Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients

Detalhes bibliográficos
Autor(a) principal: Arruda, Lucas Coelho Marlière
Data de Publicação: 2015
Outros Autores: Lorenzi, Julio Cesar Cetrulo, Sousa, A P A, Zanette, Dalila Lucíola, Palma, Patricia Vianna Bonini, Panepucci, Rodrigo Alexander, Souza, Doralina Guimarães Brum, Barreira, Amilton Antunes, Covas, Dimas Tadeu, Simões, Belinda Pinto, Silva Junior, Wilson Araújo da, Oliveira, Maria Carolina, Malmegrim, Kelen Cristina Ribeiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25071
Resumo: ZANETTE, Dalila Lucíola. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Arruda, Lucas Coelho MarlièreLorenzi, Julio Cesar CetruloSousa, A P AZanette, Dalila LucíolaPalma, Patricia Vianna BoniniPanepucci, Rodrigo AlexanderSouza, Doralina Guimarães BrumBarreira, Amilton AntunesCovas, Dimas TadeuSimões, Belinda PintoSilva Junior, Wilson Araújo daOliveira, Maria CarolinaMalmegrim, Kelen Cristina Ribeiro2018-03-06T15:34:01Z2018-03-06T15:34:01Z2015ARRUDA, L. C. M. et al. Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients. Bone Marrow Transplantation, v. 50, p. 380–389, 2015.0268-3369https://www.arca.fiocruz.br/handle/icict/2507110.1038/bmt.2014.277ZANETTE, Dalila Lucíola. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.CNPq and FAPESPUniversity of São Paulo. Ribeirão Preto Medical School. Regional Blood Center of Ribeirão Preto. Center for Cell-based Therapy. Ribeirão Preto, SP, Brazil / University of São Paulo. Ribeirão Preto Medical School. Department of Biochemistry and Immunology. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Regional Blood Center of Ribeirão Preto. Center for Cell-based Therapy. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Regional Blood Center of Ribeirão Preto. Center for Cell-based Therapy. Ribeirão Preto, SP, Brazil / Faculty of Medicine. Imperial College London. Division of Brain Sciences. London, UKUniversity of São Paulo. Ribeirão Preto Medical School. Regional Blood Center of Ribeirão Preto. Center for Cell-based Therapy. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Regional Blood Center of Ribeirão Preto. Center for Cell-based Therapy. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Regional Blood Center of Ribeirão Preto. Center for Cell-based Therapy. Ribeirão Preto, SP, Brazil / University of São Paulo. Ribeirão Preto Medical School. Division of Hematology. São Paulo, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Hospital das Clínicas. Department of Neuroscience and Behavioral Science. São Paulo, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Hospital das Clínicas. Department of Neuroscience and Behavioral Science. São Paulo, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Regional Blood Center of Ribeirão Preto. Center for Cell-based Therapy. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Regional Blood Center of Ribeirão Preto. Center for Cell-based Therapy. Ribeirão Preto, SP, Brazil / University of São Paulo. Ribeirão Preto Medical School. Department of Biochemistry and Immunology. Ribeirão Preto, SP, Brazil / University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Regional Blood Center of Ribeirão Preto. Center for Cell-based Therapy. Ribeirão Preto, SP, Brazil / University of São Paulo. Ribeirão Preto Medical School. Department of Biochemistry and Immunology. Ribeirão Preto, SP, Brazil / University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Regional Blood Center of Ribeirão Preto. Center for Cell-based Therapy. Ribeirão Preto, SP, Brazil / University of São Paulo. Ribeirão Preto Medical School. Department of Biochemistry and Immunology. Ribeirão Preto, SP, Brazil / University of São Paulo. Ribeirão Preto Medical School. Department of Internal Medicine. Ribeirão Preto, SP, BrazilUniversity of São Paulo. Ribeirão Preto Medical School. Regional Blood Center of Ribeirão Preto. Center for Cell-based Therapy. Ribeirão Preto, SP, Brazil / University of São Paulo. Ribeirão Preto Medical School. Department of Biochemistry and Immunology. Ribeirão Preto, SP, Brazil / University of São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of Clinical, Toxicological and Bromatological Analyses. Ribeirão Preto, SP, BrazilAutologous hematopoietic SCT (AHSCT) has been investigated in the past as a therapeutic alternative for multiple sclerosis (MS). Despite advances in clinical management, knowledge about mechanisms involved with clinical remission post transplantation is still limited. Abnormal microRNA and gene expression patterns were described in MS and have been suggested as disease biomarkers and potential therapeutic targets. Here