Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients

Detalhes bibliográficos
Autor(a) principal: Corrêa, Jôice Dias
Data de Publicação: 2019
Outros Autores: Fernandes, Gabriel da Rocha, Calderaro, Débora Cerqueira, Mendonça, Santuza Maria Souza, Silva, Janine Mayra, Albiero, Mayra Laino, Cunha, Fernando Q., Xiao, E., Ferreira, Gilda Aparecida, Teixeira, Antônio Lúcio, Mukherjee, Chiranjit, Leys, Eugene J., Silva, Tarcília Aparecida, Graves, Dana T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34926
Resumo: 2020-01-01
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spelling Corrêa, Jôice DiasFernandes, Gabriel da RochaCalderaro, Débora CerqueiraMendonça, Santuza Maria SouzaSilva, Janine MayraAlbiero, Mayra LainoCunha, Fernando Q.Xiao, E.Ferreira, Gilda AparecidaTeixeira, Antônio LúcioMukherjee, ChiranjitLeys, Eugene J.Silva, Tarcília AparecidaGraves, Dana T.2019-08-21T14:15:41Z2019-08-21T14:15:41Z2019CORRÊA, Jôice Dias et al. Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients. Sci Rep., v. 9, n. 1, 8379, 20192045-2322https://www.arca.fiocruz.br/handle/icict/3492610.1038/s41598-019-44674-6engNature Publishing GroupOral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Universidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG BrazilUniversidade Federal de Minas Gerais. Hospital Universitário. Belo Horizonte, MG BrazilUniversidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG BrazilUniversidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG BrazilUniversidade de Campinas. Faculdade de Odontologia. Piracicaba, SP BrazilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP BrazilPenn Dental School. University of Pennsylvania. Philadelphia, PA USAUniversidade Federal de Minas Gerais. Hospital Universitário. Belo Horizonte, MG BrazilUniversidade Federal de Minas Gerais. Hospital Universitário. Belo Horizonte, MG BrazilThe Ohio State University. College of Dentistry. Columbus, OH USAThe Ohio State University. College of Dentistry. Columbus, OH USAUniversidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG BrazilPenn Dental School. University of Pennsylvania. Philadelphia, PA USARheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. Individuals with RA have a higher risk of periodontitis and periodontitis has been linked to RA through the production of enzymes by periodontal pathogens that citrullinate proteins. This linkage is supported by findings that periodontitis is associated with increased RA severity and treatment of periodontitis can improve the symptoms of RA. The possible mechanism for this association is through dysbiosis of the oral microbiota triggered by RA-induced systemic inflammation. We examined the RA status of subjects by measuring the number of tender and swollen joints, anti-citrullinated protein antibody and rheumatoid factor. Periodontal disease status and salivary cytokine levels were measured, and dental plaque analyzed by 16S rRNA high throughput sequencing. RA patients had a higher bacterial load, a more diverse microbiota, an increase in bacterial species associated with periodontal disease, more clinical attachment loss, and increased production of inflammatory mediators including IL-17, IL-2, TNF, and IFN-γ. Furthermore, changes in the oral microbiota were linked to worse RA conditions. Our study provides new insights into the bi-directional relationship between periodontitis and RA and suggest that monitoring the periodontal health of RA patients is particularly important.Rheumatoid arthritisMicrobiologyPeriodonticsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/34926/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALOral microbial dysbiosis linked.pdfOral microbial dysbiosis linked.pdfapplication/pdf1047172https://www.arca.fiocruz.br/bitstream/icict/34926/2/Oral%20microbial%20dysbiosis%20linked.pdfc5840c88425350c4bb2be06a733497f1MD52TEXTOral microbial dysbiosis linked.pdf.txtOral microbial dysbiosis linked.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients
title Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients
spellingShingle Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients
Corrêa, Jôice Dias
Rheumatoid arthritis
Microbiology
Periodontics
title_short Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients
title_full Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients
title_fullStr Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients
title_full_unstemmed Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients
title_sort Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients
author Corrêa, Jôice Dias
author_facet Corrêa, Jôice Dias
Fernandes, Gabriel da Rocha
Calderaro, Débora Cerqueira
Mendonça, Santuza Maria Souza
Silva, Janine Mayra
Albiero, Mayra Laino
Cunha, Fernando Q.
Xiao, E.
Ferreira, Gilda Aparecida
Teixeira, Antônio Lúcio
Mukherjee, Chiranjit
Leys, Eugene J.
Silva, Tarcília Aparecida
Graves, Dana T.
author_role author
author2 Fernandes, Gabriel da Rocha
Calderaro, Débora Cerqueira
Mendonça, Santuza Maria Souza
Silva, Janine Mayra
Albiero, Mayra Laino
Cunha, Fernando Q.
Xiao, E.
Ferreira, Gilda Aparecida
Teixeira, Antônio Lúcio
Mukherjee, Chiranjit
Leys, Eugene J.
Silva, Tarcília Aparecida
Graves, Dana T.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Corrêa, Jôice Dias
Fernandes, Gabriel da Rocha
Calderaro, Débora Cerqueira
Mendonça, Santuza Maria Souza
Silva, Janine Mayra
Albiero, Mayra Laino
Cunha, Fernando Q.
Xiao, E.
Ferreira, Gilda Aparecida
Teixeira, Antônio Lúcio
Mukherjee, Chiranjit
Leys, Eugene J.
Silva, Tarcília Aparecida
Graves, Dana T.
dc.subject.en.pt_BR.fl_str_mv Rheumatoid arthritis
Microbiology
Periodontics
topic Rheumatoid arthritis
Microbiology
Periodontics
description 2020-01-01
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-08-21T14:15:41Z
dc.date.available.fl_str_mv 2019-08-21T14:15:41Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CORRÊA, Jôice Dias et al. Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients. Sci Rep., v. 9, n. 1, 8379, 2019
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34926
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-019-44674-6
identifier_str_mv CORRÊA, Jôice Dias et al. Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients. Sci Rep., v. 9, n. 1, 8379, 2019
2045-2322
10.1038/s41598-019-44674-6
url https://www.arca.fiocruz.br/handle/icict/34926
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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