Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels

Detalhes bibliográficos
Autor(a) principal: Salles, Fernanda
Data de Publicação: 2013
Outros Autores: Bacellar, Andrea, Amorim, Mirla, Orge, Glória, Sundberg, Michael, Lima, Márcia, Santos, Silvane, Porto, Aurélia, Carvalho Filho, Edgar Marcelino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/26915
Resumo: Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Salles, FernandaBacellar, AndreaAmorim, MirlaOrge, GlóriaSundberg, MichaelLima, MárciaSantos, SilvanePorto, AuréliaCarvalho Filho, Edgar Marcelino2018-06-15T18:41:33Z2018-06-15T18:41:33Z2013SALLES, F. et al. Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels. Transactions of The Royal Society of Tropical Medicine and Hygiene, v. 107, p. 526–529, 2013.0035-9203https://www.arca.fiocruz.br/handle/icict/2691510.1093/trstmh/trt052Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.NIH Grants AI-079238, and the Brazilian National Research Council (CNPq); Fundação de Amparo a Pesquisa do Estado da Bahia. EC is a senior investigator with CNPq.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilStanford University School of Medicine. Stanford, CA, USAUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal de Sergipe. Faculdade de Medicina. Aracaju, SE, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilHuman T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL). Methods:We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection. Results: Levels of TNFa and IFNg were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p , 0.05), and there was an increase in TNFa levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p,0.05). The one patient who developed ATLLwas coinfected with S. stercoralis. Conclusion: These data showthat helminthic infection has a modulatory role inHTLV-1 infection and that S. stercoralis may be a cofactor in the development ofATLL.engOxford University PressHTLV-1Strongyloides stercoralisLeucemiaATLLReceptor de interleucina-2sIL-2RHTLV-1Strongyloides stercoralisLeukemiaATLLInterleukin-2 receptorsIL-2RTreatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levelsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26915/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSalles F Treatment....pdfSalles F 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dc.title.pt_BR.fl_str_mv Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels
title Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels
spellingShingle Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels
Salles, Fernanda
HTLV-1
Strongyloides stercoralis
Leucemia
ATLL
Receptor de interleucina-2
sIL-2R
HTLV-1
Strongyloides stercoralis
Leukemia
ATLL
Interleukin-2 receptor
sIL-2R
title_short Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels
title_full Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels
title_fullStr Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels
title_full_unstemmed Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels
title_sort Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels
author Salles, Fernanda
author_facet Salles, Fernanda
Bacellar, Andrea
Amorim, Mirla
Orge, Glória
Sundberg, Michael
Lima, Márcia
Santos, Silvane
Porto, Aurélia
Carvalho Filho, Edgar Marcelino
author_role author
author2 Bacellar, Andrea
Amorim, Mirla
Orge, Glória
Sundberg, Michael
Lima, Márcia
Santos, Silvane
Porto, Aurélia
Carvalho Filho, Edgar Marcelino
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Salles, Fernanda
Bacellar, Andrea
Amorim, Mirla
Orge, Glória
Sundberg, Michael
Lima, Márcia
Santos, Silvane
Porto, Aurélia
Carvalho Filho, Edgar Marcelino
dc.subject.other.pt_BR.fl_str_mv HTLV-1
Strongyloides stercoralis
Leucemia
ATLL
Receptor de interleucina-2
sIL-2R
topic HTLV-1
Strongyloides stercoralis
Leucemia
ATLL
Receptor de interleucina-2
sIL-2R
HTLV-1
Strongyloides stercoralis
Leukemia
ATLL
Interleukin-2 receptor
sIL-2R
dc.subject.en.pt_BR.fl_str_mv HTLV-1
Strongyloides stercoralis
Leukemia
ATLL
Interleukin-2 receptor
sIL-2R
description Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2018-06-15T18:41:33Z
dc.date.available.fl_str_mv 2018-06-15T18:41:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SALLES, F. et al. Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels. Transactions of The Royal Society of Tropical Medicine and Hygiene, v. 107, p. 526–529, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/26915
dc.identifier.issn.pt_BR.fl_str_mv 0035-9203
dc.identifier.doi.none.fl_str_mv 10.1093/trstmh/trt052
identifier_str_mv SALLES, F. et al. Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels. Transactions of The Royal Society of Tropical Medicine and Hygiene, v. 107, p. 526–529, 2013.
0035-9203
10.1093/trstmh/trt052
url https://www.arca.fiocruz.br/handle/icict/26915
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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