we assessed T- and B-cell reconstitution, microRNAs and immunoregulatory gene expression after AHSCT. Early immune reconstitution was mainly driven by peripheral homeostatic proliferation. AHSCT increased CD4(+)CD25(hi)FoxP3(+) regulatory T-cell counts and expression of CTLA-4 and GITR (glucocorticoid-induced TNFR) on CD4(+)CD25(hi) T cells. We found transient increase in exhausted PD-1(+) T cells and of suppressive CD8(+)CD28(-)CD57(+) T cells. At baseline, CD4(+) and CD8(+) T cells from MS patients presented upregulated miR-16, miR-155 and miR-142-3p and downregulated FOXP3, FOXO1, PDCD1 and IRF2BP2. After transplantation, the expression of FOXP3, FOXO1, PDCD1 and IRF2BP2 increased, reaching control levels at 2 years. Expression of miR-16, miR-155 and miR-142-3p decreased towards normal levels at 6 months post therapy, remaining downregulated until the end of follow-up. These data strongly suggest that AHSCT normalizes microRNA and gene expression, thereby improving the immunoregulatory network. These mechanisms may be important for disease control in the early periods after AHSCT.engNature Publishing GroupEsclerose múltiplaTransplantesTransplante de célulasMicroRNAsHumanosMultiple sclerosisTransplantationCell TransplantationMicroRNAsHumansAutologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25071/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALArruda LCM Zanette Autologous hematopoietic SCT normalizes ....pdfArruda LCM Zanette Autologous hematopoietic SCT normalizes 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dc.title.pt_BR.fl_str_mv Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients
title Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients
spellingShingle Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients
Arruda, Lucas Coelho Marlière
Esclerose múltipla
Transplantes
Transplante de células
MicroRNAs
Humanos
Multiple sclerosis
Transplantation
Cell Transplantation
MicroRNAs
Humans
title_short Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients
title_full Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients
title_fullStr Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients
title_full_unstemmed Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients
title_sort Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients
author Arruda, Lucas Coelho Marlière
author_facet Arruda, Lucas Coelho Marlière
Lorenzi, Julio Cesar Cetrulo
Sousa, A P A
Zanette, Dalila Lucíola
Palma, Patricia Vianna Bonini
Panepucci, Rodrigo Alexander
Souza, Doralina Guimarães Brum
Barreira, Amilton Antunes
Covas, Dimas Tadeu
Simões, Belinda Pinto
Silva Junior, Wilson Araújo da
Oliveira, Maria Carolina
Malmegrim, Kelen Cristina Ribeiro
author_role author
author2 Lorenzi, Julio Cesar Cetrulo
Sousa, A P A
Zanette, Dalila Lucíola
Palma, Patricia Vianna Bonini
Panepucci, Rodrigo Alexander
Souza, Doralina Guimarães Brum
Barreira, Amilton Antunes
Covas, Dimas Tadeu
Simões, Belinda Pinto
Silva Junior, Wilson Araújo da
Oliveira, Maria Carolina
Malmegrim, Kelen Cristina Ribeiro
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Arruda, Lucas Coelho Marlière
Lorenzi, Julio Cesar Cetrulo
Sousa, A P A
Zanette, Dalila Lucíola
Palma, Patricia Vianna Bonini
Panepucci, Rodrigo Alexander
Souza, Doralina Guimarães Brum
Barreira, Amilton Antunes
Covas, Dimas Tadeu
Simões, Belinda Pinto
Silva Junior, Wilson Araújo da
Oliveira, Maria Carolina
Malmegrim, Kelen Cristina Ribeiro
dc.subject.other.pt_BR.fl_str_mv Esclerose múltipla
Transplantes
Transplante de células
MicroRNAs
Humanos
topic Esclerose múltipla
Transplantes
Transplante de células
MicroRNAs
Humanos
Multiple sclerosis
Transplantation
Cell Transplantation
MicroRNAs
Humans
dc.subject.en.pt_BR.fl_str_mv Multiple sclerosis
Transplantation
Cell Transplantation
MicroRNAs
Humans
description ZANETTE, Dalila Lucíola. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2018-03-06T15:34:01Z
dc.date.available.fl_str_mv 2018-03-06T15:34:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARRUDA, L. C. M. et al. Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients. Bone Marrow Transplantation, v. 50, p. 380–389, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25071
dc.identifier.issn.pt_BR.fl_str_mv 0268-3369
dc.identifier.doi.none.fl_str_mv 10.1038/bmt.2014.277
identifier_str_mv ARRUDA, L. C. M. et al. Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients. Bone Marrow Transplantation, v. 50, p. 380–389, 2015.
0268-3369
10.1038/bmt.2014.277
url https://www.arca.fiocruz.br/handle/icict/25071
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Nature Publishing Group
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