Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28168 |
Resumo: | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB). |
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Pires, Anaque de OliveiraQueiroz, Gerson de AlmeidaSilva, Milca de JesusSilva, Raimon Rios daSilva, Hugo Bernardino Ferreira daCarneiro, Norma Vilany QueirozFonseca, Héllen FreitasSantana, Maria Borges Rabelo deNascimento, Regina SantosNeves, Neuza Maria AlcântaraCosta, Gustavo Nunes de OliveiraCosta, Ryan Dos SantosBarreto, Maurício LimaFigueiredo, Camila Alexandrina2018-08-16T11:59:43Z2018-08-16T11:59:43Z2018PIRES, A. O. et al. Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population. Molecular Immunology, v. 101, p. 294–302, 2018.0161-5890https://www.arca.fiocruz.br/handle/icict/2816810.1016/j.molimm.2018.07.014Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB).Federal University of Bahia. Laboratory of Immunopharmacology and Molecular Biology. Salvador, BA, BrazilFederal University of Bahia. Laboratory of Immunopharmacology and Molecular Biology. Salvador, BA, BrazilFederal University of Bahia. Laboratory of Immunopharmacology and Molecular Biology. Salvador, BA, BrazilFederal University of Bahia. Laboratory of Immunopharmacology and Molecular Biology. Salvador, BA, BrazilFederal University of Bahia. Laboratory of Immunopharmacology and Molecular Biology. Salvador, BA, BrazilFederal University of Bahia. Laboratory of Immunopharmacology and Molecular Biology. Salvador, BA, BrazilFederal University of Bahia. Laboratory of Immunopharmacology and Molecular Biology. Salvador, BA, BrazilFederal University of Bahia. Laboratory of Immunopharmacology and Molecular Biology. Salvador, BA, BrazilFederal University of Bahia. Laboratory of Immunopharmacology and Molecular Biology. Salvador, BA, BrazilFederal University of Bahia. Laboratory of Allergy and Acarology. Salvador, BA, BrazilFederal University of Bahia. Laboratory of Immunopharmacology and Molecular Biology. Salvador, BA, BrazilFederal University of Bahia. Laboratory of Immunopharmacology and Molecular Biology. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. Laboratory of Immunopharmacology and Molecular Biology. Salvador, BA, BrazilAtopic asthma, which is characterized by the chronic inflammation and morbidity of airways, is a disease of great complexity, and multiple genetic and environmental factors are involved in its etiology. In the first genome-wide association study (GWAS) conducted in Brazil for asthma, a positive association was found between atopic asthma and a variant (rs1999071), which is located between the DAD1 and OXA1L genes, although neither gene has previously been reported to be associated with asthma or allergies. The DAD1 gene is involved in the regulation of programmed cell death, and OXA1L is involved in biogenesis and mitochondrial oxidative phosphorylation. This study aimed to evaluate how polymorphisms in DAD1 and OXA1L are associated with asthma and markers of atopy in individuals from the Salvador cohort of the SCAALA (Social Change Asthma and Allergy in Latin America) program. The DNA of 1220 individuals was genotyped using the Illumina 2.5 Human Omni Bead chip. Logistic regression analyses were performed with PLINK 1.9 software to verify the association between DAD1 and OXA1L polymorphisms and asthma and atopic markers, adjusted for sex, age, helminth infections and ancestry markers, using an additive model. The DAD1 and OXA1L genes were associated with some of the evaluated phenotypes, such as asthma, skin prick test (SPT), specific IgE for aeroallergens, and Th1/Th2-type cytokine production. Using qPCR, as well as in silico gene expression analysis, we have demonstrated that some of the polymorphisms in both genes are able to affect their respective gene expression levels. In addition, DAD1 was over-expressed in asthmatic patients when compared with controls. Thus, our findings demonstrate that variants in both the DAD1 and OXA1L genes may affect atopy and asthma in a Latin American population with a high prevalence of asthma.engElsevierAsmaAlergiaPolimorfismosDAD1OXA1LAsthmaAllergyPolymorphismsDAD1OXA1LPolymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28168/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPires AO Polymorphisms in the DAD1 and OXA1L....pdfPires AO Polymorphisms in the DAD1 and 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| dc.title.pt_BR.fl_str_mv |
Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population |
| title |
Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population |
| spellingShingle |
Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population Pires, Anaque de Oliveira Asma Alergia Polimorfismos DAD1 OXA1L Asthma Allergy Polymorphisms DAD1 OXA1L |
| title_short |
Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population |
| title_full |
Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population |
| title_fullStr |
Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population |
| title_full_unstemmed |
Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population |
| title_sort |
Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population |
| author |
Pires, Anaque de Oliveira |
| author_facet |
Pires, Anaque de Oliveira Queiroz, Gerson de Almeida Silva, Milca de Jesus Silva, Raimon Rios da Silva, Hugo Bernardino Ferreira da Carneiro, Norma Vilany Queiroz Fonseca, Héllen Freitas Santana, Maria Borges Rabelo de Nascimento, Regina Santos Neves, Neuza Maria Alcântara Costa, Gustavo Nunes de Oliveira Costa, Ryan Dos Santos Barreto, Maurício Lima Figueiredo, Camila Alexandrina |
| author_role |
author |
| author2 |
Queiroz, Gerson de Almeida Silva, Milca de Jesus Silva, Raimon Rios da Silva, Hugo Bernardino Ferreira da Carneiro, Norma Vilany Queiroz Fonseca, Héllen Freitas Santana, Maria Borges Rabelo de Nascimento, Regina Santos Neves, Neuza Maria Alcântara Costa, Gustavo Nunes de Oliveira Costa, Ryan Dos Santos Barreto, Maurício Lima Figueiredo, Camila Alexandrina |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pires, Anaque de Oliveira Queiroz, Gerson de Almeida Silva, Milca de Jesus Silva, Raimon Rios da Silva, Hugo Bernardino Ferreira da Carneiro, Norma Vilany Queiroz Fonseca, Héllen Freitas Santana, Maria Borges Rabelo de Nascimento, Regina Santos Neves, Neuza Maria Alcântara Costa, Gustavo Nunes de Oliveira Costa, Ryan Dos Santos Barreto, Maurício Lima Figueiredo, Camila Alexandrina |
| dc.subject.other.pt_BR.fl_str_mv |
Asma Alergia Polimorfismos DAD1 OXA1L |
| topic |
Asma Alergia Polimorfismos DAD1 OXA1L Asthma Allergy Polymorphisms DAD1 OXA1L |
| dc.subject.en.pt_BR.fl_str_mv |
Asthma Allergy Polymorphisms DAD1 OXA1L |
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB). |
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2018 |
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2018-08-16T11:59:43Z |
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2018-08-16T11:59:43Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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publishedVersion |
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PIRES, A. O. et al. Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population. Molecular Immunology, v. 101, p. 294–302, 2018. |
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https://www.arca.fiocruz.br/handle/icict/28168 |
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0161-5890 |
| dc.identifier.eissn.none.fl_str_mv |
10.1016/j.molimm.2018.07.014 |
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PIRES, A. O. et al. Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population. Molecular Immunology, v. 101, p. 294–302, 2018. 0161-5890 10.1016/j.molimm.2018.07.014 |
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