Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism

Detalhes bibliográficos
Autor(a) principal: Carneiro, Valdirene Leão
Data de Publicação: 2018
Outros Autores: Bendicho, Maria Teresita, Santos, Rosalina Guedes, Casela, Marilda, Martins Netto, Eduardo, Mota, Scarlet Torres Moraes, Pina, Iza Cristina Araújo, Nascimento, Roberto Meyer, Freire, Songeli Menezes, Barbosa, Theolis Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28070
Resumo: Conselho Nacional de Desenvolvimento Científico e Tecnológico (INCT-DT/MCT/CNPq 573839/2008-5) and Fundação de Amparo à Pesquisa do Estado da Bahia (PET035/2013).
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spelling Carneiro, Valdirene LeãoBendicho, Maria TeresitaSantos, Rosalina GuedesCasela, MarildaMartins Netto, EduardoMota, Scarlet Torres MoraesPina, Iza Cristina AraújoNascimento, Roberto MeyerFreire, Songeli MenezesBarbosa, Theolis Costa2018-08-13T14:23:58Z2018-08-13T14:23:58Z2018CARNEIRO, V. L. et al. Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism. Brazilian Journal of Infectious Diseases, v. 22, n. 3, p. 202–207, 2018.1413-8670https://www.arca.fiocruz.br/handle/icict/2807010.1016/j.bjid.2018.04.004Conselho Nacional de Desenvolvimento Científico e Tecnológico (INCT-DT/MCT/CNPq 573839/2008-5) and Fundação de Amparo à Pesquisa do Estado da Bahia (PET035/2013).Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Fundação José Silveira. Instituto Brasileiro para a Investigação da Tuberculose. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilLatent tuberculosis infection diagnosis based on the release of interferon-gamma in cultures of peripheral blood cells stimulated with Mycobacterium tuberculosis antigens has replaced the tuberculin skin test in many countries with low tuberculosis prevalence. The IFN-γ production can be influenced by genetic polymorphisms, of which the IFNG+874 (rs62559044) locus is the most studied. We investigated the possible influence of the IFNG+874 A/T polymorphism on interferon-gamma test performance. Methods: Patients diagnosed with pulmonary tuberculosis (75), volunteers with positivetuberculin skin test (70) and healthy volunteers with negative tuberculin skin test and no his-tory of contact with tuberculosis (57) were evaluated regarding the IFNG + 874 genotype andthe IFN- levels in whole blood cultures performed using an interferon-gamma commercialkit (QuantiFERON-TB®Gold In-Tube).Results: IFN- production was not influenced by the IFNG + 874 genotype, regardless of anti-gen or mitogen-based stimulation, which suggests that other genes may influence IFN- production in response to mycobacteria. The IFNG + 874 polymorphism was found to exertno influence over QFT-IT test sensitivity in our study.engElsevierInfecção por tuberculoseVariação genéticaSensitivityaTuberculosis infectionGenetic variationSensitivityaInterferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28070/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarneiro VL Interferon-gamma release assay ....pdfCarneiro VL Interferon-gamma release assay ....pdfapplication/pdf865425https://www.arca.fiocruz.br/bitstream/icict/28070/2/Carneiro%20VL%20Interferon-gamma%20release%20assay%20....pdf49fe950c24d031c54cbc006fce65c921MD52TEXTCarneiro VL 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dc.title.pt_BR.fl_str_mv Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism
title Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism
spellingShingle Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism
Carneiro, Valdirene Leão
Infecção por tuberculose
Variação genética
Sensitivitya
Tuberculosis infection
Genetic variation
Sensitivitya
title_short Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism
title_full Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism
title_fullStr Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism
title_full_unstemmed Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism
title_sort Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism
author Carneiro, Valdirene Leão
author_facet Carneiro, Valdirene Leão
Bendicho, Maria Teresita
Santos, Rosalina Guedes
Casela, Marilda
Martins Netto, Eduardo
Mota, Scarlet Torres Moraes
Pina, Iza Cristina Araújo
Nascimento, Roberto Meyer
Freire, Songeli Menezes
Barbosa, Theolis Costa
author_role author
author2 Bendicho, Maria Teresita
Santos, Rosalina Guedes
Casela, Marilda
Martins Netto, Eduardo
Mota, Scarlet Torres Moraes
Pina, Iza Cristina Araújo
Nascimento, Roberto Meyer
Freire, Songeli Menezes
Barbosa, Theolis Costa
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carneiro, Valdirene Leão
Bendicho, Maria Teresita
Santos, Rosalina Guedes
Casela, Marilda
Martins Netto, Eduardo
Mota, Scarlet Torres Moraes
Pina, Iza Cristina Araújo
Nascimento, Roberto Meyer
Freire, Songeli Menezes
Barbosa, Theolis Costa
dc.subject.other.pt_BR.fl_str_mv Infecção por tuberculose
Variação genética
Sensitivitya
topic Infecção por tuberculose
Variação genética
Sensitivitya
Tuberculosis infection
Genetic variation
Sensitivitya
dc.subject.en.pt_BR.fl_str_mv Tuberculosis infection
Genetic variation
Sensitivitya
description Conselho Nacional de Desenvolvimento Científico e Tecnológico (INCT-DT/MCT/CNPq 573839/2008-5) and Fundação de Amparo à Pesquisa do Estado da Bahia (PET035/2013).
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-08-13T14:23:58Z
dc.date.available.fl_str_mv 2018-08-13T14:23:58Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARNEIRO, V. L. et al. Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism. Brazilian Journal of Infectious Diseases, v. 22, n. 3, p. 202–207, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28070
dc.identifier.issn.pt_BR.fl_str_mv 1413-8670
dc.identifier.doi.none.fl_str_mv 10.1016/j.bjid.2018.04.004
identifier_str_mv CARNEIRO, V. L. et al. Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism. Brazilian Journal of Infectious Diseases, v. 22, n. 3, p. 202–207, 2018.
1413-8670
10.1016/j.bjid.2018.04.004
url https://www.arca.fiocruz.br/handle/icict/28070
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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