Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates

Detalhes bibliográficos
Autor(a) principal: Gama, Bianca Ervatti
Data de Publicação: 2009
Outros Autores: Oliveira, Natália Ketrin Almeida de, Souza, José Maria de, Daniel-Ribeiro, Cláudio Tadeu, Cruz, Maria de Fátima Ferreira da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28309
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
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spelling Gama, Bianca ErvattiOliveira, Natália Ketrin Almeida deSouza, José Maria deDaniel-Ribeiro, Cláudio TadeuCruz, Maria de Fátima Ferreira da2018-08-23T12:14:11Z2018-08-23T12:14:11Z2009GAMA, Bianca Ervatti; et al. Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates. Mem Inst Oswaldo Cruz, v.104, n.7, p.1009-1011, Nov. 2009.0074-0276https://www.arca.fiocruz.br/handle/icict/283091678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzPlasmodium vivaxMaláriaquimiorresistênciaPlasmodium vivaxmalariachemoresistancepvmdr1pvdhfrCharacterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolatesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.Instituto Evandro Chagas. Secretaria de Vigilância em Saúde. Ensaios Clínicos Ambulatoriais e Laboratoriais de Malária. Belém, PA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.Plasmodium vivax control is now being hampered by drug resistance. Orthologous Plasmodium falciparum genes linked to chloroquine or sulfadoxine-pyrimethamine chemoresistance have been identified in P. vivax parasites, but few studies have been performed. The goal of the present work is to characterise pvmdr1 and pvdhfr genes in parasite isolates from a Brazilian endemic area where no molecular investigation had been previously conducted. The pvmdr1 analysis revealed the existence of single (85.7%) and double (14.3%) mutant haplotypes, while the pvdhfr examination showed the presence of double (57.2%) and triple (42.8%) mutant haplotypes. The implications of these findings are discussed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28309/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALnataliaK_oliveira_etal_IOC_2009.pdfnataliaK_oliveira_etal_IOC_2009.pdfapplication/pdf371828https://www.arca.fiocruz.br/bitstream/icict/28309/2/nataliaK_oliveira_etal_IOC_2009.pdf6a8d03af0404e680f5018b975b9c8258MD52TEXTnataliaK_oliveira_etal_IOC_2009.pdf.txtnataliaK_oliveira_etal_IOC_2009.pdf.txtExtracted texttext/plain18515https://www.arca.fiocruz.br/bitstream/icict/28309/3/nataliaK_oliveira_etal_IOC_2009.pdf.txt36d89cd00e52b53e1751939644bd23e2MD53icict/283092018-08-24 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dc.title.pt_BR.fl_str_mv Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates
title Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates
spellingShingle Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates
Gama, Bianca Ervatti
Plasmodium vivax
Malária
quimiorresistência
Plasmodium vivax
malaria
chemoresistance
pvmdr1
pvdhfr
title_short Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates
title_full Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates
title_fullStr Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates
title_full_unstemmed Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates
title_sort Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates
author Gama, Bianca Ervatti
author_facet Gama, Bianca Ervatti
Oliveira, Natália Ketrin Almeida de
Souza, José Maria de
Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
author_role author
author2 Oliveira, Natália Ketrin Almeida de
Souza, José Maria de
Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gama, Bianca Ervatti
Oliveira, Natália Ketrin Almeida de
Souza, José Maria de
Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
dc.subject.other.pt_BR.fl_str_mv Plasmodium vivax
Malária
quimiorresistência
topic Plasmodium vivax
Malária
quimiorresistência
Plasmodium vivax
malaria
chemoresistance
pvmdr1
pvdhfr
dc.subject.en.pt_BR.fl_str_mv Plasmodium vivax
malaria
chemoresistance
pvmdr1
pvdhfr
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2018-08-23T12:14:11Z
dc.date.available.fl_str_mv 2018-08-23T12:14:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GAMA, Bianca Ervatti; et al. Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates. Mem Inst Oswaldo Cruz, v.104, n.7, p.1009-1011, Nov. 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28309
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv GAMA, Bianca Ervatti; et al. Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates. Mem Inst Oswaldo Cruz, v.104, n.7, p.1009-1011, Nov. 2009.
0074-0276
1678-8060
url https://www.arca.fiocruz.br/handle/icict/28309
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/28309/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/28309/2/nataliaK_oliveira_etal_IOC_2009.pdf
https://www.arca.fiocruz.br/bitstream/icict/28309/3/nataliaK_oliveira_etal_IOC_2009.pdf.txt
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