with spontaneous regression of infection were heavily melanized and produced high urease levels. Melanin was also related to dissemination of internal organs and protease production was associated with HIV-coinfection. A murine sporotrichosis model showed that a S. brasiliensis strain with high expression of virulence factors was able to disseminate and yield a high fungal burden in comparison with a control S. schenckii strain. Our results show that virulence-related phenotypes are variably expressed within the Sporothrix complex species and might be involved in clinical aspects of sporotrichosis.Sporothrix complexVirulence of clinical isolatesPhenotypic characteristicsSporotrichosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31996/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Almeida-Paes_Rodrigo_etal_INI_2015.pdfve_Almeida-Paes_Rodrigo_etal_INI_2015.pdfapplication/pdf1587045https://www.arca.fiocruz.br/bitstream/icict/31996/2/ve_Almeida-Paes_Rodrigo_etal_INI_2015.pdf0cf5fed310ee11f1342876292f9c356eMD52TEXTve_Almeida-Paes_Rodrigo_etal_INI_2015.pdf.txtve_Almeida-Paes_Rodrigo_etal_INI_2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Phenotypic characteristics associated with virulence of clinical isolates from the Sporothrix complex
title Phenotypic characteristics associated with virulence of clinical isolates from the Sporothrix complex
spellingShingle Phenotypic characteristics associated with virulence of clinical isolates from the Sporothrix complex
Almeida-Paes, Rodrigo
Sporothrix complex
Virulence of clinical isolates
Phenotypic characteristics
Sporotrichosis
title_short Phenotypic characteristics associated with virulence of clinical isolates from the Sporothrix complex
title_full Phenotypic characteristics associated with virulence of clinical isolates from the Sporothrix complex
title_fullStr Phenotypic characteristics associated with virulence of clinical isolates from the Sporothrix complex
title_full_unstemmed Phenotypic characteristics associated with virulence of clinical isolates from the Sporothrix complex
title_sort Phenotypic characteristics associated with virulence of clinical isolates from the Sporothrix complex
author Almeida-Paes, Rodrigo
author_facet Almeida-Paes, Rodrigo
Oliveira, Luã Cardoso de
Oliveira, Manoel Marques Evangelista
Gutierrez-Galhardo, Maria Clara
Nosanchuk, Joshua Daniel
Zancopé-Oliveira, Rosely Maria
author_role author
author2 Oliveira, Luã Cardoso de
Oliveira, Manoel Marques Evangelista
Gutierrez-Galhardo, Maria Clara
Nosanchuk, Joshua Daniel
Zancopé-Oliveira, Rosely Maria
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida-Paes, Rodrigo
Oliveira, Luã Cardoso de
Oliveira, Manoel Marques Evangelista
Gutierrez-Galhardo, Maria Clara
Nosanchuk, Joshua Daniel
Zancopé-Oliveira, Rosely Maria
dc.subject.en.pt_BR.fl_str_mv Sporothrix complex
Virulence of clinical isolates
Phenotypic characteristics
Sporotrichosis
topic Sporothrix complex
Virulence of clinical isolates
Phenotypic characteristics
Sporotrichosis
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-03-08T12:53:49Z
dc.date.available.fl_str_mv 2019-03-08T12:53:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA-PAES, Rodrigo et al. Phenotypic characteristics associated with virulence of clinical isolates from the Sporothrix complex. Biomed Research International, v. 2015, p. 1-11, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31996
dc.identifier.issn.pt_BR.fl_str_mv 2314-6133
dc.identifier.doi.none.fl_str_mv 10.1155/2015/212308
dc.identifier.eissn.none.fl_str_mv 2314-6133
identifier_str_mv ALMEIDA-PAES, Rodrigo et al. Phenotypic characteristics associated with virulence of clinical isolates from the Sporothrix complex. Biomed Research International, v. 2015, p. 1-11, 2015.
2314-6133
10.1155/2015/212308
url https://www.arca.fiocruz.br/handle/icict/31996
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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