Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction

Detalhes bibliográficos
Autor(a) principal: Menezes, Ana Paula de Oliveira
Data de Publicação: 2016
Outros Autores: Azevedo, Jailton, Leite, Mariela C, Campos, Leila Carvalho, Cunha, Marcelo, Carvalho, Maria da Gloria S, Reis, Mitermayer Galvão dos, Ko, Albert Icksang, Weinberger, Daniel M, Ribeiro, Guilherme de Sousa, Reis, Joice Neves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13029
Resumo: Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Menezes, Ana Paula de OliveiraAzevedo, JailtonLeite, Mariela CCampos, Leila CarvalhoCunha, MarceloCarvalho, Maria da Gloria SReis, Mitermayer Galvão dosKo, Albert IcksangWeinberger, Daniel MRibeiro, Guilherme de SousaReis, Joice Neves2016-03-04T18:58:18Z2016-03-04T18:58:18Z2016MENEZES, A. P. O. Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction. Vaccine, v. 34, n. 6, p. 791-797, 2016.0264-410Xdx.doi.org/10.1016/j.vaccine.2015.12.042https://www.arca.fiocruz.br/handle/icict/13029engElsevierNasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introductioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Rio de Janeiro, RJ, BrasilCenters for Disease Control & Prevention. Respiratory Diseases Branch. Atlanta, GA, USAFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, USAYale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, USAFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasiltInformation on pneumococcal carriage in the pre-vaccine period is essential to predict and assess theimpact of PCV in settings where disease surveillance is particularly difficult. Therefore, we present dataon pneumococcal carriage before the introduction of the 10-valent-pneumococcal conjugate vaccine(PCV10) in Brazil. We conducted a prospective study on a cohort of 203 children aged <5 years old,randomly selected in an urban community located in the periphery of the city of Salvador, Brazil andfollowed them from January/2008 to January/2009. Nasopharyngeal swabs were collected from eachchild at four times. In total, 721 swabs were collected, yielding a pneumococcal carriage prevalence of55% (n = 398). In multivariate analyses, the variables associated with carriage were having contact withthree or more children <2 years old (OR, 2.00; 95% CI 1.33–2.89) and living in a house with an averageof 3 residents per room (OR, 1.77; 95% CI 1.05–3.10). Also, white participants were more likely to beprotected from colonization (OR, 0.52; 95% CI 0.29–0.93), and prevalence of carriage varied over time,with lower prevalence occurring from February to June (OR, 0.53; 95% CI 0.37–0.78) compared to Julyto January. Contact with children under 2 years of age and living in crowded housing also were associ-ated with colonization by highly invasive serotypes, although this relationship was not significant. Themost prevalent vaccine serotypes were 6A/B (25.4%), 19F (10.1%) and 14 (9.0%), while the most preva-lent non-vaccine serotypes were 16F (4.8%), 15B/C (4.5%) and 6C/D (3.5%). Overall, 38.4% (153/398) ofthe isolates were non-susceptible to penicillin, and of those, 73.8% (113/153) were non-susceptible totrimethoprim/sulfamethoxazole. Colonization rate by PCV10 serotypes was 52.2%. Routine PCV10 vacci-nation can lead to significant changes in pneumococcal serotypes found in NP colonization, indicating aneed for continued monitoring, especially in crowded settings, as occurs in Brazil’s slums.ChildrenNasopharyngeal carriageStreptococcus pneumoniaeSerotypesPCV10-vaccineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13029/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMenezes AP O Nasopharyngeal....pdfMenezes AP O Nasopharyngeal....pdfapplication/pdf316395https://www.arca.fiocruz.br/bitstream/icict/13029/2/Menezes%20AP%20O%20Nasopharyngeal....pdfd4b451e6a927e8a1a9090cba0fe42936MD52TEXTMenezes AP O Nasopharyngeal....pdf.txtMenezes AP O Nasopharyngeal....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction
title Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction
spellingShingle Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction
Menezes, Ana Paula de Oliveira
Children
Nasopharyngeal carriage
Streptococcus pneumoniae
Serotypes
PCV10-vaccine
title_short Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction
title_full Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction
title_fullStr Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction
title_full_unstemmed Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction
title_sort Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction
author Menezes, Ana Paula de Oliveira
author_facet Menezes, Ana Paula de Oliveira
Azevedo, Jailton
Leite, Mariela C
Campos, Leila Carvalho
Cunha, Marcelo
Carvalho, Maria da Gloria S
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Weinberger, Daniel M
Ribeiro, Guilherme de Sousa
Reis, Joice Neves
author_role author
author2 Azevedo, Jailton
Leite, Mariela C
Campos, Leila Carvalho
Cunha, Marcelo
Carvalho, Maria da Gloria S
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Weinberger, Daniel M
Ribeiro, Guilherme de Sousa
Reis, Joice Neves
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Menezes, Ana Paula de Oliveira
Azevedo, Jailton
Leite, Mariela C
Campos, Leila Carvalho
Cunha, Marcelo
Carvalho, Maria da Gloria S
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Weinberger, Daniel M
Ribeiro, Guilherme de Sousa
Reis, Joice Neves
dc.subject.en.pt_BR.fl_str_mv Children
Nasopharyngeal carriage
Streptococcus pneumoniae
Serotypes
PCV10-vaccine
topic Children
Nasopharyngeal carriage
Streptococcus pneumoniae
Serotypes
PCV10-vaccine
description Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-03-04T18:58:18Z
dc.date.available.fl_str_mv 2016-03-04T18:58:18Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MENEZES, A. P. O. Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction. Vaccine, v. 34, n. 6, p. 791-797, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13029
dc.identifier.issn.none.fl_str_mv 0264-410X
dx.doi.org/10.1016/j.vaccine.2015.12.042
identifier_str_mv MENEZES, A. P. O. Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction. Vaccine, v. 34, n. 6, p. 791-797, 2016.
0264-410X
dx.doi.org/10.1016/j.vaccine.2015.12.042
url https://www.arca.fiocruz.br/handle/icict/13029
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/13029/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/13029/3/Menezes%20AP%20O%20Nasopharyngeal....pdf.txt
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