Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/49287 |
Resumo: | Fundação Oswaldo Cruz. Insituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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Solórzano, Victor Edgar FiestasFaria, Nieli Rodrigues da CostaSantos, Caroline Fernandes dosCorrêa, GladysCipitelli, Márcio da CostaRibeiro, Marcos DornelasSouza, Luiz José deDamasco, Paulo VieiraCunha, Rivaldo Venâncio daSantos, Flavia Barreto dosPinto, Luzia Maria de OliveiraAzeredo, Elzinandes Leal de2021-10-06T10:23:44Z2021-10-06T10:23:44Z2021SOLÓRZANO, Victor Edgar Fiestas et al. Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus. Viruses, v. 13, 1789, 16 p, Sept. 2021.1999-4915https://www.arca.fiocruz.br/handle/icict/4928710.3390/v13091789engMDPIDengueBrasilBiomarcadoresAnálise de componentes principaisDenguePrincipal component analysisBiomarkersBrazilDifferent Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Insituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Insituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Insituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Insituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Instituto de Biologia do Exército. Laboratório de Biologia Molecular. Rio de Janeiro, RJ, Brasil.Instituto de Biologia do Exército. Laboratório de Biologia Molecular. Rio de Janeiro, RJ, Brasil.Centro de Referência de Doenças Imuno-Infecciosas. Campos dos Goytacazes, RJ, Brasil / Faculdade de Medicina de Campos. Departamento de Clínica Médica. Campos dos Goytacazes, RJ, Brasil.Rede Casa Hospital Rio Laranjeiras. Rio de janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Escola de Medicina e Cirurgia. Rio de Janeiro, RJ, Brasil..Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Insituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Insituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Insituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile of cytokines (IFN- , TNF- , IL-1 , IL-6, IL-18 and IL-10), chemokines (CXCL8/IL-8, CCL2/MCP-1 and CXCL10/IP-10) and coagulation mediators (Fibrinogen, D-dimer, Tissue factor-TF, Tissue factor pathway inhibitor-TFPI and Thrombomodulin) during the dengue-4 epidemic in Brazil. Laboratory-confirmed dengue cases had higher levels of TNF- (p < 0.001), IL-6 (p = 0.005), IL-10 (p < 0.001), IL-18 (p = 0.001), CXCL8/IL-8 (p < 0.001), CCL2/MCP-1 (p < 0.001), CXCL10/IP-10 (p = 0.001), fibrinogen (p = 0.037), D-dimer (p = 0.01) and TFPI (p = 0.042) and lower levels of TF (p = 0.042) compared to healthy controls. A principal component analysis (PCA) distinguished between two profiles of mediators of inflammation and coagulation: protective (TNF- , IL-1 and CXCL8/IL-8) and pathological (IL-6, TF and TFPI). Lastly, multivariate logistic regression analysis identified high aspartate aminotransferaseto- platelet ratio index (APRI) as independent risk factors associated with severity (adjusted OR: 1.33; 95% CI 1.03–1.71; p = 0.027), the area under the receiver operating characteristics curve (AUC) was 0.775 (95% CI 0.681–0.869) and an optimal cutoff value was 1.4 (sensitivity: 76%; specificity: 79%), so it could be a useful marker for the triage of patients attending primary care centers.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/49287/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVictorSolozano_FlaviaBSantos_etal_IOC_2021.pdfVictorSolozano_FlaviaBSantos_etal_IOC_2021.pdfapplication/pdf995498https://www.arca.fiocruz.br/bitstream/icict/49287/2/VictorSolozano_FlaviaBSantos_etal_IOC_2021.pdf8b5b6b1861a059467536e608d064dbd2MD52icict/492872021-10-06 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| dc.title.pt_BR.fl_str_mv |
Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus |
| title |
Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus |
| spellingShingle |
Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus Solórzano, Victor Edgar Fiestas Dengue Brasil Biomarcadores Análise de componentes principais Dengue Principal component analysis Biomarkers Brazil |
| title_short |
Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus |
| title_full |
Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus |
| title_fullStr |
Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus |
| title_full_unstemmed |
Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus |
| title_sort |
Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus |
| author |
Solórzano, Victor Edgar Fiestas |
| author_facet |
Solórzano, Victor Edgar Fiestas Faria, Nieli Rodrigues da Costa Santos, Caroline Fernandes dos Corrêa, Gladys Cipitelli, Márcio da Costa Ribeiro, Marcos Dornelas Souza, Luiz José de Damasco, Paulo Vieira Cunha, Rivaldo Venâncio da Santos, Flavia Barreto dos Pinto, Luzia Maria de Oliveira Azeredo, Elzinandes Leal de |
| author_role |
author |
| author2 |
Faria, Nieli Rodrigues da Costa Santos, Caroline Fernandes dos Corrêa, Gladys Cipitelli, Márcio da Costa Ribeiro, Marcos Dornelas Souza, Luiz José de Damasco, Paulo Vieira Cunha, Rivaldo Venâncio da Santos, Flavia Barreto dos Pinto, Luzia Maria de Oliveira Azeredo, Elzinandes Leal de |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Solórzano, Victor Edgar Fiestas Faria, Nieli Rodrigues da Costa Santos, Caroline Fernandes dos Corrêa, Gladys Cipitelli, Márcio da Costa Ribeiro, Marcos Dornelas Souza, Luiz José de Damasco, Paulo Vieira Cunha, Rivaldo Venâncio da Santos, Flavia Barreto dos Pinto, Luzia Maria de Oliveira Azeredo, Elzinandes Leal de |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Brasil Biomarcadores Análise de componentes principais |
| topic |
Dengue Brasil Biomarcadores Análise de componentes principais Dengue Principal component analysis Biomarkers Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
Dengue Principal component analysis Biomarkers Brazil |
| description |
Fundação Oswaldo Cruz. Insituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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2021 |
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2021-10-06T10:23:44Z |
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2021-10-06T10:23:44Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SOLÓRZANO, Victor Edgar Fiestas et al. Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus. Viruses, v. 13, 1789, 16 p, Sept. 2021. |
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https://www.arca.fiocruz.br/handle/icict/49287 |
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1999-4915 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/v13091789 |
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SOLÓRZANO, Victor Edgar Fiestas et al. Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus. Viruses, v. 13, 1789, 16 p, Sept. 2021. 1999-4915 10.3390/v13091789 |
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